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Article: CEA tissue staining in colorectal cancer patients correlation with plasma CEA, histology and staging

TitleCEA tissue staining in colorectal cancer patients correlation with plasma CEA, histology and staging
Authors
Issue Date1993
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.asp
Citation
Pathology, 1993, v. 25 n. 3, p. 219-222 How to Cite?
AbstractTo study the expression of tissue carcinoembryonic antigen (CEA) by immunoperoxidase staining in colorectal adenocarcinomas and its relation with preoperative serum CEA and clinicopathological parameters, we studied 85 unselected patients who underwent resective surgery for colorectal adenocarcinomas and were followed up for a mean of 66 mths. All tumors except 2 showed positive staining for CEA. The staining pattern was classifiable into 4 types: apical, cytoplasmic, basolateral and stromal, according to the predominant sites of staining. We found a significant positive correlation between tissue CEA staining pattern and preoperative plasma CEA. Plasma CEA levels were higher when tumor cell staining extended to basolateral regions of the cells and into stromal tissues rather than restricted to apical and cytoplasmic regions (p = 0.012). Furthermore, tissue CEA staining also correlated positively with vascular invasion by tumor cells (p = 0.046), with basolateral and stromal types associated with more frequent vascular invasion than apical and cytoplasmic types. This was in contrast to the preoperative CEA which did not correlate with vascular permeation. We speculate that tissue CEA staining is useful in indicating possible vascular invasion even at early stage whereas vascular invasion by a larger tumor bulk or even tumor metastases may be necessary to produce an increased plasma CEA level that is detectable. On the other hand, preoperative plasma CEA had a strong, positive relationship with tumor stage and mortality (p < 0.001 for both). Preoperative CEA was higher in tumors showing moderate and poor differentiation, although it did not reach statistical significance (p = 0.068), whereas tissue CEA staining had no correlation with tumor differention. Although tissue CEA staining patterns appear useful in explaining some pathophysiological events, it offers little additional information to plasma CEA En management of patients with colorectal carcinoma.
Persistent Identifierhttp://hdl.handle.net/10722/147995
ISSN
2015 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.049
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_US
dc.contributor.authorHo, Jen_US
dc.contributor.authorPritchett, CJen_US
dc.contributor.authorChan, EYTen_US
dc.contributor.authorHo, FCSen_US
dc.date.accessioned2012-05-29T06:10:17Z-
dc.date.available2012-05-29T06:10:17Z-
dc.date.issued1993en_US
dc.identifier.citationPathology, 1993, v. 25 n. 3, p. 219-222en_US
dc.identifier.issn0031-3025en_US
dc.identifier.urihttp://hdl.handle.net/10722/147995-
dc.description.abstractTo study the expression of tissue carcinoembryonic antigen (CEA) by immunoperoxidase staining in colorectal adenocarcinomas and its relation with preoperative serum CEA and clinicopathological parameters, we studied 85 unselected patients who underwent resective surgery for colorectal adenocarcinomas and were followed up for a mean of 66 mths. All tumors except 2 showed positive staining for CEA. The staining pattern was classifiable into 4 types: apical, cytoplasmic, basolateral and stromal, according to the predominant sites of staining. We found a significant positive correlation between tissue CEA staining pattern and preoperative plasma CEA. Plasma CEA levels were higher when tumor cell staining extended to basolateral regions of the cells and into stromal tissues rather than restricted to apical and cytoplasmic regions (p = 0.012). Furthermore, tissue CEA staining also correlated positively with vascular invasion by tumor cells (p = 0.046), with basolateral and stromal types associated with more frequent vascular invasion than apical and cytoplasmic types. This was in contrast to the preoperative CEA which did not correlate with vascular permeation. We speculate that tissue CEA staining is useful in indicating possible vascular invasion even at early stage whereas vascular invasion by a larger tumor bulk or even tumor metastases may be necessary to produce an increased plasma CEA level that is detectable. On the other hand, preoperative plasma CEA had a strong, positive relationship with tumor stage and mortality (p < 0.001 for both). Preoperative CEA was higher in tumors showing moderate and poor differentiation, although it did not reach statistical significance (p = 0.068), whereas tissue CEA staining had no correlation with tumor differention. Although tissue CEA staining patterns appear useful in explaining some pathophysiological events, it offers little additional information to plasma CEA En management of patients with colorectal carcinoma.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00313025.aspen_US
dc.relation.ispartofPathologyen_US
dc.subject.meshAdenocarcinoma - Chemistry - Mortality - Pathologyen_US
dc.subject.meshCarcinoembryonic Antigen - Analysis - Blooden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshColorectal Neoplasms - Chemistry - Mortality - Pathologyen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshSurvival Rateen_US
dc.titleCEA tissue staining in colorectal cancer patients correlation with plasma CEA, histology and stagingen_US
dc.typeArticleen_US
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8265235-
dc.identifier.scopuseid_2-s2.0-0027747030en_US
dc.identifier.volume25en_US
dc.identifier.issue3en_US
dc.identifier.spage219en_US
dc.identifier.epage222en_US
dc.identifier.isiWOS:A1993MW44900001-
dc.publisher.placeUnited Kingdomen_US

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