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Article: p53, p21, Rb, and MDM2 proteins in tongue carcinoma from patients <35 versus >75 years

Titlep53, p21, Rb, and MDM2 proteins in tongue carcinoma from patients <35 versus >75 years
Authors
Issue Date1999
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncology
Citation
Oral Oncology, 1999, v. 35 n. 4, p. 379-383 How to Cite?
AbstractRelatively rare squamous cell carcinomas of the tongue in young patients may be associated with different etiologic factors and pathogenetic mechanisms than carcinomas from the same site in older patients. Alterations in cell cycle proteins likely contribute to the biologic behavior of these neoplasms. The purpose of this investigation was to evaluate cell cycle proteins (p53, p21, Rb, MDM2) in lateral tongue cancers from patients at the two ends of the age spectrum. All available archived lateral tongue carcinomas from patients <35 years (n = 36, 23 males and 13 females) were sectioned, immunohistochemically stained, and evaluated. Protein expression was scored as percent positive nuclei. An equal number of sequentially accessioned lateral tongue specimens from patients >75 years (23 males and 13 females) were stained and compared. Positive p53 staining was seen in 18/36 of the <35-year group versus 24/36 of the >75-year group (p = 0.149). Increased p21 staining (both percent of positive cells and intensity) was evident in 25/32 of the <35-year group versus 24/32 of the >75-year group (p = 1.0). Increased p21 expression was seen in both p53-positive and -negative cases in both age groups. Rb protein was increased in 16/29 of the <35-year group versus 17/26 of the >75-year group (p = 0.58). Fourteen cases (4/35 vs 10/36, p = 0.135) showed positive MDM2 staining; MDM2-positive cases were also p53 positive in 4/4 younger and 8/10 older patients. We conclude that p53, p21, Rb, and MDM2 are over-expressed in lateral tongue cancers, and that immunohistochemical profiles are heterogeneous. A p53-independent pathway of p21 induction is supported by the results; p53 suppression may be associated with MDM2 protein expression in a subset of cancers. Significant differences in the expression of p53, p21, Rb, and MDM2 proteins are not evident in lateral tongue carcinomas from patients <35 years as compared to patients >75 years.
Persistent Identifierhttp://hdl.handle.net/10722/148168
ISSN
2015 Impact Factor: 4.286
2015 SCImago Journal Rankings: 1.764
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRegezi, JAen_US
dc.contributor.authorDekker, NPen_US
dc.contributor.authorMcMillan, Aen_US
dc.contributor.authorRamirez-Amador, Ven_US
dc.contributor.authorMeneses-Garcia, Aen_US
dc.contributor.authorRuiz-Godoy Rivera, LMen_US
dc.contributor.authorChrysomali, Een_US
dc.contributor.authorNg, IOLen_US
dc.date.accessioned2012-05-29T06:11:13Z-
dc.date.available2012-05-29T06:11:13Z-
dc.date.issued1999en_US
dc.identifier.citationOral Oncology, 1999, v. 35 n. 4, p. 379-383en_US
dc.identifier.issn1368-8375en_US
dc.identifier.urihttp://hdl.handle.net/10722/148168-
dc.description.abstractRelatively rare squamous cell carcinomas of the tongue in young patients may be associated with different etiologic factors and pathogenetic mechanisms than carcinomas from the same site in older patients. Alterations in cell cycle proteins likely contribute to the biologic behavior of these neoplasms. The purpose of this investigation was to evaluate cell cycle proteins (p53, p21, Rb, MDM2) in lateral tongue cancers from patients at the two ends of the age spectrum. All available archived lateral tongue carcinomas from patients <35 years (n = 36, 23 males and 13 females) were sectioned, immunohistochemically stained, and evaluated. Protein expression was scored as percent positive nuclei. An equal number of sequentially accessioned lateral tongue specimens from patients >75 years (23 males and 13 females) were stained and compared. Positive p53 staining was seen in 18/36 of the <35-year group versus 24/36 of the >75-year group (p = 0.149). Increased p21 staining (both percent of positive cells and intensity) was evident in 25/32 of the <35-year group versus 24/32 of the >75-year group (p = 1.0). Increased p21 expression was seen in both p53-positive and -negative cases in both age groups. Rb protein was increased in 16/29 of the <35-year group versus 17/26 of the >75-year group (p = 0.58). Fourteen cases (4/35 vs 10/36, p = 0.135) showed positive MDM2 staining; MDM2-positive cases were also p53 positive in 4/4 younger and 8/10 older patients. We conclude that p53, p21, Rb, and MDM2 are over-expressed in lateral tongue cancers, and that immunohistochemical profiles are heterogeneous. A p53-independent pathway of p21 induction is supported by the results; p53 suppression may be associated with MDM2 protein expression in a subset of cancers. Significant differences in the expression of p53, p21, Rb, and MDM2 proteins are not evident in lateral tongue carcinomas from patients <35 years as compared to patients >75 years.en_US
dc.languageengen_US
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/oraloncologyen_US
dc.relation.ispartofOral Oncologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshCarcinoma, Squamous Cell - Metabolismen_US
dc.subject.meshCyclin-Dependent Kinase Inhibitor P21en_US
dc.subject.meshCyclins - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasm Proteins - Metabolismen_US
dc.subject.meshNuclear Proteinsen_US
dc.subject.meshProto-Oncogene Proteins - Metabolismen_US
dc.subject.meshProto-Oncogene Proteins C-Mdm2en_US
dc.subject.meshRetinoblastoma Protein - Metabolismen_US
dc.subject.meshTongue Neoplasms - Metabolismen_US
dc.subject.meshTumor Suppressor Protein P53 - Metabolismen_US
dc.titlep53, p21, Rb, and MDM2 proteins in tongue carcinoma from patients <35 versus >75 yearsen_US
dc.typeArticleen_US
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1368-8375(98)00126-2en_US
dc.identifier.pmid10645402en_US
dc.identifier.scopuseid_2-s2.0-0033168334en_US
dc.identifier.hkuros43028-
dc.identifier.hkuros56454-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033168334&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume35en_US
dc.identifier.issue4en_US
dc.identifier.spage379en_US
dc.identifier.epage383en_US
dc.identifier.isiWOS:000080910100006-
dc.publisher.placeUnited Kingdomen_US

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