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Article: Pattern of cerebral atherosclerosis in Hong Kong Chinese: Severity in intracranial and extracranial vessels

TitlePattern of cerebral atherosclerosis in Hong Kong Chinese: Severity in intracranial and extracranial vessels
Authors
Issue Date1993
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org
Citation
Stroke, 1993, v. 24 n. 6, p. 779-786 How to Cite?
AbstractBackground and Purpose: The clinical pattern of stroke and the angiographic distribution of cerebral atherosclerosis in Chinese are different from those in Caucasians. Pathological data from autopsy studies are lacking. Methods: The intracranial and extracranial arteries supplying the brains of 114 consecutive Chinese patients undergoing autopsy in a regional general hospital were examined by computer-assisted morphometric analysis under a microscope as well as by macroscopic grading for atherosclerotic narrowing. The severity was correlated with various atherosclerosis-related factors. Results: Atherosclerosis of the intracranial cerebral vessels was more severe than that of the extracranial vessels. The distal branches of the intracranial vessels were also commonly involved. Hypertension and diabetes mellitus were identified as factors associated only with intracranial atherosclerosis (p<0.001), whereas ischemic heart disease was associated with atherosclerosis in both the intracranial (p<0.001) and extracranial (p=0.012) vessels. Smoking was associated with narrowing of the extracranial vessels only (p=0.0054). Conclusions: Compared with figures from Caucasian and Japanese populations, the extent of intracranial atherosclerosis is much more severe in Hong Kong Chinese, whereas atherosclerotic narrowing of the extracranial carotid artery is less severe in Hong Kong Chinese than in Caucasians.
Persistent Identifierhttp://hdl.handle.net/10722/147957
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSuet Yi Leungen_US
dc.contributor.authorNg, THKen_US
dc.contributor.authorSiu Tsan Yuenen_US
dc.contributor.authorLauder, IJen_US
dc.contributor.authorHo, FCSen_US
dc.date.accessioned2012-05-29T06:10:06Z-
dc.date.available2012-05-29T06:10:06Z-
dc.date.issued1993en_US
dc.identifier.citationStroke, 1993, v. 24 n. 6, p. 779-786en_US
dc.identifier.issn0039-2499en_US
dc.identifier.urihttp://hdl.handle.net/10722/147957-
dc.description.abstractBackground and Purpose: The clinical pattern of stroke and the angiographic distribution of cerebral atherosclerosis in Chinese are different from those in Caucasians. Pathological data from autopsy studies are lacking. Methods: The intracranial and extracranial arteries supplying the brains of 114 consecutive Chinese patients undergoing autopsy in a regional general hospital were examined by computer-assisted morphometric analysis under a microscope as well as by macroscopic grading for atherosclerotic narrowing. The severity was correlated with various atherosclerosis-related factors. Results: Atherosclerosis of the intracranial cerebral vessels was more severe than that of the extracranial vessels. The distal branches of the intracranial vessels were also commonly involved. Hypertension and diabetes mellitus were identified as factors associated only with intracranial atherosclerosis (p<0.001), whereas ischemic heart disease was associated with atherosclerosis in both the intracranial (p<0.001) and extracranial (p=0.012) vessels. Smoking was associated with narrowing of the extracranial vessels only (p=0.0054). Conclusions: Compared with figures from Caucasian and Japanese populations, the extent of intracranial atherosclerosis is much more severe in Hong Kong Chinese, whereas atherosclerotic narrowing of the extracranial carotid artery is less severe in Hong Kong Chinese than in Caucasians.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.orgen_US
dc.relation.ispartofStrokeen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAgingen_US
dc.subject.meshArteriosclerosis - Complications - Epidemiology - Pathologyen_US
dc.subject.meshAutopsyen_US
dc.subject.meshCarotid Arteries - Pathologyen_US
dc.subject.meshCerebral Arteries - Pathologyen_US
dc.subject.meshCerebrovascular Disorders - Epidemiology - Etiology - Pathologyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshDiabetes Complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Complicationsen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia - Complicationsen_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.titlePattern of cerebral atherosclerosis in Hong Kong Chinese: Severity in intracranial and extracranial vesselsen_US
dc.typeArticleen_US
dc.identifier.emailSuet Yi Leung:suetyi@hkucc.hku.hken_US
dc.identifier.authoritySuet Yi Leung=rp00359en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid8506547-
dc.identifier.scopuseid_2-s2.0-0027238069en_US
dc.identifier.volume24en_US
dc.identifier.issue6en_US
dc.identifier.spage779en_US
dc.identifier.epage786en_US
dc.identifier.isiWOS:A1993LE37400001-
dc.publisher.placeUnited Statesen_US

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