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Article: Subcutaneous panniculitislike T-cell lymphoma appearing as a breast mass: A difficult and challenging case appearing at an unusual site

TitleSubcutaneous panniculitislike T-cell lymphoma appearing as a breast mass: A difficult and challenging case appearing at an unusual site
Authors
Issue Date2005
PublisherAmerican Institute for Ultrasound in Medicine. The Journal's web site is located at http://www.aium.org/publications/jum/subIndv.asp
Citation
Journal Of Ultrasound In Medicine, 2005, v. 24 n. 10, p. 1453-1460 How to Cite?
AbstractSubcutaneous panniculitislike T-cell lymphoma (SPTCL) is a rare subtype of cutaneous lymphoma. It appears clinically with erythematous, subcutaneous infiltrates and recurrent papulonodules. It is rare in young patients, with only a few reported cases. We report the case of a 23-year-old healthy woman with an atypical appearance of SPTCL. She initially came to our institution with a 3-month history of a left breast mass. Biopsy showed scattered reactive macrophages, multinucleated giant cells, and mixed lymphoid infiltrates suggestive of acute panniculitis. Her condition improved clinically with conservative treatment. More than 3.5 years later, multiple painful, self-remitting crops of skin nodules developed over her extremities, associated with intermittent low-grade fever, night sweats, and weight loss. The diagnosis of SPTCL was finally made from a skin biopsy obtained from her forearm. Hemophagocytosis, a known, often fatal complication, was not evident. She received combination chemotherapy with fludarabine, mitoxantrone, and dexamethasone with good response. The initial breast biopsy specimens were reexamined. Deeper sections revealed the presence of some atypical lymphoid cells but with inadequate features for the diagnosis of SPTCL. However, the clinical improvement of her breast condition with combination chemotherapy is supportive of involvement of a lymphomatous process. We review her clinical appearance, radiologic findings, histologic features, treatment, and outcome. To the best of our knowledge, SPTCL appearing as a breast mass has not been reported previously, and this report stresses the importance of repeated biopsy when SPTCL is suspected. © 2005 by the American Institute of Ultrasound in Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/148429
ISSN
2015 Impact Factor: 1.544
2015 SCImago Journal Rankings: 0.645
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSy, ANLen_US
dc.contributor.authorLam, TPWen_US
dc.contributor.authorKhoo, USen_US
dc.date.accessioned2012-05-29T06:12:55Z-
dc.date.available2012-05-29T06:12:55Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Ultrasound In Medicine, 2005, v. 24 n. 10, p. 1453-1460en_US
dc.identifier.issn0278-4297en_US
dc.identifier.urihttp://hdl.handle.net/10722/148429-
dc.description.abstractSubcutaneous panniculitislike T-cell lymphoma (SPTCL) is a rare subtype of cutaneous lymphoma. It appears clinically with erythematous, subcutaneous infiltrates and recurrent papulonodules. It is rare in young patients, with only a few reported cases. We report the case of a 23-year-old healthy woman with an atypical appearance of SPTCL. She initially came to our institution with a 3-month history of a left breast mass. Biopsy showed scattered reactive macrophages, multinucleated giant cells, and mixed lymphoid infiltrates suggestive of acute panniculitis. Her condition improved clinically with conservative treatment. More than 3.5 years later, multiple painful, self-remitting crops of skin nodules developed over her extremities, associated with intermittent low-grade fever, night sweats, and weight loss. The diagnosis of SPTCL was finally made from a skin biopsy obtained from her forearm. Hemophagocytosis, a known, often fatal complication, was not evident. She received combination chemotherapy with fludarabine, mitoxantrone, and dexamethasone with good response. The initial breast biopsy specimens were reexamined. Deeper sections revealed the presence of some atypical lymphoid cells but with inadequate features for the diagnosis of SPTCL. However, the clinical improvement of her breast condition with combination chemotherapy is supportive of involvement of a lymphomatous process. We review her clinical appearance, radiologic findings, histologic features, treatment, and outcome. To the best of our knowledge, SPTCL appearing as a breast mass has not been reported previously, and this report stresses the importance of repeated biopsy when SPTCL is suspected. © 2005 by the American Institute of Ultrasound in Medicine.en_US
dc.languageengen_US
dc.publisherAmerican Institute for Ultrasound in Medicine. The Journal's web site is located at http://www.aium.org/publications/jum/subIndv.aspen_US
dc.relation.ispartofJournal of Ultrasound in Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsy, Fine-Needleen_US
dc.subject.meshBreast - Pathologyen_US
dc.subject.meshBreast Neoplasms - Pathology - Radiography - Ultrasonographyen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphoma, T-Cell, Cutaneous - Pathology - Radiography - Ultrasonographyen_US
dc.subject.meshMammographyen_US
dc.subject.meshPanniculitis - Pathology - Radiography - Ultrasonographyen_US
dc.subject.meshSkin Neoplasms - Pathology - Radiography - Ultrasonographyen_US
dc.subject.meshUltrasonography, Mammaryen_US
dc.titleSubcutaneous panniculitislike T-cell lymphoma appearing as a breast mass: A difficult and challenging case appearing at an unusual siteen_US
dc.typeArticleen_US
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_US
dc.identifier.authorityKhoo, US=rp00362en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid16179634en_US
dc.identifier.scopuseid_2-s2.0-25844504186en_US
dc.identifier.hkuros113124-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-25844504186&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue10en_US
dc.identifier.spage1453en_US
dc.identifier.epage1460en_US
dc.identifier.isiWOS:000232311900020-
dc.publisher.placeUnited Statesen_US

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