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Article: Prognostic significance of serum tumour markers in carcinoma of the cervix

TitlePrognostic significance of serum tumour markers in carcinoma of the cervix
Authors
KeywordsCarcinoma of the cervix
Prognostic factors
Tumour markers
Issue Date1996
PublisherI R O G Canada, Inc. The Journal's web site is located at http://www.irog.net/en-CA/index.aspx?CatID=4
Citation
European Journal Of Gynaecological Oncology, 1996, v. 17 n. 6, p. 512-517 How to Cite?
AbstractPurpose: The purpose was to evaluate the prognostic significance of serum tumour markers and other potential prognostic factors in cervical cancer. Materials and methods: Five hundred and thirty-one patients with cervical cancer were studied. The pre-treatment levels of SCC (squamous cell carcinoma antigen), TPA (tissue polypeptide antigen), CEA (carcinoembryonic antigen), CA125 and hCG (human chorionic gonadotrophin) were assayed in these patients. Possible association between raised tumour markers and potential prognostic factors and their prognostic significance were sought by univariate and multivariate Cox analysis. Results: SCC was raised in 65% of squamous cell carcinoma of the cervix and TPA was raised in 50%. Other markers were raised in less than 25%. No tumour markers were raised more than 30% in adenocarcinoma of the cervix. Raised SCC and TPA were related to advancing age, stage and grade of differentiation. Univariate analysis showed that age, stage, grade, raised SCC and TPA were significant prognostic factors on survival. Multivariate Cox analysis showed that stage was the most significant factor. Conclusion: Stage, age, grade of differentiation, raised pre-treatment levels of SCC and TPA were significant prognostic factors in cervical cancer using univariate analysis. However, only stage remains the most important independent prognostic factor in multivariate analysis. The prognostic value of these other factors in early stage disease needs further exploration.
Persistent Identifierhttp://hdl.handle.net/10722/148053
ISSN
2015 Impact Factor: 0.58
2015 SCImago Journal Rankings: 0.307
References

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorLauder, IJen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorMa, HKen_HK
dc.date.accessioned2012-05-29T06:10:36Z-
dc.date.available2012-05-29T06:10:36Z-
dc.date.issued1996en_HK
dc.identifier.citationEuropean Journal Of Gynaecological Oncology, 1996, v. 17 n. 6, p. 512-517en_HK
dc.identifier.issn0392-2936en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148053-
dc.description.abstractPurpose: The purpose was to evaluate the prognostic significance of serum tumour markers and other potential prognostic factors in cervical cancer. Materials and methods: Five hundred and thirty-one patients with cervical cancer were studied. The pre-treatment levels of SCC (squamous cell carcinoma antigen), TPA (tissue polypeptide antigen), CEA (carcinoembryonic antigen), CA125 and hCG (human chorionic gonadotrophin) were assayed in these patients. Possible association between raised tumour markers and potential prognostic factors and their prognostic significance were sought by univariate and multivariate Cox analysis. Results: SCC was raised in 65% of squamous cell carcinoma of the cervix and TPA was raised in 50%. Other markers were raised in less than 25%. No tumour markers were raised more than 30% in adenocarcinoma of the cervix. Raised SCC and TPA were related to advancing age, stage and grade of differentiation. Univariate analysis showed that age, stage, grade, raised SCC and TPA were significant prognostic factors on survival. Multivariate Cox analysis showed that stage was the most significant factor. Conclusion: Stage, age, grade of differentiation, raised pre-treatment levels of SCC and TPA were significant prognostic factors in cervical cancer using univariate analysis. However, only stage remains the most important independent prognostic factor in multivariate analysis. The prognostic value of these other factors in early stage disease needs further exploration.en_HK
dc.languageengen_US
dc.publisherI R O G Canada, Inc. The Journal's web site is located at http://www.irog.net/en-CA/index.aspx?CatID=4en_HK
dc.relation.ispartofEuropean Journal of Gynaecological Oncologyen_HK
dc.subjectCarcinoma of the cervixen_HK
dc.subjectPrognostic factorsen_HK
dc.subjectTumour markersen_HK
dc.subject.meshAdenocarcinoma - Diagnosis - Pathology - Physiopathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshCarcinoma, Adenosquamous - Diagnosis - Pathology - Physiopathologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Diagnosis - Pathology - Physiopathologyen_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrognosisen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshTumor Markers, Biological - Analysis - Blooden_US
dc.subject.meshUterine Cervical Neoplasms - Diagnosis - Pathology - Physiopathologyen_US
dc.titlePrognostic significance of serum tumour markers in carcinoma of the cervixen_HK
dc.typeArticleen_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8971531-
dc.identifier.scopuseid_2-s2.0-0029800867en_HK
dc.identifier.hkuros21825en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0029800867&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue6en_HK
dc.identifier.spage512en_HK
dc.identifier.epage517en_HK
dc.publisher.placeCanadaen_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridLauder, IJ=35564928000en_HK
dc.identifier.scopusauthoridWong, LC=7402092003en_HK
dc.identifier.scopusauthoridMa, HK=7403095603en_HK

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