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Article: The pre-B cell receptor and its function during B cell development.

TitleThe pre-B cell receptor and its function during B cell development.
Authors
Issue Date2004
PublisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.html
Citation
Cellular & Molecular Immunology., 2004, v. 1 n. 2, p. 89-94 How to Cite?
AbstractThe process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and J segments of the Ig H and L chain gene loci. During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage. The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer Ig alpha/Ig beta. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cell proliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the Ig L chain genes. Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia.
Persistent Identifierhttp://hdl.handle.net/10722/148453
ISSN
2015 Impact Factor: 5.193
2015 SCImago Journal Rankings: 1.898
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Men_US
dc.contributor.authorSrivastava, Gen_US
dc.contributor.authorLu, Len_US
dc.date.accessioned2012-05-29T06:13:04Z-
dc.date.available2012-05-29T06:13:04Z-
dc.date.issued2004en_US
dc.identifier.citationCellular & Molecular Immunology., 2004, v. 1 n. 2, p. 89-94en_US
dc.identifier.issn1672-7681en_US
dc.identifier.urihttp://hdl.handle.net/10722/148453-
dc.description.abstractThe process of B cell development in the bone marrow occurs by the stepwise rearrangements of the V, D, and J segments of the Ig H and L chain gene loci. During early B cell genesis, productive Ig H chain gene rearrangement leads to assembly of the pre-B cell receptor (pre-BCR), which acts as an important checkpoint at the pro-B/preB transitional stage. The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer Ig alpha/Ig beta. Signaling through the pre-BCR regulates allelic exclusion at the Ig H locus, stimulates cell proliferation, and induces differentiation to small post-mitotic pre-B cells that further undergo the rearrangement of the Ig L chain genes. Recent advances in elucidating the key roles of pre-BCR in B cell development have provided a better understanding of normal B lymphopoiesis and its dysregulated state leading to B cell neoplasia.en_US
dc.languageengen_US
dc.publisherChinese Society of Immunology. The Journal's web site is located at http://www.nature.com/cmi/index.htmlen_US
dc.relation.ispartofCellular & molecular immunology.en_US
dc.subject.meshAnimalsen_US
dc.subject.meshB-Lymphocytes - Immunology - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Heavy Chains - Metabolismen_US
dc.subject.meshMembrane Glycoproteins - Immunologyen_US
dc.subject.meshMultiprotein Complexesen_US
dc.subject.meshPre-B Cell Receptorsen_US
dc.subject.meshReceptors, Antigen, B-Cellen_US
dc.subject.meshSignal Transduction - Physiologyen_US
dc.titleThe pre-B cell receptor and its function during B cell development.en_US
dc.typeArticleen_US
dc.identifier.emailSrivastava, G:gopesh@pathology.hku.hken_US
dc.identifier.emailLu, L:liweilu@hkucc.hku.hken_US
dc.identifier.authoritySrivastava, G=rp00365en_US
dc.identifier.authorityLu, L=rp00477en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16212894-
dc.identifier.scopuseid_2-s2.0-33644825803en_US
dc.identifier.hkuros87420-
dc.identifier.hkuros139352-
dc.identifier.volume1en_US
dc.identifier.issue2en_US
dc.identifier.spage89en_US
dc.identifier.epage94en_US
dc.identifier.isiWOS:000208922200002-
dc.publisher.placeChinaen_US

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