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Article: Hepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma

TitleHepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinoma
Authors
KeywordsHepatitis
Hepatocellular carcinoma
Resection
Issue Date2004
Citation
Journal Of Gastrointestinal Surgery, 2004, v. 8 n. 7, p. 794-805 How to Cite?
AbstractThe impact of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on survival rates after resection of hepatocellular carcinoma (HCC) is controversial. The objective of this study was to determine whether serologic evidence of HBV or HCV infection ("hepatitis serology") can predict underlying liver disease, tumor factors, and survival rates in patients with HCC. Using a multicenter international database, we identified 446 patients with complete HBV and HCV serology. One hundred twenty-six patients were negative for HBV and HCV, 163 patients had HBV infection only, 79 patients had HCV infection only, and 78 patients had coinfection with HBV and HCV. Patients with hepatitis were more likely to have tumors smaller than 5 cm and bilateral HCC involvement. Hepatitis status (negative vs. HBV vs. HCV vs. coinfection with HBV and HCV) did not predict tumor grade or the presence of multiple tumor nodules. Patients with HCV or coinfection with HBV and HCV exhibited a lower incidence of vascular invasion, but worse fibrosis than patients with negative serology or HBV. The median survival rate was 47.9 months. The presence of hepatitis did not significantly affect the survival rate, but hepatic fibrosis and vascular invasion predicted a decreased survival rate. The prognosis after resection of HCC is influenced by tumor factors and liver disease, but not by HBV or HCV infection. The treatment for HCC should be dictated by the extent of underlying liver disease rather than by hepatitis serology. © 2004 The Society for Surgery of the Alimentary Tract.
Persistent Identifierhttp://hdl.handle.net/10722/148401
ISSN
2015 Impact Factor: 2.807
2015 SCImago Journal Rankings: 1.640
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorPawlik, TMen_HK
dc.contributor.authorPoon, RTen_HK
dc.contributor.authorAbdalla, EKen_HK
dc.contributor.authorSarmiento, JMen_HK
dc.contributor.authorIkai, Ien_HK
dc.contributor.authorCurley, SAen_HK
dc.contributor.authorNagorney, DMen_HK
dc.contributor.authorBelghiti, Jen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorYamaoka, Yen_HK
dc.contributor.authorLauwers, GYen_HK
dc.contributor.authorVauthey, JNen_HK
dc.contributor.authorChoti, Men_HK
dc.contributor.authorKelly, Ken_HK
dc.date.accessioned2012-05-29T06:12:44Z-
dc.date.available2012-05-29T06:12:44Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Gastrointestinal Surgery, 2004, v. 8 n. 7, p. 794-805en_HK
dc.identifier.issn1091-255Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/148401-
dc.description.abstractThe impact of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on survival rates after resection of hepatocellular carcinoma (HCC) is controversial. The objective of this study was to determine whether serologic evidence of HBV or HCV infection ("hepatitis serology") can predict underlying liver disease, tumor factors, and survival rates in patients with HCC. Using a multicenter international database, we identified 446 patients with complete HBV and HCV serology. One hundred twenty-six patients were negative for HBV and HCV, 163 patients had HBV infection only, 79 patients had HCV infection only, and 78 patients had coinfection with HBV and HCV. Patients with hepatitis were more likely to have tumors smaller than 5 cm and bilateral HCC involvement. Hepatitis status (negative vs. HBV vs. HCV vs. coinfection with HBV and HCV) did not predict tumor grade or the presence of multiple tumor nodules. Patients with HCV or coinfection with HBV and HCV exhibited a lower incidence of vascular invasion, but worse fibrosis than patients with negative serology or HBV. The median survival rate was 47.9 months. The presence of hepatitis did not significantly affect the survival rate, but hepatic fibrosis and vascular invasion predicted a decreased survival rate. The prognosis after resection of HCC is influenced by tumor factors and liver disease, but not by HBV or HCV infection. The treatment for HCC should be dictated by the extent of underlying liver disease rather than by hepatitis serology. © 2004 The Society for Surgery of the Alimentary Tract.en_HK
dc.languageengen_US
dc.relation.ispartofJournal of Gastrointestinal Surgeryen_HK
dc.subjectHepatitisen_HK
dc.subjectHepatocellular carcinomaen_HK
dc.subjectResectionen_HK
dc.titleHepatitis serology predicts tumor and liver-disease characteristics but not prognosis after resection of hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailPoon, RT: poontp@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.authorityPoon, RT=rp00446en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.gassur.2004.06.013en_HK
dc.identifier.pmid15531232-
dc.identifier.scopuseid_2-s2.0-16644403674en_HK
dc.identifier.hkuros99723-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-16644403674&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue7en_HK
dc.identifier.spage794en_HK
dc.identifier.epage805en_HK
dc.identifier.isiWOS:000225633000007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridPawlik, TM=7006249269en_HK
dc.identifier.scopusauthoridPoon, RT=7103097223en_HK
dc.identifier.scopusauthoridAbdalla, EK=7006112354en_HK
dc.identifier.scopusauthoridSarmiento, JM=7005720205en_HK
dc.identifier.scopusauthoridIkai, I=7006764463en_HK
dc.identifier.scopusauthoridCurley, SA=7006597814en_HK
dc.identifier.scopusauthoridNagorney, DM=35400419300en_HK
dc.identifier.scopusauthoridBelghiti, J=35403099400en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridYamaoka, Y=7201994050en_HK
dc.identifier.scopusauthoridLauwers, GY=35391239300en_HK
dc.identifier.scopusauthoridVauthey, JN=35270590000en_HK
dc.identifier.scopusauthoridChoti, M=7005884714en_HK
dc.identifier.scopusauthoridKelly, K=7401769361en_HK

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