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Article: Better survival in female patients with hepatocellular carcinoma: Possible causes from a pathologic approach

TitleBetter survival in female patients with hepatocellular carcinoma: Possible causes from a pathologic approach
Authors
KeywordsHepatocellular carcinoma
Survival rates
Tumor encapsulation
Tumor invasiveness
Women
Issue Date1995
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1995, v. 75 n. 1, p. 18-22 How to Cite?
AbstractBackground. Hepatocellular carcinoma is notably more prevalent in men than in women. Methods. To examine the sex-related characteristics of patients with primary hepatocellular carcinoma, 35 women were compared with 243 men, both groups having undergone surgical resection of the tumor. Results. Women had a lower incidence of tumor recurrence, with median disease free survival of 19.5 months compared with 4.5 months for men (P < 0.001). Women also had more favorable actuarial survival than men [36.5 months for women compared with 12.4 months for men (P = 0.002)]. Women had a significantly higher incidence (80%) of tumor encapsulation than men (45%) (P < 0.001). Furthermore, the tumors in women were frequently less invasive in terms of lower incidence of tumor microsatellites, liver invasion, and positive histologic margin. Tumor microsatellite formation was present with 16% of tumors in women, compared with 60% for men (P < 0.0001). Liver invasion was found in 37% of tumors in women and 61% in men (P = 0.03). Only 6% of tumors in women had a positive histologic margin, compared to 24% in men (P = 0.04). There was no statistical significance in the incidence of cirrhosis in the nontumorous liver, hepatitis B surface antigen positivity, mean age, or tumor size, between women and men. Conclusions. Women who had hepatocellular carcinoma and hepatic resection had better survival rates and a lower rate of tumor recurrence than male patients. The better prognosis in women with hepatocellular carcinoma appeared to be related to the pathobiologic characteristics of the tumor (i.e., frequent encapsulation and lower tumor invasiveness).
Persistent Identifierhttp://hdl.handle.net/10722/148038
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_US
dc.contributor.authorNg, MMTen_US
dc.contributor.authorLai, ECSen_US
dc.contributor.authorFan, STen_US
dc.date.accessioned2012-05-29T06:10:31Z-
dc.date.available2012-05-29T06:10:31Z-
dc.date.issued1995en_US
dc.identifier.citationCancer, 1995, v. 75 n. 1, p. 18-22en_US
dc.identifier.issn0008-543Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/148038-
dc.description.abstractBackground. Hepatocellular carcinoma is notably more prevalent in men than in women. Methods. To examine the sex-related characteristics of patients with primary hepatocellular carcinoma, 35 women were compared with 243 men, both groups having undergone surgical resection of the tumor. Results. Women had a lower incidence of tumor recurrence, with median disease free survival of 19.5 months compared with 4.5 months for men (P < 0.001). Women also had more favorable actuarial survival than men [36.5 months for women compared with 12.4 months for men (P = 0.002)]. Women had a significantly higher incidence (80%) of tumor encapsulation than men (45%) (P < 0.001). Furthermore, the tumors in women were frequently less invasive in terms of lower incidence of tumor microsatellites, liver invasion, and positive histologic margin. Tumor microsatellite formation was present with 16% of tumors in women, compared with 60% for men (P < 0.0001). Liver invasion was found in 37% of tumors in women and 61% in men (P = 0.03). Only 6% of tumors in women had a positive histologic margin, compared to 24% in men (P = 0.04). There was no statistical significance in the incidence of cirrhosis in the nontumorous liver, hepatitis B surface antigen positivity, mean age, or tumor size, between women and men. Conclusions. Women who had hepatocellular carcinoma and hepatic resection had better survival rates and a lower rate of tumor recurrence than male patients. The better prognosis in women with hepatocellular carcinoma appeared to be related to the pathobiologic characteristics of the tumor (i.e., frequent encapsulation and lower tumor invasiveness).en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_US
dc.relation.ispartofCanceren_US
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.-
dc.subjectHepatocellular carcinoma-
dc.subjectSurvival rates-
dc.subjectTumor encapsulation-
dc.subjectTumor invasiveness-
dc.subjectWomen-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular - Mortality - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Cirrhosis - Complicationsen_US
dc.subject.meshLiver Neoplasms - Mortality - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSex Characteristicsen_US
dc.subject.meshSurvival Analysisen_US
dc.titleBetter survival in female patients with hepatocellular carcinoma: Possible causes from a pathologic approachen_US
dc.typeArticleen_US
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_US
dc.identifier.emailFan, ST:stfan@hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19950101)75:1<18::AID-CNCR2820750105>3.0.CO;2-#en_US
dc.identifier.pmid7804971-
dc.identifier.scopuseid_2-s2.0-0028872703en_US
dc.identifier.hkuros10588-
dc.identifier.volume75en_US
dc.identifier.issue1en_US
dc.identifier.spage18en_US
dc.identifier.epage22en_US
dc.identifier.isiWOS:A1995QA65700004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNg, IOL=7102753722-
dc.identifier.scopusauthoridNg, MMT=7202076310-
dc.identifier.scopusauthoridLai, ECS=55187352300-
dc.identifier.scopusauthoridFan, ST=7402678224-

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