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Article: Identification of liver-intestine cadherin in hepatocellular carcinoma - A potential disease marker

TitleIdentification of liver-intestine cadherin in hepatocellular carcinoma - A potential disease marker
Authors
KeywordsDisease marker
Hepatocellular carcinoma
LI-cadherin
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2003, v. 311 n. 3, p. 618-624 How to Cite?
AbstractLiver-intestine cadherin (LI-cad) is a non-classical cadherin, which is expressed during intestinal development, but absent in normal liver tissue. Our earlier investigation has detected overexpression of LI-cad in gastric adenocarcinoma and indicated its association with lymph node metastasis. Herein, we found in RT-PCR and TaqMan Q-PCR that LI-cad was identified in HCC cell lines, HuH-7, Hep-3B, and PLC/PRF/5, but not in MIHA and HepG2 non-tumorigenic cells. Immunofluorescence cytochemistry assay revealed that the LI-cad was predominantly expressed in cytoplasm of HCC cells, contrary to that of E-cad immunostain at the plasma membrane region. By testing against 18 pairs of HCC and adjacent non-tumor tissues, 13 cases (72.2%) showed over expression of LI-cad in HCC tissues, 2 cases (11.1%) were similar, and 3 cases did not yield detectable signal. None of the 6 normal liver specimens tested was positive with LI-cad. Taken together, LI-cad could be a potential disease marker for HCC. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148360
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BWen_US
dc.contributor.authorLuk, JMen_US
dc.contributor.authorNg, IOen_US
dc.contributor.authorHu, MYen_US
dc.contributor.authorLiu, KDen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-05-29T06:12:28Z-
dc.date.available2012-05-29T06:12:28Z-
dc.date.issued2003en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2003, v. 311 n. 3, p. 618-624en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/148360-
dc.description.abstractLiver-intestine cadherin (LI-cad) is a non-classical cadherin, which is expressed during intestinal development, but absent in normal liver tissue. Our earlier investigation has detected overexpression of LI-cad in gastric adenocarcinoma and indicated its association with lymph node metastasis. Herein, we found in RT-PCR and TaqMan Q-PCR that LI-cad was identified in HCC cell lines, HuH-7, Hep-3B, and PLC/PRF/5, but not in MIHA and HepG2 non-tumorigenic cells. Immunofluorescence cytochemistry assay revealed that the LI-cad was predominantly expressed in cytoplasm of HCC cells, contrary to that of E-cad immunostain at the plasma membrane region. By testing against 18 pairs of HCC and adjacent non-tumor tissues, 13 cases (72.2%) showed over expression of LI-cad in HCC tissues, 2 cases (11.1%) were similar, and 3 cases did not yield detectable signal. None of the 6 normal liver specimens tested was positive with LI-cad. Taken together, LI-cad could be a potential disease marker for HCC. © 2003 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subjectDisease marker-
dc.subjectHepatocellular carcinoma-
dc.subjectLI-cadherin-
dc.subject.meshAgeden_US
dc.subject.meshCadherinsen_US
dc.subject.meshCarcinoma, Hepatocellular - Genetics - Metabolismen_US
dc.subject.meshCarrier Proteins - Biosynthesisen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCytoplasm - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Transport Proteinsen_US
dc.subject.meshMicroscopy, Fluorescenceen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshTumor Markers, Biologicalen_US
dc.titleIdentification of liver-intestine cadherin in hepatocellular carcinoma - A potential disease markeren_US
dc.typeArticleen_US
dc.identifier.emailLuk, JM:jmluk@hkucc.hku.hken_US
dc.identifier.emailNg, IO:iolng@hkucc.hku.hken_US
dc.identifier.emailFan, ST:stfan@hku.hken_US
dc.identifier.authorityLuk, JM=rp00349en_US
dc.identifier.authorityNg, IO=rp00335en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2003.10.032en_US
dc.identifier.pmid14623315-
dc.identifier.scopuseid_2-s2.0-0242577553en_US
dc.identifier.hkuros86090-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0242577553&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume311en_US
dc.identifier.issue3en_US
dc.identifier.spage618en_US
dc.identifier.epage624en_US
dc.identifier.isiWOS:000186643100010-
dc.publisher.placeUnited Statesen_US

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