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Article: Identify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumors

TitleIdentify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumors
Authors
Issue Date2002
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2002, v. 62 n. 16, p. 4711-4721 How to Cite?
AbstractDisease recurrence and metastasis are frequently observed in many successfully treated localized cancers, including hepatocellular carcinoma in which intrahepatic and extrahepatic recurrence (metastasis) are frequently observed after curative resection. The present study aimed at identifying metastasis-associated genes through delineation of the clonality for multinodular liver cancer. The clonal relationship of 22 tumor foci from six patients was investigated by the genome-wide expression profile via cDNA microarray consisting of 23,000 genes. Tumor molecular properties includingp53 protein overexpression and gene mutation, hepatitis B virus integration pattern, and genetic alteration examined by comparative genomic hybridization were compared. Results indicated that gene expression patterns could serve as the molecular fingerprint for clonality identification. Together with the molecular data from p53, hepatitis B virus integration and comparative genomic hybridization profiles, tumor nodules from five patients were confirmed with clonal relationship, and the expression profiles of the primary nodules were compared with their corresponding intrahepatic metastatic nodules. A total of 90 clones were found to be correlated with intrahepatic metastasis by Student's t test (P < 0.05). With reference to the primary tumor, 63 clones (39 known genes and 24 express sequence tags) were down-regulated whereas 27 clones (14 known genes and 13 express sequence tags) were up-regulated in the metastatic nodules. These metastasis-associated genes may provide clues to reveal patients with increased risk of developing metastasis, and to identify novel therapeutic targets for the treatment of metastasis.
Persistent Identifierhttp://hdl.handle.net/10722/148308
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, STen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorWong, SYen_HK
dc.contributor.authorTai, LSen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorSo, Sen_HK
dc.contributor.authorFan, STen_HK
dc.date.accessioned2012-05-29T06:12:08Z-
dc.date.available2012-05-29T06:12:08Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer Research, 2002, v. 62 n. 16, p. 4711-4721en_HK
dc.identifier.issn0008-5472en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148308-
dc.description.abstractDisease recurrence and metastasis are frequently observed in many successfully treated localized cancers, including hepatocellular carcinoma in which intrahepatic and extrahepatic recurrence (metastasis) are frequently observed after curative resection. The present study aimed at identifying metastasis-associated genes through delineation of the clonality for multinodular liver cancer. The clonal relationship of 22 tumor foci from six patients was investigated by the genome-wide expression profile via cDNA microarray consisting of 23,000 genes. Tumor molecular properties includingp53 protein overexpression and gene mutation, hepatitis B virus integration pattern, and genetic alteration examined by comparative genomic hybridization were compared. Results indicated that gene expression patterns could serve as the molecular fingerprint for clonality identification. Together with the molecular data from p53, hepatitis B virus integration and comparative genomic hybridization profiles, tumor nodules from five patients were confirmed with clonal relationship, and the expression profiles of the primary nodules were compared with their corresponding intrahepatic metastatic nodules. A total of 90 clones were found to be correlated with intrahepatic metastasis by Student's t test (P < 0.05). With reference to the primary tumor, 63 clones (39 known genes and 24 express sequence tags) were down-regulated whereas 27 clones (14 known genes and 13 express sequence tags) were up-regulated in the metastatic nodules. These metastasis-associated genes may provide clues to reveal patients with increased risk of developing metastasis, and to identify novel therapeutic targets for the treatment of metastasis.en_HK
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/en_HK
dc.relation.ispartofCancer Researchen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular - Genetics - Metabolism - Pathology - Secondaryen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGenes, P53en_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Genetics - Metabolism - Pathology - Secondaryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshNucleic Acid Hybridization - Methodsen_US
dc.subject.meshOligonucleotide Array Sequence Analysisen_US
dc.subject.meshTumor Suppressor Protein P53 - Biosynthesis - Geneticsen_US
dc.subject.meshVirus Integrationen_US
dc.titleIdentify metastasis-associated genes in hepatocellular carcinoma through clonality delineation for multinodular tumorsen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ST:stcheung@hkucc.hku.hken_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailFan, ST:stfan@hku.hken_HK
dc.identifier.authorityCheung, ST=rp00457en_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12183430-
dc.identifier.scopuseid_2-s2.0-0037102254en_HK
dc.identifier.hkuros79363-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037102254&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue16en_HK
dc.identifier.spage4711en_HK
dc.identifier.epage4721en_HK
dc.identifier.isiWOS:000177496600031-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, ST=7202473497en_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridWong, SY=7404590342en_HK
dc.identifier.scopusauthoridTai, LS=7004457333en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridSo, S=7102397384en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK

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