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Article: Is histological diagnosis of primary liver carcinomas with fibrous stroma reproducible among experts?

TitleIs histological diagnosis of primary liver carcinomas with fibrous stroma reproducible among experts?
Authors
Issue Date2009
PublisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/
Citation
Journal Of Clinical Pathology, 2009, v. 62 n. 6, p. 519-524 How to Cite?
AbstractAims: In the era of targeted therapeutics, histological typing of hepatobiliary carcinomas has major clinical implications. Little is known about the reproducibility of the pathological diagnosis of primary liver carcinomas. Therefore, this study aimed to evaluate the worldwide variation in the pathological expert diagnoses of primary liver carcinomas with fibrous stroma in patients who did not have cirrhosis. Methods: A single set of slides was selected from 25 tumours, and this set was reviewed independently by 12 pathologists who have worldwide expertise in liver tumours. Reproducibility of the diagnoses was evaluated by Light's κ, and diagnoses were clustered by multidimensional scaling. Immunohistochemistry was performed after histological review. Results: The interobserver reproducibility for diagnosis of hepatocellular carcinoma subtypes and cholangiocarcinomas was poor (κ 0.23-0.52), even when the experts considered that the diagnosis required no additional stains or clinical information. Interestingly, multidimensional scaling revealed three main clusters of tumours: hepatocellular carcinoma with no other specifications (n = 13), fibrolamellar hepatocellular carcinoma (n = 3) and cholangiocarcinoma (n = 9). Using immunohistochemistry, these histological clusters correlated with expression of anti-hepatocyte and anti-cytokeratin 19 (p<0.001). Conclusions: The results demonstrate the poor reproducibility among experts of the pathological diagnosis of primary liver carcinomas with fibrous stroma in patients who did not have cirrhosis, and highlight that the systematic use of immunohistochemistry may improve the diagnostic accuracy.
Persistent Identifierhttp://hdl.handle.net/10722/148604
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260
ISI Accession Number ID
Funding AgencyGrant Number
AREP (Association pour la Recherche et l'Enseignement en Pathologie)
Funding Information:

This work was supported by grants from AREP (Association pour la Recherche et l'Enseignement en Pathologie).

References

 

DC FieldValueLanguage
dc.contributor.authorMalouf, Gen_US
dc.contributor.authorFalissard, Ben_US
dc.contributor.authorAzoulay, Den_US
dc.contributor.authorCallea, Fen_US
dc.contributor.authorFerrell, LDen_US
dc.contributor.authorGoodman, ZDen_US
dc.contributor.authorHayashi, Yen_US
dc.contributor.authorHsu, HCen_US
dc.contributor.authorHubscher, SGen_US
dc.contributor.authorKojiro, Men_US
dc.contributor.authorNg, IOen_US
dc.contributor.authorPaterson, ACen_US
dc.contributor.authorReynes, Men_US
dc.contributor.authorZafrani, ESen_US
dc.contributor.authorEmile, JFen_US
dc.date.accessioned2012-05-29T06:14:03Z-
dc.date.available2012-05-29T06:14:03Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Clinical Pathology, 2009, v. 62 n. 6, p. 519-524en_US
dc.identifier.issn0021-9746en_US
dc.identifier.urihttp://hdl.handle.net/10722/148604-
dc.description.abstractAims: In the era of targeted therapeutics, histological typing of hepatobiliary carcinomas has major clinical implications. Little is known about the reproducibility of the pathological diagnosis of primary liver carcinomas. Therefore, this study aimed to evaluate the worldwide variation in the pathological expert diagnoses of primary liver carcinomas with fibrous stroma in patients who did not have cirrhosis. Methods: A single set of slides was selected from 25 tumours, and this set was reviewed independently by 12 pathologists who have worldwide expertise in liver tumours. Reproducibility of the diagnoses was evaluated by Light's κ, and diagnoses were clustered by multidimensional scaling. Immunohistochemistry was performed after histological review. Results: The interobserver reproducibility for diagnosis of hepatocellular carcinoma subtypes and cholangiocarcinomas was poor (κ 0.23-0.52), even when the experts considered that the diagnosis required no additional stains or clinical information. Interestingly, multidimensional scaling revealed three main clusters of tumours: hepatocellular carcinoma with no other specifications (n = 13), fibrolamellar hepatocellular carcinoma (n = 3) and cholangiocarcinoma (n = 9). Using immunohistochemistry, these histological clusters correlated with expression of anti-hepatocyte and anti-cytokeratin 19 (p<0.001). Conclusions: The results demonstrate the poor reproducibility among experts of the pathological diagnosis of primary liver carcinomas with fibrous stroma in patients who did not have cirrhosis, and highlight that the systematic use of immunohistochemistry may improve the diagnostic accuracy.en_US
dc.languageengen_US
dc.publisherB M J Publishing Group. The Journal's web site is located at http://jcp.bmjjournals.com/en_US
dc.relation.ispartofJournal of Clinical Pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies - Analysisen_US
dc.subject.meshCarcinoembryonic Antigen - Immunologyen_US
dc.subject.meshCarcinoma, Hepatocellular - Chemistry - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshCholangiocarcinoma - Chemistry - Pathologyen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatocytes - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshKeratin-19 - Immunologyen_US
dc.subject.meshKeratin-7 - Immunologyen_US
dc.subject.meshKeratins - Analysisen_US
dc.subject.meshLiver Neoplasms - Chemistry - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMedical Oncology - Standardsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshTumor Markers, Biological - Analysisen_US
dc.subject.meshYoung Adulten_US
dc.titleIs histological diagnosis of primary liver carcinomas with fibrous stroma reproducible among experts?en_US
dc.typeArticleen_US
dc.identifier.emailNg, IO:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IO=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/jcp.2008.062620en_US
dc.identifier.pmid19155239-
dc.identifier.scopuseid_2-s2.0-67649199417en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649199417&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume62en_US
dc.identifier.issue6en_US
dc.identifier.spage519en_US
dc.identifier.epage524en_US
dc.identifier.isiWOS:000266432900005-
dc.publisher.placeUnited Kingdomen_US

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