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Article: Resolution of membranoproliferative glomerulonephritis complicating angiofollicular lymph node hyperplasia (Castleman's Disease)

TitleResolution of membranoproliferative glomerulonephritis complicating angiofollicular lymph node hyperplasia (Castleman's Disease)
Authors
KeywordsAngiofollicular lymph node hyperplasia
Castleman's disease
Membranoproliferative glomerulonephritis
Issue Date1993
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEF
Citation
Nephron, 1993, v. 65 n. 4, p. 628-632 How to Cite?
AbstractA novel renal complication was reported in a patient with angiofollicular lymph node hyperplasia (Castleman's Disease), who developed acute renal failure due to membranoproliferative glomerulonephritis. Renal biopsy showed marked mesangial hyperplasia, basement membrane thickening with subendothelial electron-dense deposits, interstitial plasma cell infiltration, and glomerular deposition of IgM and complement components. A resolution of systemic manifestations and an improvement in renal function followed prednisolone and azathioprine therapy. Disease relapse, with increasing proteinuria and the development of factor 8 inhibitor, occurred 3 months later. Sustained remission was achieved with prednisolone and cyclophosphamide therapy, which were given for 42 and 12 months, respectively. Renal biopsy during remission showed significant resolution of the mesangial hyperplasia and disappearance of interstitial plasmacytic infiltration as well as subendothelial electron-dense deposits.
Persistent Identifierhttp://hdl.handle.net/10722/147969
ISSN
2004 Impact Factor: 1.462
2006 SCImago Journal Rankings: 0.715
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, TMen_HK
dc.contributor.authorCheng, IKPen_HK
dc.contributor.authorWong, KLen_HK
dc.contributor.authorChan, KWen_HK
dc.date.accessioned2012-05-29T06:10:09Z-
dc.date.available2012-05-29T06:10:09Z-
dc.date.issued1993en_HK
dc.identifier.citationNephron, 1993, v. 65 n. 4, p. 628-632en_HK
dc.identifier.issn0028-2766en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147969-
dc.description.abstractA novel renal complication was reported in a patient with angiofollicular lymph node hyperplasia (Castleman's Disease), who developed acute renal failure due to membranoproliferative glomerulonephritis. Renal biopsy showed marked mesangial hyperplasia, basement membrane thickening with subendothelial electron-dense deposits, interstitial plasma cell infiltration, and glomerular deposition of IgM and complement components. A resolution of systemic manifestations and an improvement in renal function followed prednisolone and azathioprine therapy. Disease relapse, with increasing proteinuria and the development of factor 8 inhibitor, occurred 3 months later. Sustained remission was achieved with prednisolone and cyclophosphamide therapy, which were given for 42 and 12 months, respectively. Renal biopsy during remission showed significant resolution of the mesangial hyperplasia and disappearance of interstitial plasmacytic infiltration as well as subendothelial electron-dense deposits.en_HK
dc.languageengen_US
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEFen_HK
dc.relation.ispartofNephronen_HK
dc.subjectAngiofollicular lymph node hyperplasiaen_HK
dc.subjectCastleman's diseaseen_HK
dc.subjectMembranoproliferative glomerulonephritisen_HK
dc.subject.meshAdulten_US
dc.subject.meshAzathioprine - Therapeutic Useen_US
dc.subject.meshBiopsyen_US
dc.subject.meshComplement System Proteins - Analysisen_US
dc.subject.meshCyclophosphamide - Therapeutic Useen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGiant Lymph Node Hyperplasia - Complications - Drug Therapy - Pathologyen_US
dc.subject.meshGlomerulonephritis, Membranoproliferative - Complications - Drug Therapy - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin M - Analysisen_US
dc.subject.meshKidney Failure, Chronic - Etiologyen_US
dc.subject.meshKidney Glomerulus - Chemistry - Pathologyen_US
dc.subject.meshPrednisolone - Therapeutic Useen_US
dc.subject.meshPrognosisen_US
dc.titleResolution of membranoproliferative glomerulonephritis complicating angiofollicular lymph node hyperplasia (Castleman's Disease)en_HK
dc.typeArticleen_HK
dc.identifier.emailChan, TM:dtmchan@hku.hken_HK
dc.identifier.emailChan, KW:hrmtckw@hku.hken_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityChan, KW=rp00330en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8302422-
dc.identifier.scopuseid_2-s2.0-0027377785en_HK
dc.identifier.volume65en_HK
dc.identifier.issue4en_HK
dc.identifier.spage628en_HK
dc.identifier.epage632en_HK
dc.identifier.isiWOS:A1993MJ67200022-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridCheng, IKP=7102537483en_HK
dc.identifier.scopusauthoridWong, KL=7404759833en_HK
dc.identifier.scopusauthoridChan, KW=16444133100en_HK

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