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Article: The pathological basis of resection margin for hepatocellular carcinoma

TitleThe pathological basis of resection margin for hepatocellular carcinoma
Authors
Issue Date1993
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/
Citation
World Journal Of Surgery, 1993, v. 17 n. 6, p. 786-791 How to Cite?
AbstractAt the time of hepatectomy for primary hepatocellular carcinoma (HCC), the necessary amount of surrounding nontumorous liver to be sacrificed, or the resection margin, which will ensure a complete histologic disease clearance is uncertain. Twenty-three resected liver specimens were studied by serial section followed by histological examination prospectively. All histologic diseases identified were assumed to spread radially in all directions from a unicentric lesion. Histologic disease from capsular and liver invasion was found confined to the immediate surrounding liver parenchyma. Eleven of the 14 large (≥5 cm) tumors and all six small (<5 cm) HCCs had either microsatellites and/or histologic venous permeation found beyond 1 cm from the lesion. A large tumor, multinodular lesions, macroscopic venous thrombi, liver invasion, and nonencapsulation were associated with an extensive spread of histologic disease. In the presence of either microsatellites or histologic venous permeation, no distance could ensure a complete disease clearance.
Persistent Identifierhttp://hdl.handle.net/10722/147993
ISSN
2015 Impact Factor: 2.523
2015 SCImago Journal Rankings: 1.375

 

DC FieldValueLanguage
dc.contributor.authorLai, ECSen_US
dc.contributor.authorYou, KTen_US
dc.contributor.authorNg, IOLen_US
dc.contributor.authorShek, TWHen_US
dc.contributor.authorBraasch, JWen_US
dc.date.accessioned2012-05-29T06:10:16Z-
dc.date.available2012-05-29T06:10:16Z-
dc.date.issued1993en_US
dc.identifier.citationWorld Journal Of Surgery, 1993, v. 17 n. 6, p. 786-791en_US
dc.identifier.issn0364-2313en_US
dc.identifier.urihttp://hdl.handle.net/10722/147993-
dc.description.abstractAt the time of hepatectomy for primary hepatocellular carcinoma (HCC), the necessary amount of surrounding nontumorous liver to be sacrificed, or the resection margin, which will ensure a complete histologic disease clearance is uncertain. Twenty-three resected liver specimens were studied by serial section followed by histological examination prospectively. All histologic diseases identified were assumed to spread radially in all directions from a unicentric lesion. Histologic disease from capsular and liver invasion was found confined to the immediate surrounding liver parenchyma. Eleven of the 14 large (≥5 cm) tumors and all six small (<5 cm) HCCs had either microsatellites and/or histologic venous permeation found beyond 1 cm from the lesion. A large tumor, multinodular lesions, macroscopic venous thrombi, liver invasion, and nonencapsulation were associated with an extensive spread of histologic disease. In the presence of either microsatellites or histologic venous permeation, no distance could ensure a complete disease clearance.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00268/en_US
dc.relation.ispartofWorld Journal of Surgeryen_US
dc.subject.meshCarcinoma, Hepatocellular - Pathology - Surgeryen_US
dc.subject.meshHepatectomy - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Pathology - Surgeryen_US
dc.subject.meshProspective Studiesen_US
dc.titleThe pathological basis of resection margin for hepatocellular carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF01659097en_US
dc.identifier.pmid8109119-
dc.identifier.scopuseid_2-s2.0-0027730076en_US
dc.identifier.volume17en_US
dc.identifier.issue6en_US
dc.identifier.spage786en_US
dc.identifier.epage791en_US
dc.publisher.placeUnited Statesen_US

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