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Article: Ground-glass hepatocytes with Lafora body like inclusions - Histochemical, immunohistochemical and electronmicroscopic characterization

TitleGround-glass hepatocytes with Lafora body like inclusions - Histochemical, immunohistochemical and electronmicroscopic characterization
Authors
Issue Date1990
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 1990, v. 17 n. 2, p. 109-115 How to Cite?
AbstractWe report two adult patients whose liver biopsy specimens revealed numerous ground-glass hepatocytes due to inclusions resembling Lafora bodies. The inclusions were large, intracytoplasmic, pale, eosinophilic and kidney-shaped and were periodic acid-Schiff positive and HBsAg negative. Immunoperoxidase studies showed that the inclusions were positive for cytokeratins and α1-antitrypsin. In case 1, the inclusions were not membrane-bound and consisted of secondary lysosomes and degenerate organelles including rough and smooth endoplasmic reticulum. In case 2, electronmicroscopy showed the inclusions were not membrane-bound, but consisted of dense granules, fibrils and vacuoles, with appearances very similar to Lafora bodies. Neither patient had myoclonus or epilepsy. Electronmicroscopy is important in differentiating the type of Lafora body like inclusions found in liver biopsies.
Persistent Identifierhttp://hdl.handle.net/10722/147855
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNg, IOLen_US
dc.contributor.authorSturgess, RPen_US
dc.contributor.authorWilliams, Ren_US
dc.contributor.authorPortmann, Ben_US
dc.date.accessioned2012-05-29T06:09:35Z-
dc.date.available2012-05-29T06:09:35Z-
dc.date.issued1990en_US
dc.identifier.citationHistopathology, 1990, v. 17 n. 2, p. 109-115en_US
dc.identifier.issn0309-0167en_US
dc.identifier.urihttp://hdl.handle.net/10722/147855-
dc.description.abstractWe report two adult patients whose liver biopsy specimens revealed numerous ground-glass hepatocytes due to inclusions resembling Lafora bodies. The inclusions were large, intracytoplasmic, pale, eosinophilic and kidney-shaped and were periodic acid-Schiff positive and HBsAg negative. Immunoperoxidase studies showed that the inclusions were positive for cytokeratins and α1-antitrypsin. In case 1, the inclusions were not membrane-bound and consisted of secondary lysosomes and degenerate organelles including rough and smooth endoplasmic reticulum. In case 2, electronmicroscopy showed the inclusions were not membrane-bound, but consisted of dense granules, fibrils and vacuoles, with appearances very similar to Lafora bodies. Neither patient had myoclonus or epilepsy. Electronmicroscopy is important in differentiating the type of Lafora body like inclusions found in liver biopsies.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_US
dc.relation.ispartofHistopathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshDementia - Metabolism - Pathologyen_US
dc.subject.meshEpilepsies, Myoclonic - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatic Veno-Occlusive Disease - Metabolism - Pathologyen_US
dc.subject.meshHistocytochemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInclusion Bodies - Pathology - Ultrastructureen_US
dc.subject.meshLiver - Metabolism - Pathology - Ultrastructureen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electronen_US
dc.subject.meshMiddle Ageden_US
dc.titleGround-glass hepatocytes with Lafora body like inclusions - Histochemical, immunohistochemical and electronmicroscopic characterizationen_US
dc.typeArticleen_US
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2172143en_US
dc.identifier.scopuseid_2-s2.0-0025078423en_US
dc.identifier.volume17en_US
dc.identifier.issue2en_US
dc.identifier.spage109en_US
dc.identifier.epage115en_US
dc.identifier.isiWOS:A1990DU73100002-
dc.publisher.placeUnited Kingdomen_US

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