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Article: Long-term results of resection for large hepatocellular carcinoma: A multivariate analysis of clinicopathological features

TitleLong-term results of resection for large hepatocellular carcinoma: A multivariate analysis of clinicopathological features
Authors
Issue Date1990
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 1990, v. 11 n. 5, p. 815-818 How to Cite?
AbstractRecurrent or metastatic disease is frequently encountered among patients who have had resection of their primary hepatocellular carcinoma. A retrospective study on 117 patients (104 men, 13 women; mean age ± standard deviation: 53.8 ± 12.4 yr) who had hepatectomy for large hepatocellular carcinoma (diameter ≥ 5 cm) was conducted to identify an at-risk population for tumor recurrence. Disease-free survival was correlated with 22 clinical (n = 5), serological (n = 2), gross pathological (n = 3) and histological (n = 12) features of the resected specimens using Cox's multivariate regression analysis. Recurrent hepatocellular carcinoma was detected in 74 patients within a median follow-up period of 13.7 mo. Although 17 patients had extrahepatic disease alone, recurrence was confined to the hepatic remnant in 40 patients. Disease-free survival rates at 1, 3 and 5 yr were 40% 19% and 12%, respectively. Two of the five histological parameters isolated, negative resection margin (p < 0.01) and encapsulation (p < 0.006), were identified as favorable independent prognostic predictors. When patients with positive margins were excluded from the analysis, repeated calculation showed that encapsulation was the only important determinant. From this analysis, detailed histological study of the resected tumor is seen to be the only satisfactory means for assessing long-term prognosis. An aggressive approach is warranted among patients with encapsulated tumors. Even with a clear resection margin, adjuvant treatment should be considered for those patients who have unencapsulated lesions.
Persistent Identifierhttp://hdl.handle.net/10722/147866
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, ECSen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorNg, MMTen_HK
dc.contributor.authorLok, ASFen_HK
dc.contributor.authorTam, PCen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorChoi, TKen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2012-05-29T06:09:38Z-
dc.date.available2012-05-29T06:09:38Z-
dc.date.issued1990en_HK
dc.identifier.citationHepatology, 1990, v. 11 n. 5, p. 815-818en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147866-
dc.description.abstractRecurrent or metastatic disease is frequently encountered among patients who have had resection of their primary hepatocellular carcinoma. A retrospective study on 117 patients (104 men, 13 women; mean age ± standard deviation: 53.8 ± 12.4 yr) who had hepatectomy for large hepatocellular carcinoma (diameter ≥ 5 cm) was conducted to identify an at-risk population for tumor recurrence. Disease-free survival was correlated with 22 clinical (n = 5), serological (n = 2), gross pathological (n = 3) and histological (n = 12) features of the resected specimens using Cox's multivariate regression analysis. Recurrent hepatocellular carcinoma was detected in 74 patients within a median follow-up period of 13.7 mo. Although 17 patients had extrahepatic disease alone, recurrence was confined to the hepatic remnant in 40 patients. Disease-free survival rates at 1, 3 and 5 yr were 40% 19% and 12%, respectively. Two of the five histological parameters isolated, negative resection margin (p < 0.01) and encapsulation (p < 0.006), were identified as favorable independent prognostic predictors. When patients with positive margins were excluded from the analysis, repeated calculation showed that encapsulation was the only important determinant. From this analysis, detailed histological study of the resected tumor is seen to be the only satisfactory means for assessing long-term prognosis. An aggressive approach is warranted among patients with encapsulated tumors. Even with a clear resection margin, adjuvant treatment should be considered for those patients who have unencapsulated lesions.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Agents - Therapeutic Useen_US
dc.subject.meshCarcinoma, Hepatocellular - Pathology - Physiopathology - Surgeryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Diseases - Pathology - Physiopathology - Surgeryen_US
dc.subject.meshLiver Neoplasmsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTime Factorsen_US
dc.titleLong-term results of resection for large hepatocellular carcinoma: A multivariate analysis of clinicopathological featuresen_HK
dc.typeArticleen_HK
dc.identifier.emailNg, IOL: iolng@hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/hep.1840110516en_HK
dc.identifier.pmid2161393-
dc.identifier.scopuseid_2-s2.0-0025299817en_HK
dc.identifier.volume11en_HK
dc.identifier.issue5en_HK
dc.identifier.spage815en_HK
dc.identifier.epage818en_HK
dc.identifier.isiWOS:A1990DG81800015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, ECS=36932159600en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridNg, MMT=7202076310en_HK
dc.identifier.scopusauthoridLok, ASF=35379868500en_HK
dc.identifier.scopusauthoridTam, PC=7202539419en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridChoi, TK=7202770029en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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