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Article: CDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach

TitleCDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomach
Authors
Ko, SChu, KMLuk, JMCWong, BWYYuen, STLeung, SYWong, J
KeywordsCDX2
Gastric adenocarcinoma
Immunohistochemistry
Intestinal metaplasia
LI-cadherin
RT-PCR
Issue Date2005
PublisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130
Citation
Journal of Pathology, 2005, v. 205 n. 5, p. 615-622 How to Cite?
DOI: http://dx.doi.org/10.1002/path.1741
AbstractCDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon. Recent studies have demonstrated that CDX2 regulates LI-cadherin gene (CDH17) expression in colorectal cancer. The present study investigated the relationship of CDX2 and LI-cadherin expression in gastric cancer. One hundred and nine pairs of tumour and non-cancerous gastric mucosa were collected from gastrectomy specimens. Protein expression levels of CDX2 and LI-cadherin were determined by immunohistochemical staining. Semi-quantitative RT-PCR showed that the mRNAs of both CDX2 and CDH17 were highly expressed in tumour compared with non-cancerous mucosa. Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma. Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia. In conclusion, overexpression of CDH-17 is significantly associated with CDX2. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/148402
ISSN
0022-3417
2023 Impact Factor: 5.6
2023 SCImago Journal Rankings: 2.426
ISI Accession Number ID
WOS:000228197200010
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorKo, Sen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorLuk, JMCen_HK
dc.contributor.authorWong, BWYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2012-05-29T06:12:45Z-
dc.date.available2012-05-29T06:12:45Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal of Pathology, 2005, v. 205 n. 5, p. 615-622en_HK
dc.identifier.issn0022-3417en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148402-
dc.description.abstractCDX2 and liver-intestine (LI)-cadherin are intestine-specific markers and both are physiologically expressed in the small intestine and colon. Recent studies have demonstrated that CDX2 regulates LI-cadherin gene (CDH17) expression in colorectal cancer. The present study investigated the relationship of CDX2 and LI-cadherin expression in gastric cancer. One hundred and nine pairs of tumour and non-cancerous gastric mucosa were collected from gastrectomy specimens. Protein expression levels of CDX2 and LI-cadherin were determined by immunohistochemical staining. Semi-quantitative RT-PCR showed that the mRNAs of both CDX2 and CDH17 were highly expressed in tumour compared with non-cancerous mucosa. Overexpression of CDX2 was significantly associated with CDH17 in gastric adenocarcinoma. Furthermore, the expression of CDX2 and LI-cadherin proteins was strongly coupled in intestinal metaplasia. In conclusion, overexpression of CDH-17 is significantly associated with CDX2. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/1130en_HK
dc.relation.ispartofJournal of Pathologyen_HK
dc.rightsJournal of Pathology. Copyright © John Wiley & Sons Ltd.-
dc.subjectCDX2en_HK
dc.subjectGastric adenocarcinomaen_HK
dc.subjectImmunohistochemistryen_HK
dc.subjectIntestinal metaplasiaen_HK
dc.subjectLI-cadherinen_HK
dc.subjectRT-PCRen_HK
dc.subject.meshAdenocarcinoma - Metabolism - Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCadherins - Genetics - Metabolismen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHomeodomain Proteins - Genetics - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMaleen_US
dc.subject.meshMetaplasia - Metabolismen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Proteins - Genetics - Metabolismen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPrecancerous Conditions - Metabolismen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction - Methodsen_US
dc.subject.meshStomach - Pathologyen_US
dc.subject.meshStomach Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshTumor Markers, Biological - Genetics - Metabolismen_US
dc.subject.meshUp-Regulationen_US
dc.titleCDX2 co-localizes with liver-intestine cadherin in intestinal metaplasia and adenocarcinoma of the stomachen_HK
dc.typeArticleen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLuk, JMC: jmluk@hkucc.hku.hken_HK
dc.identifier.emailYuen, ST: styuen@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hk-
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLuk, JMC=rp00349en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/path.1741en_HK
dc.identifier.pmid15732140-
dc.identifier.scopuseid_2-s2.0-17144418415en_HK
dc.identifier.hkuros97604-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17144418415&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume205en_HK
dc.identifier.issue5en_HK
dc.identifier.spage615en_HK
dc.identifier.epage622en_HK
dc.identifier.isiWOS:000228197200010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKo, S=7403326231en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridLuk, JMC=7006777791en_HK
dc.identifier.scopusauthoridWong, BWY=8602085500en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.citeulike139054-
dc.customcontrol.immutablesml 130621-
dc.identifier.issnl0022-3417-

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