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Article: Magnetic resonance screening of iron status in transfusion-dependent β-thalassaemia patients

TitleMagnetic resonance screening of iron status in transfusion-dependent β-thalassaemia patients
Authors
KeywordsIron overload
Liver iron concentration
Magnetic resonance imaging
Signal intensity threshold
Treatment
Issue Date2004
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2004, v. 124 n. 3, p. 385-390 How to Cite?
AbstractThe clinical utility of dual sequence (T1- and T2-weighted) magnetic resonance (MR) imaging in estimating liver iron concentration (LIC) in 32 transfusion-dependent β-thalassaemia major (24 females; age 18.5±5. 9 years) patients on desferrioxamine was evaluated. Signal intensity ratios (SIR) between liver, spleen and pancreas to psoas muscle were determined on both sequences. Relationships between clinical and MR parameters, and accuracy of SIR thresholds in determining adequacy of chelation from LIC were analysed. Liver T1- and T2-SIR were related to LIC (P < 0.001). T1-SIR < 0.60 predicted severe iron overload (LIC > 15 mg/g) with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100%, 87%, 33% and 100% respectively. T2-SIR < 0.1 yielded 100% sensitivity, 93% specificity, 50% PPV and 100% NPV. T1-SIR ≥ 1.1 predicted LIC < 7 mg/g with 69% sensitivity, 88% specificity, 85% PPV and 74% NPV. T2-SIR ≥ 0.20 yielded 56.5% sensitivity, 94% specificity, 90% PPV and 71% NPV. LIC correlated with liver T1-SIR, liver T2-SIR and serum ferritin (r = -0.76, -0.65, 0.47, respectively; P < 0.01). Serum ferritin was inversely related to liver T1-SIR, liver T2-SIR and spleen T2-SIR (r = -0.35, -0.43, -0.40, respectively; P < 0.05). Mean total transfusion burden was not related to any MR parameter. Although neither MR sequence was a highly accurate predictor of LIC, SIR thresholds are useful to determine presence of iron overload and adequacy of chelation treatment.
Persistent Identifierhttp://hdl.handle.net/10722/148371
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOoi, GCen_HK
dc.contributor.authorKhong, PLen_HK
dc.contributor.authorChan, GCFen_HK
dc.contributor.authorChan, KNen_HK
dc.contributor.authorChan, KLen_HK
dc.contributor.authorLam, Wen_HK
dc.contributor.authorNg, Ien_HK
dc.contributor.authorHa, SYen_HK
dc.date.accessioned2012-05-29T06:12:32Z-
dc.date.available2012-05-29T06:12:32Z-
dc.date.issued2004en_HK
dc.identifier.citationBritish Journal Of Haematology, 2004, v. 124 n. 3, p. 385-390en_HK
dc.identifier.issn0007-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148371-
dc.description.abstractThe clinical utility of dual sequence (T1- and T2-weighted) magnetic resonance (MR) imaging in estimating liver iron concentration (LIC) in 32 transfusion-dependent β-thalassaemia major (24 females; age 18.5±5. 9 years) patients on desferrioxamine was evaluated. Signal intensity ratios (SIR) between liver, spleen and pancreas to psoas muscle were determined on both sequences. Relationships between clinical and MR parameters, and accuracy of SIR thresholds in determining adequacy of chelation from LIC were analysed. Liver T1- and T2-SIR were related to LIC (P < 0.001). T1-SIR < 0.60 predicted severe iron overload (LIC > 15 mg/g) with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 100%, 87%, 33% and 100% respectively. T2-SIR < 0.1 yielded 100% sensitivity, 93% specificity, 50% PPV and 100% NPV. T1-SIR ≥ 1.1 predicted LIC < 7 mg/g with 69% sensitivity, 88% specificity, 85% PPV and 74% NPV. T2-SIR ≥ 0.20 yielded 56.5% sensitivity, 94% specificity, 90% PPV and 71% NPV. LIC correlated with liver T1-SIR, liver T2-SIR and serum ferritin (r = -0.76, -0.65, 0.47, respectively; P < 0.01). Serum ferritin was inversely related to liver T1-SIR, liver T2-SIR and spleen T2-SIR (r = -0.35, -0.43, -0.40, respectively; P < 0.05). Mean total transfusion burden was not related to any MR parameter. Although neither MR sequence was a highly accurate predictor of LIC, SIR thresholds are useful to determine presence of iron overload and adequacy of chelation treatment.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_HK
dc.relation.ispartofBritish Journal of Haematologyen_HK
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subjectIron overloaden_HK
dc.subjectLiver iron concentrationen_HK
dc.subjectMagnetic resonance imagingen_HK
dc.subjectSignal intensity thresholden_HK
dc.subjectTreatmenten_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Transfusion - Adverse Effectsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshDeferoxamine - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshFerritins - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIron - Analysisen_US
dc.subject.meshIron Chelating Agents - Therapeutic Useen_US
dc.subject.meshIron Overload - Diagnosis - Etiologyen_US
dc.subject.meshLiver - Chemistry - Physiopathologyen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMyocardium - Chemistryen_US
dc.subject.meshPancreas - Chemistryen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSpleen - Chemistryen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshBeta-Thalassemia - Drug Therapy - Metabolism - Therapyen_US
dc.titleMagnetic resonance screening of iron status in transfusion-dependent β-thalassaemia patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailKhong, PL:plkhong@hkucc.hku.hken_HK
dc.identifier.emailChan, GCF:gcfchan@hkucc.hku.hken_HK
dc.identifier.emailNg, I:iolng@hkucc.hku.hken_HK
dc.identifier.authorityKhong, PL=rp00467en_HK
dc.identifier.authorityChan, GCF=rp00431en_HK
dc.identifier.authorityNg, I=rp00335en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2003.04772.xen_HK
dc.identifier.pmid14717788-
dc.identifier.scopuseid_2-s2.0-0842287261en_HK
dc.identifier.hkuros85603-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0842287261&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume124en_HK
dc.identifier.issue3en_HK
dc.identifier.spage385en_HK
dc.identifier.epage390en_HK
dc.identifier.isiWOS:000187958300017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOoi, GC=7006176119en_HK
dc.identifier.scopusauthoridKhong, PL=7006693233en_HK
dc.identifier.scopusauthoridChan, GCF=16160154400en_HK
dc.identifier.scopusauthoridChan, KN=15737866400en_HK
dc.identifier.scopusauthoridChan, KL=37004089600en_HK
dc.identifier.scopusauthoridLam, W=7203021937en_HK
dc.identifier.scopusauthoridNg, I=7102753722en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK

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