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Article: Role of leptin in immunity.

TitleRole of leptin in immunity.
Authors
Issue Date2007
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular & Molecular Immunology, 2007, v. 4 n. 1, p. 1-13 How to Cite?
AbstractLeptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis.
Persistent Identifierhttp://hdl.handle.net/10722/148510
ISSN
2015 Impact Factor: 5.193
2015 SCImago Journal Rankings: 1.898
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, QLen_US
dc.contributor.authorLu, Len_US
dc.date.accessioned2012-05-29T06:13:23Z-
dc.date.available2012-05-29T06:13:23Z-
dc.date.issued2007en_US
dc.identifier.citationCellular & Molecular Immunology, 2007, v. 4 n. 1, p. 1-13en_US
dc.identifier.issn1672-7681en_US
dc.identifier.urihttp://hdl.handle.net/10722/148510-
dc.description.abstractLeptin, a protein hormone produced by the adipocytes, has long been recognized to regulate metabolism, neuroendorine and other physiological functions. Early findings of increased leptin production during infection and inflammation and dysregulated immune response in leptin signaling-deficient mice provide strong evidence for the involvement of leptin in the immune responses. Recent data have established the regulatory function for leptin in immunity similar to the function of a pro-inflammatory cytokine, while gene-targeting studies also demonstrated an essential role of leptin in regulating hematopoiesis and lymphopoiesis. Moreover, there has been increasing evidence that leptin is involved in the pathogenesis of various autoimmune diseases. This review discusses recent advances in understanding the role of leptin in immunity and leptin-signaling pathways involved in modulating immune homeostasis and autoimmune pathogenesis.en_US
dc.languageengen_US
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_US
dc.relation.ispartofCellular & molecular immunologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAutoimmune Diseases - Immunologyen_US
dc.subject.meshHematopoiesis - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunityen_US
dc.subject.meshLeptin - Genetics - Metabolism - Physiologyen_US
dc.subject.meshMiceen_US
dc.subject.meshSignal Transductionen_US
dc.titleRole of leptin in immunity.en_US
dc.typeArticleen_US
dc.identifier.emailLam, QL:qlam@pathology.hku.hken_US
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_US
dc.identifier.authorityLam, QL=rp00312en_US
dc.identifier.authorityLu, L=rp00477en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17349207-
dc.identifier.scopuseid_2-s2.0-34249697436en_US
dc.identifier.hkuros132290-
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.spage1en_US
dc.identifier.epage13en_US
dc.identifier.isiWOS:000249671500001-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridLam, QL=8722491000-
dc.identifier.scopusauthoridLu, L=7403963552-

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