Article: Liver transplantation in children: The experience of Queen Mary Hospital, Hong Kong

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TitleLiver transplantation in children: The experience of Queen Mary Hospital, Hong Kong
AuthorsSaing, H1
Fan, ST
Chan, KL
Wei, WI
Lo, CM
Mya, GH
Tsoi, NS
Yuen, KY
Ng, IOL
Lo, JWR
Chau, MT
Tsoi, WK
Chan, J
Wong, J
Keywordsbiliary atresia
Living-related liver transplantation
microvascular anastomosis
reduced-size liver transplantation
Issue Date1997
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
CitationJournal Of Pediatric Surgery, 1997, v. 32 n. 1, p. 80-83 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0022-3468(97)90100-7
AbstractSeven living-related liver transplants (LRLT) and two reduced-size liver transplants (RSLT) were performed on eight children who suffered from end- stage liver disease, having previously undergone one to three abdominal operations. Their ages at initial transplantation ranged from 8 months to 11 years (mean 35 months, median 12 months). Excluding the two older children aged 7 and 11 years, respectively, the rest of the children weighed 6 to 9.5 kg (mean 7.3 kg) at the time of the initial transplantation. Seven left lateral segments (S2 + 3) and two left lobes (S2 + 3 + 4) were used; of these the smallest graft had a graft-to-recipient body weight ratio of 0.9%. The volunteer living donors were four mothers, two fathers and one sister who were selected after medical and psychiatric evaluations, and their suitability was confirmed by hematological, biochemical, and radiological criteria. During a follow-up period of 3 to 30 months, all eight children are alive and well with normal liver function, one of them having undergone a retransplant LRLT because of hepatitis of undetermined etiology following a RSLT 1.5 years earlier. All seven donors had an uneventful postoperative course and were discharged on day 4 to 7 postoperatively. They have all resumed normal day-to-day activities. There were no complications in the donor group. A variety of complications occurred in the recipients, all of which were overcome. Operating microscope was used to perform all the arterial anastomoses using microvascular techniques. This method has proven to be a major factor in preventing arterial thrombosis even with the smallest of arterial anastomosis where a 1.5-mm diameter recipient artery was anastomosed to a 2.5-mm diameter donor hepatic artery.
ISSN0022-3468
2011 Impact Factor: 1.45
2011 SCImago Journal Rankings: 0.114
DOIhttp://dx.doi.org/10.1016/S0022-3468(97)90100-7
ISI Accession Number IDWOS:A1997WE27500023
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorSaing, H
dc.contributor.authorFan, ST
dc.contributor.authorChan, KL
dc.contributor.authorWei, WI
dc.contributor.authorLo, CM
dc.contributor.authorMya, GH
dc.contributor.authorTsoi, NS
dc.contributor.authorYuen, KY
dc.contributor.authorNg, IOL
dc.contributor.authorLo, JWR
dc.contributor.authorChau, MT
dc.contributor.authorTsoi, WK
dc.contributor.authorChan, J
dc.contributor.authorWong, J
dc.date.accessioned2012-05-29T06:12:40Z
dc.date.available2012-05-29T06:12:40Z
dc.date.issued1997
dc.description.abstractSeven living-related liver transplants (LRLT) and two reduced-size liver transplants (RSLT) were performed on eight children who suffered from end- stage liver disease, having previously undergone one to three abdominal operations. Their ages at initial transplantation ranged from 8 months to 11 years (mean 35 months, median 12 months). Excluding the two older children aged 7 and 11 years, respectively, the rest of the children weighed 6 to 9.5 kg (mean 7.3 kg) at the time of the initial transplantation. Seven left lateral segments (S2 + 3) and two left lobes (S2 + 3 + 4) were used; of these the smallest graft had a graft-to-recipient body weight ratio of 0.9%. The volunteer living donors were four mothers, two fathers and one sister who were selected after medical and psychiatric evaluations, and their suitability was confirmed by hematological, biochemical, and radiological criteria. During a follow-up period of 3 to 30 months, all eight children are alive and well with normal liver function, one of them having undergone a retransplant LRLT because of hepatitis of undetermined etiology following a RSLT 1.5 years earlier. All seven donors had an uneventful postoperative course and were discharged on day 4 to 7 postoperatively. They have all resumed normal day-to-day activities. There were no complications in the donor group. A variety of complications occurred in the recipients, all of which were overcome. Operating microscope was used to perform all the arterial anastomoses using microvascular techniques. This method has proven to be a major factor in preventing arterial thrombosis even with the smallest of arterial anastomosis where a 1.5-mm diameter recipient artery was anastomosed to a 2.5-mm diameter donor hepatic artery.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Pediatric Surgery, 1997, v. 32 n. 1, p. 80-83 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0022-3468(97)90100-7
dc.identifier.doihttp://dx.doi.org/10.1016/S0022-3468(97)90100-7
dc.identifier.epage83
dc.identifier.hkuros24212
dc.identifier.isiWOS:A1997WE27500023
dc.identifier.issn0022-3468
2011 Impact Factor: 1.45
2011 SCImago Journal Rankings: 0.114
dc.identifier.issue1
dc.identifier.pmid9021576
dc.identifier.scopuseid_2-s2.0-12644305893
dc.identifier.spage80
dc.identifier.urihttp://hdl.handle.net/10722/148389
dc.identifier.volume32
dc.languageeng
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/jpedsurg
dc.publisher.placeUnited States
dc.relation.ispartofJournal of Pediatric Surgery
dc.relation.referencesReferences in Scopus
dc.subject.meshActivities Of Daily Living
dc.subject.meshAnastomosis, Surgical - Methods
dc.subject.meshBody Weight
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshGraft Survival
dc.subject.meshHepatic Artery - Surgery
dc.subject.meshHepatitis - Surgery
dc.subject.meshHistocompatibility
dc.subject.meshHong Kong - Epidemiology
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshLiver Failure - Surgery
dc.subject.meshLiver Transplantation - Adverse Effects - Methods - Pathology - Statistics & Numerical Data
dc.subject.meshLiving Donors - Classification
dc.subject.meshMale
dc.subject.meshMicrosurgery
dc.subject.meshOrgan Size
dc.subject.meshPostoperative Complications - Prevention & Control - Surgery
dc.subject.meshReoperation
dc.subject.meshSurvival Rate
dc.subject.meshThrombosis - Prevention & Control
dc.subject.meshTreatment Outcome
dc.subject.meshVascular Surgical Procedures - Methods
dc.subjectbiliary atresia
dc.subjectLiving-related liver transplantation
dc.subjectmicrovascular anastomosis
dc.subjectreduced-size liver transplantation
dc.titleLiver transplantation in children: The experience of Queen Mary Hospital, Hong Kong
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong