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Article: Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in chinese patients with Type II (non- insulin-dependent) diabetes mellitus

TitleGenetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in chinese patients with Type II (non- insulin-dependent) diabetes mellitus
Authors
KeywordsChinese
Diabetes mellitus
Environmental
Factor VII
Genetic
Issue Date1998
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htm
Citation
Diabetologia, 1998, v. 41 n. 7, p. 760-766 How to Cite?
AbstractWe studied the effects of genetic and environmental influences on factor VII coagulant activity (VIIc) in Chinese diabetic patients (263 with Type II [non-insulin-dependent] diabetes mellitus, 78 with Type I [insulin-dependent] diabetes mellitus) and 143 normal control subjects. VIIc was measured by a one-stage biological assay. The R/Q353 or Mspl polymorphism at codon 353 of the factor VII gene was detected after Mspl digestion of polymerase chain reaction-amplified genomic DNA. In both diabetic and control subjects the allele frequencies of the R (M1) and Q (M2) alleles were 0.96 and 0.04; the corresponding reported frequencies in Caucasians being 0.90 and 0.10: VIIc were 21% lower in Chinese control subjects and Type I diabetic patients with R/Q, compared with R/R subjects (p <0.001 and p < 0.05). The corresponding difference was 4 % for Type II diabetc patients (p = Ns). Type II diabetic patients had higher mean VIIc levels than control subjects and Type I diabetic patients (p < 0.01); they were also older, and had higher serum creatinine and triglyceride (all p < 0.01). They also had higher VIIc levels than an age-matched older control group (p < 0.01; n = 182) in whom the genotype effect was clearly seen. On stepwise linear regression analysis, the significant independent determinants of VIIc were serum triglyceride (contributing 20 % and 25 % to variance in control subjects and diabetic patients), the R/Q353 genotype (contributing to 12% of the variance in control subjects but only 1% in diabetic patients), age and total cholesterol in all subjects, and in the diabetic patients female sex, urinary albumin excretion rate and serum creatinine. VIIc was higher in diabetic patients with macroangiopathy and retinopathy (both p < 0.0001). We conclude that compared with Caucasians, the Q allele frequency is significantly lower in these Chinese subjects. Plasma Vllc is determined by both genetic and environmental influences such that in Chinese Type II diabetic patients, the effect of environmental factors predominates, almost negating the influence of the R/Q353 genotype. High VIIc may contribute to the increased cardiovascular risk in Type II diabetic patients.
Persistent Identifierhttp://hdl.handle.net/10722/148110
ISSN
2015 Impact Factor: 6.206
2015 SCImago Journal Rankings: 3.528
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KSLen_HK
dc.contributor.authorMa, OCKen_HK
dc.contributor.authorBourke, Cen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorJanus, EDen_HK
dc.date.accessioned2012-05-29T06:10:54Z-
dc.date.available2012-05-29T06:10:54Z-
dc.date.issued1998en_HK
dc.identifier.citationDiabetologia, 1998, v. 41 n. 7, p. 760-766en_HK
dc.identifier.issn0012-186Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/148110-
dc.description.abstractWe studied the effects of genetic and environmental influences on factor VII coagulant activity (VIIc) in Chinese diabetic patients (263 with Type II [non-insulin-dependent] diabetes mellitus, 78 with Type I [insulin-dependent] diabetes mellitus) and 143 normal control subjects. VIIc was measured by a one-stage biological assay. The R/Q353 or Mspl polymorphism at codon 353 of the factor VII gene was detected after Mspl digestion of polymerase chain reaction-amplified genomic DNA. In both diabetic and control subjects the allele frequencies of the R (M1) and Q (M2) alleles were 0.96 and 0.04; the corresponding reported frequencies in Caucasians being 0.90 and 0.10: VIIc were 21% lower in Chinese control subjects and Type I diabetic patients with R/Q, compared with R/R subjects (p <0.001 and p < 0.05). The corresponding difference was 4 % for Type II diabetc patients (p = Ns). Type II diabetic patients had higher mean VIIc levels than control subjects and Type I diabetic patients (p < 0.01); they were also older, and had higher serum creatinine and triglyceride (all p < 0.01). They also had higher VIIc levels than an age-matched older control group (p < 0.01; n = 182) in whom the genotype effect was clearly seen. On stepwise linear regression analysis, the significant independent determinants of VIIc were serum triglyceride (contributing 20 % and 25 % to variance in control subjects and diabetic patients), the R/Q353 genotype (contributing to 12% of the variance in control subjects but only 1% in diabetic patients), age and total cholesterol in all subjects, and in the diabetic patients female sex, urinary albumin excretion rate and serum creatinine. VIIc was higher in diabetic patients with macroangiopathy and retinopathy (both p < 0.0001). We conclude that compared with Caucasians, the Q allele frequency is significantly lower in these Chinese subjects. Plasma Vllc is determined by both genetic and environmental influences such that in Chinese Type II diabetic patients, the effect of environmental factors predominates, almost negating the influence of the R/Q353 genotype. High VIIc may contribute to the increased cardiovascular risk in Type II diabetic patients.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00125/index.htmen_HK
dc.relation.ispartofDiabetologiaen_HK
dc.subjectChineseen_HK
dc.subjectDiabetes mellitusen_HK
dc.subjectEnvironmentalen_HK
dc.subjectFactor VIIen_HK
dc.subjectGeneticen_HK
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshDna-Cytosine Methylasesen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Epidemiology - Geneticsen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Epidemiology - Geneticsen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshFactor Vii - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshLipids - Blooden_US
dc.subject.meshLipoproteins - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPoint Mutationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPolymorphism, Restriction Fragment Lengthen_US
dc.subject.meshRegression Analysisen_US
dc.titleGenetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in chinese patients with Type II (non- insulin-dependent) diabetes mellitusen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, KSL:ksllam@hku.hken_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s001250050984en_HK
dc.identifier.pmid9686915-
dc.identifier.scopuseid_2-s2.0-0031810986en_HK
dc.identifier.hkuros41714-
dc.identifier.hkuros41475-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031810986&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue7en_HK
dc.identifier.spage760en_HK
dc.identifier.epage766en_HK
dc.identifier.isiWOS:000074621500002-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.scopusauthoridMa, OCK=7004452841en_HK
dc.identifier.scopusauthoridBourke, C=7004240621en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK

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