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Article: Prevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese

TitlePrevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chinese
Authors
Issue Date1997
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1997, v. 72 n. 2, p. 225-230 How to Cite?
AbstractA specific variant of Epstein-Barr virus (EBV) with a 30-bp deletion in the C-terminal region of the LMPI gene has been found in some EBV-associated malignancies. To better understand the tumorigenic role of this LMPI variant, we used PCR and sequencing to examine the LMPI gene in 38 EBV-associated carcinomas (EBV-CAs) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and I metastatic NPC), 55 reactive lymphoid tissues from tonsils (TON) and 67 EBV-negative tumours in various organs (22 adenolymphoma of salivary gland, 14 gastric and 31 colonic adenocarcinomas), where the virus was demonstrated in lymphocytes. The TON showed prevalence of both deleted and non-deleted variants of LMPI, with dual infection being common. Significantly more of the LMPI variant was deleted in EBV-CA and in EBV-negative tumours. Sequencing showed that the deleted and non-deleted variants have different sets of amino acid mutation. Mutations in codon 344 and 355 in the non-deleted variant disrupted the 9 nucleotide repeat flanking the deletion and thus may have conferred resistance to the deletion. The prevalence of both variants in the TON, with enrichment for the deleted variant in various organs, argues for the existence of an immune selection pressure in our population. The deleted variant, which may have a higher tumorigenic potential, may contribute to the high incidence of NPC, as well as the occurrence of EBV-CA in organs outside the nasopharynx in our locality.
Persistent Identifierhttp://hdl.handle.net/10722/148078
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorChan, ASYen_HK
dc.contributor.authorWong, MPen_HK
dc.date.accessioned2012-05-29T06:10:43Z-
dc.date.available2012-05-29T06:10:43Z-
dc.date.issued1997en_HK
dc.identifier.citationInternational Journal Of Cancer, 1997, v. 72 n. 2, p. 225-230en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148078-
dc.description.abstractA specific variant of Epstein-Barr virus (EBV) with a 30-bp deletion in the C-terminal region of the LMPI gene has been found in some EBV-associated malignancies. To better understand the tumorigenic role of this LMPI variant, we used PCR and sequencing to examine the LMPI gene in 38 EBV-associated carcinomas (EBV-CAs) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and I metastatic NPC), 55 reactive lymphoid tissues from tonsils (TON) and 67 EBV-negative tumours in various organs (22 adenolymphoma of salivary gland, 14 gastric and 31 colonic adenocarcinomas), where the virus was demonstrated in lymphocytes. The TON showed prevalence of both deleted and non-deleted variants of LMPI, with dual infection being common. Significantly more of the LMPI variant was deleted in EBV-CA and in EBV-negative tumours. Sequencing showed that the deleted and non-deleted variants have different sets of amino acid mutation. Mutations in codon 344 and 355 in the non-deleted variant disrupted the 9 nucleotide repeat flanking the deletion and thus may have conferred resistance to the deletion. The prevalence of both variants in the TON, with enrichment for the deleted variant in various organs, argues for the existence of an immune selection pressure in our population. The deleted variant, which may have a higher tumorigenic potential, may contribute to the high incidence of NPC, as well as the occurrence of EBV-CA in organs outside the nasopharynx in our locality.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshChilden_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHong Kong - Ethnologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLymphoid Tissue - Pathology - Virologyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasms - Epidemiology - Genetics - Pathology - Virologyen_US
dc.subject.meshOncogene Proteins, Viral - Geneticsen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshViral Matrix Proteins - Geneticsen_US
dc.titlePrevalence of mutations and 30-bp deletion in the C-terminal region of Epstein-Barr virus latent membrane protein-1 oncogene in reactive lymphoid tissue and non-nasopharyngeal EBV-associated carcinomas in Hong Kong Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailWong, MP: mwpik@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityWong, MP=rp00348en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0215(19970717)72:2<225::AID-IJC4>3.0.CO;2-Ten_HK
dc.identifier.pmid9219824-
dc.identifier.scopuseid_2-s2.0-0030802192en_HK
dc.identifier.hkuros26131en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030802192&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume72en_HK
dc.identifier.issue2en_HK
dc.identifier.spage225en_HK
dc.identifier.epage230en_HK
dc.identifier.isiWOS:A1997XH81000004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridChan, ASY=55246984000en_HK
dc.identifier.scopusauthoridWong, MP=7403907887en_HK

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