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Article: Expression of ΔNp73 and TAp73α independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma

TitleExpression of ΔNp73 and TAp73α independently associated with radiosensitivities and prognoses in cervical squamous cell carcinoma
Authors
Issue Date2006
Citation
Clinical Cancer Research, 2006, v. 12 n. 13, p. 3922-3927 How to Cite?
AbstractPurpose: The p73 gene produces different protein isoforms using alternative promoters and splicing, which have different biological characteristics. This study was to investigate the expression patterns of two distinct p73 isoforms (σNp73 and TAp73Δ) in cervical squamous cell carcinomas (SCC) and the relationship between their expressions and prognostic significance in cervical SCC patients. Experimental Design: We investigated the protein expressions of ΔNp73 and TAp73α in 117 cervical SCC and 113 normal cervical tissues using immunohistochemistry. The expression levels were analyzed with clinical variables and patients' survival. Results: ΔNp73 and TAp73α were significantly overexpressed in cervical SCC compared with those in normal cervical epithelium (P < 0.001). However, their expressions were inversely correlated (P < 0.001, R = -0.368) and associated with differential tumor radiosensitivity. Overexpression of ΔNP73 was significantly found in SCC resistant to irradiation (P < 0.001), whereas increase of TAp73α expression was observed in the majority of SCC sensitive to irradiation (P < 0.001). Multivariate and survival analyses indicated that the expressions of ΔNp73 and TAp73α were independently associated with prognosis: ΔNp73 was associated with recurrence of the disease [P = 0.001; odds ratio (OR), 4.857] and an adverse outcome (P = 0.012; OR, 4.676), whereas TAp73α predicted a better survival of cervical SCC patients (P = 0.018; OR, 0.065). Conclusions: The p73 gene might be an important determinant of cellular response to irradiation. The expressions of the two main isoforms (ΔNp73 and TAp73α) might be potential markers for predicting the prognosis and sensitivity to radiotherapy in patients with cervical SCC. © 2006 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/148471
ISSN
2015 Impact Factor: 8.738
2015 SCImago Journal Rankings: 5.314
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiu, SSen_HK
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLiao, XYen_HK
dc.contributor.authorLeung, TWen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2012-05-29T06:13:09Z-
dc.date.available2012-05-29T06:13:09Z-
dc.date.issued2006en_HK
dc.identifier.citationClinical Cancer Research, 2006, v. 12 n. 13, p. 3922-3927en_HK
dc.identifier.issn1078-0432en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148471-
dc.description.abstractPurpose: The p73 gene produces different protein isoforms using alternative promoters and splicing, which have different biological characteristics. This study was to investigate the expression patterns of two distinct p73 isoforms (σNp73 and TAp73Δ) in cervical squamous cell carcinomas (SCC) and the relationship between their expressions and prognostic significance in cervical SCC patients. Experimental Design: We investigated the protein expressions of ΔNp73 and TAp73α in 117 cervical SCC and 113 normal cervical tissues using immunohistochemistry. The expression levels were analyzed with clinical variables and patients' survival. Results: ΔNp73 and TAp73α were significantly overexpressed in cervical SCC compared with those in normal cervical epithelium (P < 0.001). However, their expressions were inversely correlated (P < 0.001, R = -0.368) and associated with differential tumor radiosensitivity. Overexpression of ΔNP73 was significantly found in SCC resistant to irradiation (P < 0.001), whereas increase of TAp73α expression was observed in the majority of SCC sensitive to irradiation (P < 0.001). Multivariate and survival analyses indicated that the expressions of ΔNp73 and TAp73α were independently associated with prognosis: ΔNp73 was associated with recurrence of the disease [P = 0.001; odds ratio (OR), 4.857] and an adverse outcome (P = 0.012; OR, 4.676), whereas TAp73α predicted a better survival of cervical SCC patients (P = 0.018; OR, 0.065). Conclusions: The p73 gene might be an important determinant of cellular response to irradiation. The expressions of the two main isoforms (ΔNp73 and TAp73α) might be potential markers for predicting the prognosis and sensitivity to radiotherapy in patients with cervical SCC. © 2006 American Association for Cancer Research.en_HK
dc.languageengen_US
dc.relation.ispartofClinical Cancer Researchen_HK
dc.titleExpression of ΔNp73 and TAp73α independently associated with radiosensitivities and prognoses in cervical squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailLiu, SS: stephasl@hku.hken_HK
dc.identifier.emailChan, KYK: kelvinc@pathology.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, SS=rp00372en_HK
dc.identifier.authorityChan, KYK=rp00453en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1158/1078-0432.CCR-05-2573en_HK
dc.identifier.scopuseid_2-s2.0-33746104471en_HK
dc.identifier.hkuros116921en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33746104471&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue13en_HK
dc.identifier.spage3922en_HK
dc.identifier.epage3927en_HK
dc.identifier.eissn1557-3265-
dc.identifier.isiWOS:000238930500010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiu, SS=37102450400en_HK
dc.identifier.scopusauthoridChan, KYK=7406034195en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLiao, XY=7202134156en_HK
dc.identifier.scopusauthoridLeung, TW=36823439400en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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