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Article: Vascular endothelial growth factor is up-regulated in the early pre- malignant stage of colorectal tumour progression

TitleVascular endothelial growth factor is up-regulated in the early pre- malignant stage of colorectal tumour progression
Authors
Issue Date1999
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1999, v. 81 n. 6, p. 845-850 How to Cite?
AbstractAngiogenesis is an essential requirement for the development, progression and metastasis of malignant tumours. Studies on transgenic mouse models have shown that angiogenesis begins in the pre-malignant phase of oncogenesis, when dysplastic lesions acquire an increased microvasculature. To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and colorectal tumour progression, we have studied VEGF expression level and splice variant pattern by semi-quantitative RT-PCR and the cellular source of VEGF expression by in situ hybrization (ISH) in a range of lesions that modelled the tumour-development pathway from normal colon to invasive colorectal adenocarcinomas. Colonic adenomas showed a statistically significant up-regulation of VEGF expression over normal tissues, with a further increase during the development of adenocarcinomas. Tumour cells formed the major source of VEGF expression, with a minor contribution from mononuclear cells in the tumour stroma and enhanced expression in tumour cells around necrotic regions. The comparable expression level in both the in situ and invasive components in the same tumours indicated that a high VEGF expression capacity had been acquired prior to establishment of the invasive phenotype. Our findings support activation of VEGF as the molecular basis for the discrete induction of angiogenesis in the pre-malignant phase of colorectal tumour development.
Persistent Identifierhttp://hdl.handle.net/10722/148163
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, MPen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorYuen, STen_US
dc.contributor.authorLeung, SYen_US
dc.contributor.authorChung, LPen_US
dc.date.accessioned2012-05-29T06:11:11Z-
dc.date.available2012-05-29T06:11:11Z-
dc.date.issued1999en_US
dc.identifier.citationInternational Journal Of Cancer, 1999, v. 81 n. 6, p. 845-850en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/148163-
dc.description.abstractAngiogenesis is an essential requirement for the development, progression and metastasis of malignant tumours. Studies on transgenic mouse models have shown that angiogenesis begins in the pre-malignant phase of oncogenesis, when dysplastic lesions acquire an increased microvasculature. To investigate the relationship between the expression of vascular endothelial growth factor (VEGF) and colorectal tumour progression, we have studied VEGF expression level and splice variant pattern by semi-quantitative RT-PCR and the cellular source of VEGF expression by in situ hybrization (ISH) in a range of lesions that modelled the tumour-development pathway from normal colon to invasive colorectal adenocarcinomas. Colonic adenomas showed a statistically significant up-regulation of VEGF expression over normal tissues, with a further increase during the development of adenocarcinomas. Tumour cells formed the major source of VEGF expression, with a minor contribution from mononuclear cells in the tumour stroma and enhanced expression in tumour cells around necrotic regions. The comparable expression level in both the in situ and invasive components in the same tumours indicated that a high VEGF expression capacity had been acquired prior to establishment of the invasive phenotype. Our findings support activation of VEGF as the molecular basis for the discrete induction of angiogenesis in the pre-malignant phase of colorectal tumour development.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.-
dc.subject.meshAdenocarcinoma - Genetics - Metabolism - Pathologyen_US
dc.subject.meshAdenoma - Genetics - Metabolism - Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnimalsen_US
dc.subject.meshCarcinoma - Genetics - Metabolism - Pathologyen_US
dc.subject.meshColon - Metabolism - Pathologyen_US
dc.subject.meshColonic Neoplasms - Genetics - Metabolism - Pathologyen_US
dc.subject.meshColorectal Neoplasms - Genetics - Metabolism - Pathologyen_US
dc.subject.meshDisease Progressionen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrecancerous Conditions - Genetics - Metabolism - Pathologyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.titleVascular endothelial growth factor is up-regulated in the early pre- malignant stage of colorectal tumour progressionen_US
dc.typeArticleen_US
dc.identifier.emailWong, MP:mwpik@hkucc.hku.hken_US
dc.identifier.emailLeung, SY:suetyi@hkucc.hku.hken_US
dc.identifier.authorityWong, MP=rp00348en_US
dc.identifier.authorityLeung, SY=rp00359en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0215(19990611)81:6<845::AID-IJC1>3.0.CO;2-5en_US
dc.identifier.pmid10362127-
dc.identifier.scopuseid_2-s2.0-0033010512en_US
dc.identifier.hkuros45307-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033010512&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue6en_US
dc.identifier.spage845en_US
dc.identifier.epage850en_US
dc.identifier.isiWOS:000080581200001-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWong, MP=7403907887-
dc.identifier.scopusauthoridCheung, N=36803314200-
dc.identifier.scopusauthoridYuen, ST=7103160927-
dc.identifier.scopusauthoridLeung, SY=7202044886-
dc.identifier.scopusauthoridChung, LP=24315879100-

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