File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prognostic significance of pathologic features of hepatocellular carcinoma: a multivariate analysis of 278 patients

TitlePrognostic significance of pathologic features of hepatocellular carcinoma: a multivariate analysis of 278 patients
Authors
Keywordshepatocellular carcinoma
pathologic features
prognosis
tumor recurrence
Issue Date1995
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1995, v. 76 n. 12, p. 2443-2448 How to Cite?
AbstractBackground. In patients with hepatocellular carcinoma, surgical resection may offer a chance of cure. However, tumor recurrence is not infrequent after resection. Methods. To identify the pathologic factors that are of prognostic significance and predictive value in tumor recurrence, the authors studied 278 patients (243 men, 35 women) who had hepatectomy for hepatocellular carcinoma. Disease free and actuarial survival were correlated with 20 pathologic parameters of the resected specimens using multivariate analysis. Results. The median follow-up period was 23.6 months. The overall disease free survival rates at 1, 3 and 5 years were 42%, 23%, and 17%, respectively, and the overall actuarial survival rates for the corresponding time periods were 70%, 39%, and 28%, respectively. The results indicated that tumor encapsulation (P = 0.004) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors related to tumor recurrence. Negative resection margins (P = 0.001) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors correlated with survival. Conclusions. From this analysis, it was determined that detailed histologic examination of resected specimens of hepatocellular carcinoma is important in assessing long term prognosis and stratification of patients for treatment.
Persistent Identifierhttp://hdl.handle.net/10722/148034
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorNg, MMTen_HK
dc.contributor.authorSo, MKPen_HK
dc.date.accessioned2012-05-29T06:10:30Z-
dc.date.available2012-05-29T06:10:30Z-
dc.date.issued1995en_HK
dc.identifier.citationCancer, 1995, v. 76 n. 12, p. 2443-2448en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/148034-
dc.description.abstractBackground. In patients with hepatocellular carcinoma, surgical resection may offer a chance of cure. However, tumor recurrence is not infrequent after resection. Methods. To identify the pathologic factors that are of prognostic significance and predictive value in tumor recurrence, the authors studied 278 patients (243 men, 35 women) who had hepatectomy for hepatocellular carcinoma. Disease free and actuarial survival were correlated with 20 pathologic parameters of the resected specimens using multivariate analysis. Results. The median follow-up period was 23.6 months. The overall disease free survival rates at 1, 3 and 5 years were 42%, 23%, and 17%, respectively, and the overall actuarial survival rates for the corresponding time periods were 70%, 39%, and 28%, respectively. The results indicated that tumor encapsulation (P = 0.004) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors related to tumor recurrence. Negative resection margins (P = 0.001) and heavy intratumor inflammatory infiltrates (P = 0.003) were independent favorable factors correlated with survival. Conclusions. From this analysis, it was determined that detailed histologic examination of resected specimens of hepatocellular carcinoma is important in assessing long term prognosis and stratification of patients for treatment.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.-
dc.subjecthepatocellular carcinomaen_HK
dc.subjectpathologic featuresen_HK
dc.subjectprognosisen_HK
dc.subjecttumor recurrenceen_HK
dc.subject.meshActuarial Analysisen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular - Pathology - Surgeryen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatectomyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Pathology - Surgeryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshTreatment Outcomeen_US
dc.titlePrognostic significance of pathologic features of hepatocellular carcinoma: a multivariate analysis of 278 patientsen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailLai, ECS: ecslai@HKUCC.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/1097-0142(19951215)76:12<2443::AID-CNCR2820761207>3.0.CO;2-Fen_HK
dc.identifier.pmid8625069-
dc.identifier.scopuseid_2-s2.0-0028845813en_HK
dc.identifier.hkuros9747-
dc.identifier.hkuros10590-
dc.identifier.volume76en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2443en_HK
dc.identifier.epage2448en_HK
dc.identifier.isiWOS:A1995TJ10600006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridLai, ECS=55187430500en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridNg, MMT=7202076310en_HK
dc.identifier.scopusauthoridSo, MKP=36719004700en_HK
dc.customcontrol.immutablesml 130703-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats