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Article: Is hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database.

TitleIs hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database.
Authors
KeywordsCarcinoma
Hepatectomy
Hepatocellular
Large
Multinodular
Issue Date2005
PublisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.org
Citation
Annals Of Surgical Oncology : The Official Journal Of The Society Of Surgical Oncology, 2005, v. 12 n. 5, p. 364-373 How to Cite?
AbstractBACKGROUND: The role of surgical resection in patients with large or multinodular hepatocellular carcinoma (HCC) remains unclear. This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database. METHODS: The perioperative and long-term outcomes of 404 patients with small HCC (<5 cm in diameter; group 1) were compared with those of 380 patients with large or multinodular HCC (group 2). The prognostic factors in the latter group were analyzed. RESULTS: The postoperative complication rate (27% vs. 23%; P = .16) and hospital mortality rate (2.4% vs. 2.7%; P = .82) were similar between groups. The overall survival rates were significantly higher in group 1 than group 2 (1 year, 88% vs. 74%; 3 years, 76% vs. 50%; 5 years, 58% vs. 39%; P < .001). Among patients in group 2, five independent prognostic factors were identified to be associated with a worse overall survival: namely, symptomatic disease, presence of cirrhosis, multinodular tumor, microvascular tumor invasion, and positive histological margin. CONCLUSIONS: Hepatic resection can be safely performed in patients with large or multinodular HCC, with an overall 5-year survival rate of 39%. Symptomatic disease, the presence of cirrhosis, a multinodular tumor, microvascular invasion, and a positive histological margin are independently associated with a less favorable survival outcome.
Persistent Identifierhttp://hdl.handle.net/10722/148420
ISSN
2015 Impact Factor: 3.655
2015 SCImago Journal Rankings: 1.902
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNg, KKen_HK
dc.contributor.authorVauthey, JNen_HK
dc.contributor.authorPawlik, TMen_HK
dc.contributor.authorLauwers, GYen_HK
dc.contributor.authorRegimbeau, JMen_HK
dc.contributor.authorBelghiti, Jen_HK
dc.contributor.authorIkai, Ien_HK
dc.contributor.authorYamaoka, Yen_HK
dc.contributor.authorCurley, SAen_HK
dc.contributor.authorNagorney, DMen_HK
dc.contributor.authorNg, IOen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorPoon, RTen_HK
dc.date.accessioned2012-05-29T06:12:52Z-
dc.date.available2012-05-29T06:12:52Z-
dc.date.issued2005en_HK
dc.identifier.citationAnnals Of Surgical Oncology : The Official Journal Of The Society Of Surgical Oncology, 2005, v. 12 n. 5, p. 364-373en_HK
dc.identifier.issn1068-9265en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148420-
dc.description.abstractBACKGROUND: The role of surgical resection in patients with large or multinodular hepatocellular carcinoma (HCC) remains unclear. This study evaluated the long-term outcome of patients with hepatic resection for large (>5 cm in diameter) or multinodular (more than three nodules) HCC by using a multi-institutional database. METHODS: The perioperative and long-term outcomes of 404 patients with small HCC (<5 cm in diameter; group 1) were compared with those of 380 patients with large or multinodular HCC (group 2). The prognostic factors in the latter group were analyzed. RESULTS: The postoperative complication rate (27% vs. 23%; P = .16) and hospital mortality rate (2.4% vs. 2.7%; P = .82) were similar between groups. The overall survival rates were significantly higher in group 1 than group 2 (1 year, 88% vs. 74%; 3 years, 76% vs. 50%; 5 years, 58% vs. 39%; P < .001). Among patients in group 2, five independent prognostic factors were identified to be associated with a worse overall survival: namely, symptomatic disease, presence of cirrhosis, multinodular tumor, microvascular tumor invasion, and positive histological margin. CONCLUSIONS: Hepatic resection can be safely performed in patients with large or multinodular HCC, with an overall 5-year survival rate of 39%. Symptomatic disease, the presence of cirrhosis, a multinodular tumor, microvascular invasion, and a positive histological margin are independently associated with a less favorable survival outcome.en_HK
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.annalssurgicaloncology.orgen_HK
dc.relation.ispartofAnnals of surgical oncology : the official journal of the Society of Surgical Oncologyen_HK
dc.subjectCarcinoma-
dc.subjectHepatectomy-
dc.subjectHepatocellular-
dc.subjectLarge-
dc.subjectMultinodular-
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular - Mortality - Pathology - Surgeryen_US
dc.subject.meshHepatectomyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Mortality - Pathology - Surgeryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNeoplasm Invasivenessen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Analysisen_US
dc.titleIs hepatic resection for large or multinodular hepatocellular carcinoma justified? Results from a multi-institutional database.en_HK
dc.typeArticleen_HK
dc.identifier.emailNg, IO: iolng@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.authorityNg, IO=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1245/ASO.2005.06.004-
dc.identifier.pmid15915370-
dc.identifier.scopuseid_2-s2.0-22844444687en_HK
dc.identifier.hkuros98172-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21144435718&selection=ref&src=s&origin=recordpage-
dc.identifier.volume12en_HK
dc.identifier.issue5en_HK
dc.identifier.spage364en_HK
dc.identifier.epage373en_HK
dc.identifier.isiWOS:000228874900006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, KK=35248894000en_HK
dc.identifier.scopusauthoridVauthey, JN=35270590000en_HK
dc.identifier.scopusauthoridPawlik, TM=7006249269en_HK
dc.identifier.scopusauthoridLauwers, GY=35391239300en_HK
dc.identifier.scopusauthoridRegimbeau, JM=7003436804en_HK
dc.identifier.scopusauthoridBelghiti, J=35403099400en_HK
dc.identifier.scopusauthoridIkai, I=7006764463en_HK
dc.identifier.scopusauthoridYamaoka, Y=7201994050en_HK
dc.identifier.scopusauthoridCurley, SA=7006597814en_HK
dc.identifier.scopusauthoridNagorney, DM=35400419300en_HK
dc.identifier.scopusauthoridNg, IO=7102753722en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK

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