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Article: Allele-specific chromosome 9p deletion in oral cancer

TitleAllele-specific chromosome 9p deletion in oral cancer
Authors
Issue Date2001
PublisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/
Citation
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 2001, v. 19 n. 5, p. 275-277 How to Cite?
AbstractOBJECTIVE: The aim of this study was to investigate the relationship between loss of heterozygosity (LOH) on chromosome 9p and the pathogenesis of oral squamous cell carcinoma (OSCC). METHODS: A total of 24 human OSCC specimens were analyzed for LOH on chromosome 9p using 8 microsatellite markers by means of polymerase chain reaction. RESULTS: In 24 cases of OSCC, LOH on chromosome 9p was identified in 10 of 24 cases (41.67%) with at least one marker. The main LOH were found on 9p21 at locus D9S171 (21.05%) and D9S304 (10.00%). There were also a deletion on 9p22-23 at locus D9S168 (22.22%) and D9S162 (15.38%). However, there was no statistically significant correlation between LOH at these loci with such clinical parameters as pathological types, tumor size and lymph-node metastasis. Microsatellite instability (MSI) is rare for any of the 8 markers in 24 OSCC. No MSI could observed using the common criteria for defining MSI-its detection in two or more markers. CONCLUSION: We found that high frequency of LOH occurred at 9p21-23 band. Their results indicate that more than one tumor suppressor genes at chromosome 9p21-23 region related to a subset of OSCC, while MSI might not be a crucial event.
Persistent Identifierhttp://hdl.handle.net/10722/148341
ISSN
2015 SCImago Journal Rankings: 0.121

 

DC FieldValueLanguage
dc.contributor.authorXiao, Len_US
dc.contributor.authorNg, IOen_US
dc.contributor.authorLuo, ZCen_US
dc.date.accessioned2012-05-29T06:12:20Z-
dc.date.available2012-05-29T06:12:20Z-
dc.date.issued2001en_US
dc.identifier.citationHua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 2001, v. 19 n. 5, p. 275-277en_US
dc.identifier.issn1000-1182en_US
dc.identifier.urihttp://hdl.handle.net/10722/148341-
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the relationship between loss of heterozygosity (LOH) on chromosome 9p and the pathogenesis of oral squamous cell carcinoma (OSCC). METHODS: A total of 24 human OSCC specimens were analyzed for LOH on chromosome 9p using 8 microsatellite markers by means of polymerase chain reaction. RESULTS: In 24 cases of OSCC, LOH on chromosome 9p was identified in 10 of 24 cases (41.67%) with at least one marker. The main LOH were found on 9p21 at locus D9S171 (21.05%) and D9S304 (10.00%). There were also a deletion on 9p22-23 at locus D9S168 (22.22%) and D9S162 (15.38%). However, there was no statistically significant correlation between LOH at these loci with such clinical parameters as pathological types, tumor size and lymph-node metastasis. Microsatellite instability (MSI) is rare for any of the 8 markers in 24 OSCC. No MSI could observed using the common criteria for defining MSI-its detection in two or more markers. CONCLUSION: We found that high frequency of LOH occurred at 9p21-23 band. Their results indicate that more than one tumor suppressor genes at chromosome 9p21-23 region related to a subset of OSCC, while MSI might not be a crucial event.en_US
dc.languageengen_US
dc.publisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/en_US
dc.relation.ispartofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 9 - Geneticsen_US
dc.subject.meshGenes, Tumor Suppressoren_US
dc.subject.meshHumansen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshMouth Neoplasms - Geneticsen_US
dc.titleAllele-specific chromosome 9p deletion in oral canceren_US
dc.typeArticleen_US
dc.identifier.emailNg, IO:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IO=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12539477-
dc.identifier.scopuseid_2-s2.0-0038532560en_US
dc.identifier.volume19en_US
dc.identifier.issue5en_US
dc.identifier.spage275en_US
dc.identifier.epage277en_US
dc.publisher.placeChinaen_US

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