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Article: Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas

TitleExpression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas
Authors
Cheung, ANYSrivastava, GChung, LPNgan, HYSMan, TKLiu, YTChen, WZCollins, RJWong, LCMa, HK
Issue Date1994
PublisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com
Citation
Journal Of Reproductive Medicine For The Obstetrician And Gynecologist, 1994, v. 39 n. 3, p. 223-227 How to Cite?
AbstractIn this study we compared the expression of p53 in six early placentas and eight hydatidiform moles using Northern blotting. A higher expression of p53 in hydatidiform moles as compared to normal placentas of comparable gestational age was observed. Immunohistochemical studies did not detect mutant protein of p53 in the hydatidiform moles. DNA sequencing was performed on four of the hydatidiform moles with increased expression of p53, but no mutations could be detected. The possible role of p53 in the pathogenesis of hydatidiform mole is discussed.
Persistent Identifierhttp://hdl.handle.net/10722/148021
ISSN
0024-7758
2021 Impact Factor: 0.218
2020 SCImago Journal Rankings: 0.132
ISI Accession Number ID
WOS:A1994NC78300014

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorSrivastava, Gen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorMan, TKen_HK
dc.contributor.authorLiu, YTen_HK
dc.contributor.authorChen, WZen_HK
dc.contributor.authorCollins, RJen_HK
dc.contributor.authorWong, LCen_HK
dc.contributor.authorMa, HKen_HK
dc.date.accessioned2012-05-29T06:10:25Z-
dc.date.available2012-05-29T06:10:25Z-
dc.date.issued1994en_HK
dc.identifier.citationJournal Of Reproductive Medicine For The Obstetrician And Gynecologist, 1994, v. 39 n. 3, p. 223-227en_HK
dc.identifier.issn0024-7758en_HK
dc.identifier.urihttp://hdl.handle.net/10722/148021-
dc.description.abstractIn this study we compared the expression of p53 in six early placentas and eight hydatidiform moles using Northern blotting. A higher expression of p53 in hydatidiform moles as compared to normal placentas of comparable gestational age was observed. Immunohistochemical studies did not detect mutant protein of p53 in the hydatidiform moles. DNA sequencing was performed on four of the hydatidiform moles with increased expression of p53, but no mutations could be detected. The possible role of p53 in the pathogenesis of hydatidiform mole is discussed.en_HK
dc.languageengen_US
dc.publisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.comen_HK
dc.relation.ispartofJournal of Reproductive Medicine for the Obstetrician and Gynecologisten_HK
dc.subject.meshBase Sequenceen_US
dc.subject.meshBlotting, Northernen_US
dc.subject.meshDna, Neoplasmen_US
dc.subject.meshEvaluation Studies As Topicen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Expression Regulation, Neoplastic - Geneticsen_US
dc.subject.meshGenes, P53 - Geneticsen_US
dc.subject.meshGestational Ageen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole - Genetics - Pathologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPlacenta - Anatomy & Histologyen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshTranscription, Geneticen_US
dc.subject.meshUterine Neoplasms - Genetics - Pathologyen_US
dc.titleExpression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentasen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailSrivastava, G: sgopesh@hkucc.hku.hken_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailCollins, RJ: rcollins@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authoritySrivastava, G=rp00365en_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCollins, RJ=rp00251en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8035377en_HK
dc.identifier.scopuseid_2-s2.0-0028279895en_HK
dc.identifier.hkuros5243en_US
dc.identifier.volume39en_HK
dc.identifier.issue3en_HK
dc.identifier.spage223en_HK
dc.identifier.epage227en_HK
dc.identifier.isiWOS:A1994NC78300014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridSrivastava, G=7202242238en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridMan, TK=36865477200en_HK
dc.identifier.scopusauthoridLiu, YT=26643293600en_HK
dc.identifier.scopusauthoridChen, WZ=7409644701en_HK
dc.identifier.scopusauthoridCollins, RJ=7403350455en_HK
dc.identifier.scopusauthoridWong, LC=7402092003en_HK
dc.identifier.scopusauthoridMa, HK=7403095603en_HK
dc.identifier.issnl0024-7758-

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