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Article: Liver transplantation in children: The experience of Queen Mary Hospital, Hong Kong
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TitleLiver transplantation in children: The experience of Queen Mary Hospital, Hong Kong
 
AuthorsSaing, H1
Fan, ST
Chan, KL
Wei, WI
Lo, CM
Mya, GH
Tsoi, NS
Yuen, KY
Ng, IOL
Lo, JWR
Chau, MT
Tsoi, WK
Chan, J
Wong, J
 
Keywordsbiliary atresia
Living-related liver transplantation
microvascular anastomosis
reduced-size liver transplantation
 
Issue Date1997
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
 
CitationJournal Of Pediatric Surgery, 1997, v. 32 n. 1, p. 80-83 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0022-3468(97)90100-7
 
AbstractSeven living-related liver transplants (LRLT) and two reduced-size liver transplants (RSLT) were performed on eight children who suffered from end- stage liver disease, having previously undergone one to three abdominal operations. Their ages at initial transplantation ranged from 8 months to 11 years (mean 35 months, median 12 months). Excluding the two older children aged 7 and 11 years, respectively, the rest of the children weighed 6 to 9.5 kg (mean 7.3 kg) at the time of the initial transplantation. Seven left lateral segments (S2 + 3) and two left lobes (S2 + 3 + 4) were used; of these the smallest graft had a graft-to-recipient body weight ratio of 0.9%. The volunteer living donors were four mothers, two fathers and one sister who were selected after medical and psychiatric evaluations, and their suitability was confirmed by hematological, biochemical, and radiological criteria. During a follow-up period of 3 to 30 months, all eight children are alive and well with normal liver function, one of them having undergone a retransplant LRLT because of hepatitis of undetermined etiology following a RSLT 1.5 years earlier. All seven donors had an uneventful postoperative course and were discharged on day 4 to 7 postoperatively. They have all resumed normal day-to-day activities. There were no complications in the donor group. A variety of complications occurred in the recipients, all of which were overcome. Operating microscope was used to perform all the arterial anastomoses using microvascular techniques. This method has proven to be a major factor in preventing arterial thrombosis even with the smallest of arterial anastomosis where a 1.5-mm diameter recipient artery was anastomosed to a 2.5-mm diameter donor hepatic artery.
 
ISSN0022-3468
2013 Impact Factor: 1.311
2013 SCImago Journal Rankings: 0.811
 
DOIhttp://dx.doi.org/10.1016/S0022-3468(97)90100-7
 
ISI Accession Number IDWOS:A1997WE27500023
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorSaing, H
 
dc.contributor.authorFan, ST
 
dc.contributor.authorChan, KL
 
dc.contributor.authorWei, WI
 
dc.contributor.authorLo, CM
 
dc.contributor.authorMya, GH
 
dc.contributor.authorTsoi, NS
 
dc.contributor.authorYuen, KY
 
dc.contributor.authorNg, IOL
 
dc.contributor.authorLo, JWR
 
dc.contributor.authorChau, MT
 
dc.contributor.authorTsoi, WK
 
dc.contributor.authorChan, J
 
dc.contributor.authorWong, J
 
dc.date.accessioned2012-05-29T06:12:40Z
 
dc.date.available2012-05-29T06:12:40Z
 
dc.date.issued1997
 
dc.description.abstractSeven living-related liver transplants (LRLT) and two reduced-size liver transplants (RSLT) were performed on eight children who suffered from end- stage liver disease, having previously undergone one to three abdominal operations. Their ages at initial transplantation ranged from 8 months to 11 years (mean 35 months, median 12 months). Excluding the two older children aged 7 and 11 years, respectively, the rest of the children weighed 6 to 9.5 kg (mean 7.3 kg) at the time of the initial transplantation. Seven left lateral segments (S2 + 3) and two left lobes (S2 + 3 + 4) were used; of these the smallest graft had a graft-to-recipient body weight ratio of 0.9%. The volunteer living donors were four mothers, two fathers and one sister who were selected after medical and psychiatric evaluations, and their suitability was confirmed by hematological, biochemical, and radiological criteria. During a follow-up period of 3 to 30 months, all eight children are alive and well with normal liver function, one of them having undergone a retransplant LRLT because of hepatitis of undetermined etiology following a RSLT 1.5 years earlier. All seven donors had an uneventful postoperative course and were discharged on day 4 to 7 postoperatively. They have all resumed normal day-to-day activities. There were no complications in the donor group. A variety of complications occurred in the recipients, all of which were overcome. Operating microscope was used to perform all the arterial anastomoses using microvascular techniques. This method has proven to be a major factor in preventing arterial thrombosis even with the smallest of arterial anastomosis where a 1.5-mm diameter recipient artery was anastomosed to a 2.5-mm diameter donor hepatic artery.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Pediatric Surgery, 1997, v. 32 n. 1, p. 80-83 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0022-3468(97)90100-7
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0022-3468(97)90100-7
 
dc.identifier.epage83
 
dc.identifier.hkuros24212
 
dc.identifier.isiWOS:A1997WE27500023
 
dc.identifier.issn0022-3468
2013 Impact Factor: 1.311
2013 SCImago Journal Rankings: 0.811
 
dc.identifier.issue1
 
dc.identifier.pmid9021576
 
dc.identifier.scopuseid_2-s2.0-12644305893
 
dc.identifier.spage80
 
dc.identifier.urihttp://hdl.handle.net/10722/148389
 
dc.identifier.volume32
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
 
dc.publisher.placeUnited States
 
dc.relation.ispartofJournal of Pediatric Surgery
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshActivities Of Daily Living
 
dc.subject.meshAnastomosis, Surgical - Methods
 
dc.subject.meshBody Weight
 
dc.subject.meshChild
 
dc.subject.meshChild, Preschool
 
dc.subject.meshFemale
 
dc.subject.meshFollow-Up Studies
 
dc.subject.meshGraft Survival
 
dc.subject.meshHepatic Artery - Surgery
 
dc.subject.meshHepatitis - Surgery
 
dc.subject.meshHistocompatibility
 
dc.subject.meshHong Kong - Epidemiology
 
dc.subject.meshHumans
 
dc.subject.meshInfant
 
dc.subject.meshLiver Failure - Surgery
 
dc.subject.meshLiver Transplantation - Adverse Effects - Methods - Pathology - Statistics & Numerical Data
 
dc.subject.meshLiving Donors - Classification
 
dc.subject.meshMale
 
dc.subject.meshMicrosurgery
 
dc.subject.meshOrgan Size
 
dc.subject.meshPostoperative Complications - Prevention & Control - Surgery
 
dc.subject.meshReoperation
 
dc.subject.meshSurvival Rate
 
dc.subject.meshThrombosis - Prevention & Control
 
dc.subject.meshTreatment Outcome
 
dc.subject.meshVascular Surgical Procedures - Methods
 
dc.subjectbiliary atresia
 
dc.subjectLiving-related liver transplantation
 
dc.subjectmicrovascular anastomosis
 
dc.subjectreduced-size liver transplantation
 
dc.titleLiver transplantation in children: The experience of Queen Mary Hospital, Hong Kong
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong