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Article: Epstein-Barr virus is present in a wide histological spectrum of sinonasal carcinomas

TitleEpstein-Barr virus is present in a wide histological spectrum of sinonasal carcinomas
Authors
Issue Date1995
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.com
Citation
American Journal Of Surgical Pathology, 1995, v. 19 n. 9, p. 994-1001 How to Cite?
AbstractNasopharyngeal carcinoma, a common occurrence in Southern Chinese people, shows a strong association with Epstein-Barr virus (EBV); in the same population, sinonasal carcinomas are distinctly rare. Although most nasopharyngeal carcinomas are lymphoepitheliomas, sinonasal carcinomas have a wide morphological spectrum. We studied the clinicopathological features and EBV status of 29 sinonasal carcinomas from Hong Kong Chinese patients. By in situ hybridization using antisense Epstein-Barr virus early RNA (EBER) probe, seven tumors were shown to be strongly positive for the EBV RNA. They displayed a wide morphological spectrum, including one cylindric cell carcinoma, one intestinal type adenocarcinoma, four nonkeratinizing squamous cell carcinomas, and one undifferentiated carcinoma. All were from elderly subjects (mean age, 67), including six men and one woman. Three of these seven patients had complete remission after radiotherapy with a median follow-up period of 29 months. In two cases, EBV latent membrane protein-1 was expressed. Detection of the virus in a number of histological subtypes, including cylindric cell carcinoma and adenocarcinoma, suggests that EBV may play a role in the pathogenesis of a diverse spectrum of carcinomas.
Persistent Identifierhttp://hdl.handle.net/10722/148049
ISSN
2015 Impact Factor: 4.951
2015 SCImago Journal Rankings: 2.393
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_US
dc.contributor.authorYuen, STen_US
dc.contributor.authorChung, LPen_US
dc.contributor.authorKwong, WKen_US
dc.contributor.authorWong, MPen_US
dc.contributor.authorChan, SYen_US
dc.date.accessioned2012-05-29T06:10:35Z-
dc.date.available2012-05-29T06:10:35Z-
dc.date.issued1995en_US
dc.identifier.citationAmerican Journal Of Surgical Pathology, 1995, v. 19 n. 9, p. 994-1001en_US
dc.identifier.issn0147-5185en_US
dc.identifier.urihttp://hdl.handle.net/10722/148049-
dc.description.abstractNasopharyngeal carcinoma, a common occurrence in Southern Chinese people, shows a strong association with Epstein-Barr virus (EBV); in the same population, sinonasal carcinomas are distinctly rare. Although most nasopharyngeal carcinomas are lymphoepitheliomas, sinonasal carcinomas have a wide morphological spectrum. We studied the clinicopathological features and EBV status of 29 sinonasal carcinomas from Hong Kong Chinese patients. By in situ hybridization using antisense Epstein-Barr virus early RNA (EBER) probe, seven tumors were shown to be strongly positive for the EBV RNA. They displayed a wide morphological spectrum, including one cylindric cell carcinoma, one intestinal type adenocarcinoma, four nonkeratinizing squamous cell carcinomas, and one undifferentiated carcinoma. All were from elderly subjects (mean age, 67), including six men and one woman. Three of these seven patients had complete remission after radiotherapy with a median follow-up period of 29 months. In two cases, EBV latent membrane protein-1 was expressed. Detection of the virus in a number of histological subtypes, including cylindric cell carcinoma and adenocarcinoma, suggests that EBV may play a role in the pathogenesis of a diverse spectrum of carcinomas.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ajsp.comen_US
dc.relation.ispartofAmerican Journal of Surgical Pathologyen_US
dc.rightsAmerican Journal of Surgical Pathology. Copyright © Lippincott Williams & Wilkins.-
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma - Metabolism - Pathology - Virologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHerpesvirus 4, Human - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNose Neoplasms - Metabolism - Pathology - Virologyen_US
dc.subject.meshParanasal Sinus Neoplasms - Metabolism - Pathology - Virologyen_US
dc.subject.meshRna, Viral - Analysisen_US
dc.titleEpstein-Barr virus is present in a wide histological spectrum of sinonasal carcinomasen_US
dc.typeArticleen_US
dc.identifier.emailSuet Yi Leung:suetyi@hkucc.hku.hken_US
dc.identifier.authoritySuet Yi Leung=rp00359en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7661287-
dc.identifier.scopuseid_2-s2.0-0029127211en_US
dc.identifier.hkuros8761-
dc.identifier.volume19en_US
dc.identifier.issue9en_US
dc.identifier.spage994en_US
dc.identifier.epage1001en_US
dc.identifier.isiWOS:A1995RQ38400002-
dc.publisher.placeUnited Statesen_US

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