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Article: The expression of DNA mismatch repair genes and detection of DNA ploidy in young patients with colorectal carcinoma

TitleThe expression of DNA mismatch repair genes and detection of DNA ploidy in young patients with colorectal carcinoma
Authors
Issue Date2000
Citation
Zhonghua Bing Li Xue Za Zhi Chinese Journal Of Pathology, 2000, v. 29 n. 6, p. 412-415 How to Cite?
AbstractOBJECTIVE: To investigate the clinicopathologic characters and carcinogentic pathways of young (age < 36) colorectal carcinomas (CRCs) in Guangzhou, China. METHODS: Immunohistochemistry and flow cytometry methods were used to detect the expression of hMSH(2) and hMLH(1), status of DNA ploidy in 63 cases of young CRCs from Guangzhou, China, and analyze their correlations with patient's clinicopathological characters. RESULTS: Of the 63 young CRCs studied, forty-four (69.8%) tumors were non-mucinous carcinomas, thirty-nine (61.9%) patients were in Dukes' C or D stage. Of the 59 CRCs which were successfully detected by immunohistochemistry and flow cytometry, ten (16.9%) CRCs lost either hMSH(2) or hMLH(1) and showed DNA diploid or near-diploid, while twenty-six (44.1%) had aneuploid DNA content and all with the normal expression of hMSH(2) and hMLH(1). In addition, there existed a significant percentage (23/59, 39%) of young CRCs showing no loss of either of these two mismatch repair proteins and having a diploid or near diploid DNA content. CONCLUSION: The overall percentage of young CRCs in Guangzhou is significantly higher than those in Caucasian predominant countries and about seventy percent of young CRCs in Guangzhou are conventional carcinomas. 39% of young CRCs in Guangzhou showed no evidence of either chromosomal instability or microsatellite instability carcinogentic pathway, indicating that there must be at least a third pathway which triggers the CRCs in these special subgroups of young patients in Guangzhou, China.
Persistent Identifierhttp://hdl.handle.net/10722/148394
ISSN
2015 SCImago Journal Rankings: 0.136

 

DC FieldValueLanguage
dc.contributor.authorXie, Den_US
dc.contributor.authorLeung, Sen_US
dc.contributor.authorZeng, Wen_US
dc.contributor.authorZhang, Men_US
dc.contributor.authorChan, Aen_US
dc.contributor.authorYuen, Sen_US
dc.contributor.authorWen, Jen_US
dc.date.accessioned2012-05-29T06:12:42Z-
dc.date.available2012-05-29T06:12:42Z-
dc.date.issued2000en_US
dc.identifier.citationZhonghua Bing Li Xue Za Zhi Chinese Journal Of Pathology, 2000, v. 29 n. 6, p. 412-415en_US
dc.identifier.issn0529-5807en_US
dc.identifier.urihttp://hdl.handle.net/10722/148394-
dc.description.abstractOBJECTIVE: To investigate the clinicopathologic characters and carcinogentic pathways of young (age < 36) colorectal carcinomas (CRCs) in Guangzhou, China. METHODS: Immunohistochemistry and flow cytometry methods were used to detect the expression of hMSH(2) and hMLH(1), status of DNA ploidy in 63 cases of young CRCs from Guangzhou, China, and analyze their correlations with patient's clinicopathological characters. RESULTS: Of the 63 young CRCs studied, forty-four (69.8%) tumors were non-mucinous carcinomas, thirty-nine (61.9%) patients were in Dukes' C or D stage. Of the 59 CRCs which were successfully detected by immunohistochemistry and flow cytometry, ten (16.9%) CRCs lost either hMSH(2) or hMLH(1) and showed DNA diploid or near-diploid, while twenty-six (44.1%) had aneuploid DNA content and all with the normal expression of hMSH(2) and hMLH(1). In addition, there existed a significant percentage (23/59, 39%) of young CRCs showing no loss of either of these two mismatch repair proteins and having a diploid or near diploid DNA content. CONCLUSION: The overall percentage of young CRCs in Guangzhou is significantly higher than those in Caucasian predominant countries and about seventy percent of young CRCs in Guangzhou are conventional carcinomas. 39% of young CRCs in Guangzhou showed no evidence of either chromosomal instability or microsatellite instability carcinogentic pathway, indicating that there must be at least a third pathway which triggers the CRCs in these special subgroups of young patients in Guangzhou, China.en_US
dc.languageengen_US
dc.relation.ispartofZhonghua bing li xue za zhi Chinese journal of pathologyen_US
dc.subject.meshAdaptor Proteins, Signal Transducingen_US
dc.subject.meshAdenocarcinoma - Genetics - Metabolism - Pathologyen_US
dc.subject.meshAdenocarcinoma, Mucinous - Genetics - Metabolism - Pathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAneuploidyen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBase Pair Mismatchen_US
dc.subject.meshCarrier Proteinsen_US
dc.subject.meshChinaen_US
dc.subject.meshColonic Neoplasms - Genetics - Metabolism - Pathologyen_US
dc.subject.meshDna Repairen_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshDna-Binding Proteins - Metabolismen_US
dc.subject.meshDiploidyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMuts Homolog 2 Proteinen_US
dc.subject.meshNeoplasm Proteins - Metabolismen_US
dc.subject.meshNuclear Proteinsen_US
dc.subject.meshProto-Oncogene Proteins - Metabolismen_US
dc.subject.meshRectal Neoplasms - Genetics - Metabolism - Pathologyen_US
dc.subject.meshSpecies Specificityen_US
dc.titleThe expression of DNA mismatch repair genes and detection of DNA ploidy in young patients with colorectal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailLeung, S:suetyi@hkucc.hku.hken_US
dc.identifier.authorityLeung, S=rp00359en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11866941en_US
dc.identifier.scopuseid_2-s2.0-14744302152en_US
dc.identifier.volume29en_US
dc.identifier.issue6en_US
dc.identifier.spage412en_US
dc.identifier.epage415en_US

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