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Article: Hepatocellular ballooning after liver transplantation: A light and electronmicroscopic study with clinicopathological correlation

TitleHepatocellular ballooning after liver transplantation: A light and electronmicroscopic study with clinicopathological correlation
Authors
Issue Date1991
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1991, v. 18 n. 4, p. 323-330 How to Cite?
AbstractThe histopathological features of orthotopic liver grafts were studied in 107 serial specimens from 25 patients, to assess the prevalence, possible pathogenesis and prognostic implications of hepatocellular ballooning. Ballooned hepatocytes were found in 46 (54%) of 85 biopsies taken five or more days after transplantation from 16 patients. They were not found in any of the protocol biopsies taken at the time of the operation. Ballooning usually appeared in the second week after transplantation, and in most patients persisted to the time of the latest biopsy studied. The affected cells were always found in acinar zone 3, and sometimes also in other zones. Forty-four of the 46 biopsies with ballooning were taken during a period of clinical and biochemical cholestasis. In 13 of the 16 patients the degree of ballooning paralleled the severity of the cholestasis. Electronmicroscopy of affected hepatocytes showed conspicuous dilatation of the cisternae of the rough endoplasmic reticulum rather than the classical features of cholestasis. It was therefore concluded that ballooning was associated with but not directly caused by bile retention. There was no obvious association between ballooning and cellular rejection, sepsis, immnnosuppressive therapy or parenteral nutrition. The most severe early ballooning was associated with serum transaminase levels over 1000 IU/l within 48 h of transplantation, suggesting that ischaemia was one of the pathogenetic factors. Hepatocellular ballooning did not in itself appear to have sinister short-term prognostic implications.
Persistent Identifierhttp://hdl.handle.net/10722/147881
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_US
dc.contributor.authorBurroughs, AKen_US
dc.contributor.authorRolles, Ken_US
dc.contributor.authorBelli, LSen_US
dc.contributor.authorScheuer, PJen_US
dc.date.accessioned2012-05-29T06:09:43Z-
dc.date.available2012-05-29T06:09:43Z-
dc.date.issued1991en_US
dc.identifier.citationHistopathology, 1991, v. 18 n. 4, p. 323-330en_US
dc.identifier.issn0309-0167en_US
dc.identifier.urihttp://hdl.handle.net/10722/147881-
dc.description.abstractThe histopathological features of orthotopic liver grafts were studied in 107 serial specimens from 25 patients, to assess the prevalence, possible pathogenesis and prognostic implications of hepatocellular ballooning. Ballooned hepatocytes were found in 46 (54%) of 85 biopsies taken five or more days after transplantation from 16 patients. They were not found in any of the protocol biopsies taken at the time of the operation. Ballooning usually appeared in the second week after transplantation, and in most patients persisted to the time of the latest biopsy studied. The affected cells were always found in acinar zone 3, and sometimes also in other zones. Forty-four of the 46 biopsies with ballooning were taken during a period of clinical and biochemical cholestasis. In 13 of the 16 patients the degree of ballooning paralleled the severity of the cholestasis. Electronmicroscopy of affected hepatocytes showed conspicuous dilatation of the cisternae of the rough endoplasmic reticulum rather than the classical features of cholestasis. It was therefore concluded that ballooning was associated with but not directly caused by bile retention. There was no obvious association between ballooning and cellular rejection, sepsis, immnnosuppressive therapy or parenteral nutrition. The most severe early ballooning was associated with serum transaminase levels over 1000 IU/l within 48 h of transplantation, suggesting that ischaemia was one of the pathogenetic factors. Hepatocellular ballooning did not in itself appear to have sinister short-term prognostic implications.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_US
dc.relation.ispartofHistopathologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAspartate Aminotransferases - Blooden_US
dc.subject.meshBiopsyen_US
dc.subject.meshChilden_US
dc.subject.meshCholestasis - Etiologyen_US
dc.subject.meshDilatation, Pathologic - Complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressionen_US
dc.subject.meshLiver - Pathology - Ultrastructureen_US
dc.subject.meshLiver Transplantation - Mortality - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopyen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshParenteral Nutrition, Totalen_US
dc.titleHepatocellular ballooning after liver transplantation: A light and electronmicroscopic study with clinicopathological correlationen_US
dc.typeArticleen_US
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1906423-
dc.identifier.scopuseid_2-s2.0-0025730532en_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.spage323en_US
dc.identifier.epage330en_US
dc.identifier.isiWOS:A1991FH53400005-
dc.publisher.placeUnited Kingdomen_US

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