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Article: High frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma vital oncogenes

TitleHigh frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma vital oncogenes
Authors
Issue Date1997
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 1997, v. 95 n. 2, p. 166-172 How to Cite?
AbstractViral oncogenes are commonly used to transform and extend the in vitro life span of human epithelial cells. We have established 7 cell lines of human ovarian surface epithelial cells using human papilloma vital oncogenes (HPV-EGE7 ORFs). Cytogenetic analysis of the cell lines revealed a high frequency of telomeric associations ranging from 30% to 100% of the metaphases examined. The short arms of chromosomes 16, 19, 21, and 22 showed a higher rote of telomeric association. Telomeric association with other chromosomal ends appears to be random. Fusion of 2 chromosomes ends may contribute to the genomic instability of transformed cells and lead to further genetic alterations involved in malignant transformation such as gene amplication and loss of heterozygosity. This is the first report describing a high frequency of telomeric associations in human ovarian epithelial cells transformed by HPV oncogenes.
Persistent Identifierhttp://hdl.handle.net/10722/148065
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWan, TSKen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorTsao, SWen_HK
dc.date.accessioned2012-05-29T06:10:39Z-
dc.date.available2012-05-29T06:10:39Z-
dc.date.issued1997en_HK
dc.identifier.citationCancer Genetics And Cytogenetics, 1997, v. 95 n. 2, p. 166-172en_HK
dc.identifier.issn0165-4608en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148065-
dc.description.abstractViral oncogenes are commonly used to transform and extend the in vitro life span of human epithelial cells. We have established 7 cell lines of human ovarian surface epithelial cells using human papilloma vital oncogenes (HPV-EGE7 ORFs). Cytogenetic analysis of the cell lines revealed a high frequency of telomeric associations ranging from 30% to 100% of the metaphases examined. The short arms of chromosomes 16, 19, 21, and 22 showed a higher rote of telomeric association. Telomeric association with other chromosomal ends appears to be random. Fusion of 2 chromosomes ends may contribute to the genomic instability of transformed cells and lead to further genetic alterations involved in malignant transformation such as gene amplication and loss of heterozygosity. This is the first report describing a high frequency of telomeric associations in human ovarian epithelial cells transformed by HPV oncogenes.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_HK
dc.relation.ispartofCancer Genetics and Cytogeneticsen_HK
dc.rightsCancer Genetics and Cytogenetics. Copyright © Elsevier Inc.-
dc.subject.meshCell Transformation, Neoplastic - Geneticsen_US
dc.subject.meshCell Transformation, Viral - Geneticsen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKaryotypingen_US
dc.subject.meshOncogenesen_US
dc.subject.meshOvary - Cytologyen_US
dc.subject.meshPapillomaviridae - Geneticsen_US
dc.subject.meshTelomereen_US
dc.titleHigh frequency of telomeric associations in human ovarian surface epithelial cells transformed by human papilloma vital oncogenesen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityTsao, SW=rp00399en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-4608(96)00245-2en_HK
dc.identifier.pmid9169036en_US
dc.identifier.scopuseid_2-s2.0-0030612664en_HK
dc.identifier.hkuros33459-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030612664&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue2en_HK
dc.identifier.spage166en_HK
dc.identifier.epage172en_HK
dc.identifier.isiWOS:A1997XA83100009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWan, TSK=25623981600en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridTsao, SW=7102813116en_HK

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