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Article: The significance of proliferating cell nuclear antigen in human trophoblastic disease: An immunohistochemical study

TitleThe significance of proliferating cell nuclear antigen in human trophoblastic disease: An immunohistochemical study
Authors
KeywordsProliferating cell nuclear antigen
Trophoblastic disease
Issue Date1993
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1993, v. 22 n. 6, p. 565-568 How to Cite?
AbstractThe expression of proliferating cell nuclear antigen (PCNA) in human trophoblastic disease was assessed immunohistochemically in tissue from 29 spontaneous abortions, 33 partial moles, 40 complete moles and 23 choriocarcinomas using the monoclonal antibody PC10. PCNA immunoreactivity occurred predominantly in the cytotrophoblasts in each of the four types of tissue. Quantitative analysis showed that the choriocarcinoma group gave a statistically significant higher PCNA index than the other three. There was no significant difference between the groups of spontaneous abortion, partial or complete mole. Sixteen of the 73 patients with partial and complete moles developed persistent gestational trophoblastic disease and there was no significant difference between the patients requiring chemotherapy and those who did not. We conclude that choriocarcinoma has a significantly higher PCNA proliferative index whilst hydatidiform moles cannot be distinguished from abortions by such analysis. The PCNA index does not appear to be useful in predicting the progression of molar pregnancies to persistent trophoblastic diseases.
Persistent Identifierhttp://hdl.handle.net/10722/147961
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorChen, WZen_HK
dc.contributor.authorLoke, SLen_HK
dc.contributor.authorCollins, RJen_HK
dc.date.accessioned2012-05-29T06:10:07Z-
dc.date.available2012-05-29T06:10:07Z-
dc.date.issued1993en_HK
dc.identifier.citationHistopathology, 1993, v. 22 n. 6, p. 565-568en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147961-
dc.description.abstractThe expression of proliferating cell nuclear antigen (PCNA) in human trophoblastic disease was assessed immunohistochemically in tissue from 29 spontaneous abortions, 33 partial moles, 40 complete moles and 23 choriocarcinomas using the monoclonal antibody PC10. PCNA immunoreactivity occurred predominantly in the cytotrophoblasts in each of the four types of tissue. Quantitative analysis showed that the choriocarcinoma group gave a statistically significant higher PCNA index than the other three. There was no significant difference between the groups of spontaneous abortion, partial or complete mole. Sixteen of the 73 patients with partial and complete moles developed persistent gestational trophoblastic disease and there was no significant difference between the patients requiring chemotherapy and those who did not. We conclude that choriocarcinoma has a significantly higher PCNA proliferative index whilst hydatidiform moles cannot be distinguished from abortions by such analysis. The PCNA index does not appear to be useful in predicting the progression of molar pregnancies to persistent trophoblastic diseases.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.subjectProliferating cell nuclear antigenen_HK
dc.subjectTrophoblastic diseaseen_HK
dc.subject.meshAbortion, Spontaneous - Immunologyen_US
dc.subject.meshAntigens, Neoplasm - Metabolismen_US
dc.subject.meshChoriocarcinoma - Diagnosis - Immunologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydatidiform Mole - Diagnosis - Immunologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNuclear Proteins - Immunology - Metabolismen_US
dc.subject.meshPregnancyen_US
dc.subject.meshProliferating Cell Nuclear Antigenen_US
dc.subject.meshTrophoblastic Neoplasms - Diagnosis - Immunologyen_US
dc.subject.meshUterine Neoplasms - Diagnosis - Immunologyen_US
dc.titleThe significance of proliferating cell nuclear antigen in human trophoblastic disease: An immunohistochemical studyen_HK
dc.typeArticleen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailCollins, RJ:rcollins@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityCollins, RJ=rp00251en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8102616-
dc.identifier.scopuseid_2-s2.0-0027286703en_HK
dc.identifier.volume22en_HK
dc.identifier.issue6en_HK
dc.identifier.spage565en_HK
dc.identifier.epage568en_HK
dc.identifier.isiWOS:A1993LH54100007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridChen, WZ=7409644701en_HK
dc.identifier.scopusauthoridLoke, SL=7006559512en_HK
dc.identifier.scopusauthoridCollins, RJ=7403350455en_HK

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