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Article: β-Fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with Type II diabetes

Titleβ-Fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with Type II diabetes
Other TitlesBeta-fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with type II diabetes
Authors
KeywordsFibrinogen
Gene
Ischaemic heart disease
Polymorphism
Type II diabetes
Issue Date1999
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
Citation
Diabetologia, 1999, v. 42 n. 10, p. 1250-1253 How to Cite?
AbstractAims/hypothesis. We investigated the relation between the G/A-455 (Hae III) β-fibrinogen gene polymorphism and plasma fibrinogen concentration and its role in ischaemic heart disease in 264 Chinese patients with Type II (non-insulin-dependent) diabetes mellitus and 182 non-diabetic control subjects. Methods. The G/A-455 polymorphism was determined in genomic DNA using polymerase chain reaction and Hae III restriction enzyme digestion. Fibrinogen was measured with the Claus method. Results. Fibrinogen concentrations were higher in diabetic patients (3.3±0.5 vs 2.5±0.9 g/l in controls, p < 0.0001) and in women (p < 0.03 vs men). Allele frequency of the variant A allele was 27% in both diabetic patients and control subjects' similar to findings in Caucasians. In control subjects, the AA genotype was associated with higher fibrinogen concentrations (2.8±0.38 g/l vs 2.5±0.5 in GG or GA, p < 0.03), contributing to 4% of the variance in plasma fibrinogen. The genotype effect was smaller and not significant among non- smokers, women and diabetic patients. Higher fibrinogen concentrations and AA genotype frequency were found in diabetic patients with ischaemic heart disease (p < 0.05 and p < 0.005, respectively vs unaffected patients). In a multiple logistic regression model, AA genotype, age and mean arterial pressure were associated with ischaemic heart disease, with odds ratios of 4.19 (p < 0.01), 1.05 (p < 0.0001) and 1.03 (p < 0.03), respectively. Conclusion/interpretation. The G/A-455 polymorphism is a genetic determinant of fibrinogen concentrations and ischaemic heart disease in this Chinese cohort. It also interacts with environmental influences associated with smoking, the female sex and Type II diabetes in determining plasma fibrinogen concentrations.
Persistent Identifierhttp://hdl.handle.net/10722/148142
ISSN
2015 Impact Factor: 6.206
2015 SCImago Journal Rankings: 3.528
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorMa, OCKen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorJanus, EDen_HK
dc.date.accessioned2012-05-29T06:11:05Z-
dc.date.available2012-05-29T06:11:05Z-
dc.date.issued1999en_HK
dc.identifier.citationDiabetologia, 1999, v. 42 n. 10, p. 1250-1253en_HK
dc.identifier.issn0012-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/148142-
dc.description.abstractAims/hypothesis. We investigated the relation between the G/A-455 (Hae III) β-fibrinogen gene polymorphism and plasma fibrinogen concentration and its role in ischaemic heart disease in 264 Chinese patients with Type II (non-insulin-dependent) diabetes mellitus and 182 non-diabetic control subjects. Methods. The G/A-455 polymorphism was determined in genomic DNA using polymerase chain reaction and Hae III restriction enzyme digestion. Fibrinogen was measured with the Claus method. Results. Fibrinogen concentrations were higher in diabetic patients (3.3±0.5 vs 2.5±0.9 g/l in controls, p < 0.0001) and in women (p < 0.03 vs men). Allele frequency of the variant A allele was 27% in both diabetic patients and control subjects' similar to findings in Caucasians. In control subjects, the AA genotype was associated with higher fibrinogen concentrations (2.8±0.38 g/l vs 2.5±0.5 in GG or GA, p < 0.03), contributing to 4% of the variance in plasma fibrinogen. The genotype effect was smaller and not significant among non- smokers, women and diabetic patients. Higher fibrinogen concentrations and AA genotype frequency were found in diabetic patients with ischaemic heart disease (p < 0.05 and p < 0.005, respectively vs unaffected patients). In a multiple logistic regression model, AA genotype, age and mean arterial pressure were associated with ischaemic heart disease, with odds ratios of 4.19 (p < 0.01), 1.05 (p < 0.0001) and 1.03 (p < 0.03), respectively. Conclusion/interpretation. The G/A-455 polymorphism is a genetic determinant of fibrinogen concentrations and ischaemic heart disease in this Chinese cohort. It also interacts with environmental influences associated with smoking, the female sex and Type II diabetes in determining plasma fibrinogen concentrations.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htmen_HK
dc.relation.ispartofDiabetologiaen_HK
dc.subjectFibrinogenen_HK
dc.subjectGeneen_HK
dc.subjectIschaemic heart diseaseen_HK
dc.subjectPolymorphismen_HK
dc.subjectType II diabetesen_HK
dc.subject.meshAge Factorsen_US
dc.subject.meshAllelesen_US
dc.subject.meshBody Mass Indexen_US
dc.subject.meshChinaen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Complications - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinogen - Genetics - Metabolismen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Linkageen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia - Blood - Complications - Geneticsen_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSmokingen_US
dc.titleβ-Fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with Type II diabetesen_HK
dc.title.alternativeBeta-fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with type II diabetes-
dc.typeArticleen_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s001250051300en_HK
dc.identifier.pmid10525668-
dc.identifier.scopuseid_2-s2.0-0032843432en_HK
dc.identifier.hkuros51229-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032843432&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume42en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1250en_HK
dc.identifier.epage1253en_HK
dc.identifier.isiWOS:000082935500015-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridMa, OCK=7004452841en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK

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