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Article: Novel function of TNF cytokines in regulating bone marrow B cell survival.

TitleNovel function of TNF cytokines in regulating bone marrow B cell survival.
Authors
Issue Date2004
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular & Molecular Immunology., 2004, v. 1 n. 6, p. 447-453 How to Cite?
AbstractTwo newly identified tumor necrosis factor (TNF) family cytokines, B cell activation factor from the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), have recently been shown to enhance the maturation and survival of peripheral B cells. However, whether BAFF and APRIL are expressed in the bone marrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear. In the present study, we have detected the abundant expression of BAFF and APRIL transcripts in BM non-lymphoid cells. Low levels of BAFF and APRIL mRNA are also found in developing B cells. Furthermore, we have determined the expression patterns of BAFF receptors during B lymphopoiesis. In cultures, both recombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF can suppress apoptosis of immature B cells. These findings suggest that BAFF and APRIL, in addition to their well established role in regulating peripheral B cell growth, can modulate the survival of developing B cells in the BM.
Persistent Identifierhttp://hdl.handle.net/10722/148458
ISSN
2015 Impact Factor: 5.193
2015 SCImago Journal Rankings: 1.898
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Men_HK
dc.contributor.authorKo, KHen_HK
dc.contributor.authorLam, QLen_HK
dc.contributor.authorLo, CKen_HK
dc.contributor.authorXu, DJen_HK
dc.contributor.authorShen, Len_HK
dc.contributor.authorZheng, Ben_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorLu, Len_HK
dc.date.accessioned2012-05-29T06:13:06Z-
dc.date.available2012-05-29T06:13:06Z-
dc.date.issued2004en_HK
dc.identifier.citationCellular & Molecular Immunology., 2004, v. 1 n. 6, p. 447-453en_HK
dc.identifier.issn1672-7681en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148458-
dc.description.abstractTwo newly identified tumor necrosis factor (TNF) family cytokines, B cell activation factor from the TNF family (BAFF) and a proliferation-inducing ligand (APRIL), have recently been shown to enhance the maturation and survival of peripheral B cells. However, whether BAFF and APRIL are expressed in the bone marrow (BM) microenvironment and if these two cytokines modulate early B cell development remain unclear. In the present study, we have detected the abundant expression of BAFF and APRIL transcripts in BM non-lymphoid cells. Low levels of BAFF and APRIL mRNA are also found in developing B cells. Furthermore, we have determined the expression patterns of BAFF receptors during B lymphopoiesis. In cultures, both recombinant BAFF and APRIL significantly promote the survival of precursor B cells whereas only BAFF can suppress apoptosis of immature B cells. These findings suggest that BAFF and APRIL, in addition to their well established role in regulating peripheral B cell growth, can modulate the survival of developing B cells in the BM.en_HK
dc.languageengen_US
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_HK
dc.relation.ispartofCellular & molecular immunology.en_HK
dc.subject.meshAnimalsen_US
dc.subject.meshB-Cell Activating Factoren_US
dc.subject.meshB-Cell Activation Factor Receptoren_US
dc.subject.meshB-Lymphocytes - Cytology - Immunologyen_US
dc.subject.meshBone Marrow Cells - Cytology - Immunologyen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Survivalen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteins - Genetics - Immunology - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshReceptors, Tumor Necrosis Factor - Genetics - Immunologyen_US
dc.subject.meshTranscription, Genetic - Geneticsen_US
dc.subject.meshTumor Necrosis Factor Ligand Superfamily Member 13en_US
dc.subject.meshTumor Necrosis Factor-Alpha - Genetics - Immunology - Metabolismen_US
dc.titleNovel function of TNF cytokines in regulating bone marrow B cell survival.en_HK
dc.typeArticleen_HK
dc.identifier.emailLam, QL:qlam@pathology.hku.hken_HK
dc.identifier.emailZheng, B:bzheng@hkucc.hku.hken_HK
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_HK
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_HK
dc.identifier.authorityLam, QL=rp00312en_HK
dc.identifier.authorityZheng, B=rp00353en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityLu, L=rp00477en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16293214-
dc.identifier.scopuseid_2-s2.0-33645268682en_HK
dc.identifier.hkuros97412-
dc.identifier.volume1en_HK
dc.identifier.issue6en_HK
dc.identifier.spage447en_HK
dc.identifier.epage453en_HK
dc.identifier.isiWOS:000208924500007-
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridZhang, M=36041252700en_HK
dc.identifier.scopusauthoridKo, KH=7202688627en_HK
dc.identifier.scopusauthoridLam, QL=8722491000en_HK
dc.identifier.scopusauthoridLo, CK=24825171000en_HK
dc.identifier.scopusauthoridXu, DJ=36792598300en_HK
dc.identifier.scopusauthoridShen, L=7401704659en_HK
dc.identifier.scopusauthoridZheng, B=7201780588en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridLu, L=7403963552en_HK

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