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Article: Natural history of campylobacter pylori in duodenal ulceration treated with an H 2-antagonist

TitleNatural history of campylobacter pylori in duodenal ulceration treated with an H 2-antagonist
Authors
Issue Date1989
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 1989, v. 3 n. 3, p. 315-320 How to Cite?
AbstractCampylobacter pylori has been associated closely with active antral gastritis and duodenal ulcer but its pathogenetic role remains uncertain. The present longitudinal study examined, prospectively, the endoscopic antral biopsies of 45 patients with duodenal ulceration, taken before and after healing of the duodenal ulcer, during remission and at relapse. The biopsies were examined for the activity and degree of chronic inflammation of the gastritis and for the occurrence and density of C.pylori by Warthin-Starry stain. Before treatment the frequency of chronic active antral gastritis was 100% and the occurrence of C.pylori was 97%. Compared with the pre-treatment state, there was no significant change in either the frequency and severity of antral gastritis, or in the occurrence and density of the bacteria in the antral mucosa at the time the duodenal ulcer healed, during remission, or at relapse. The occurrence of the bacteria was significantly more frequent during remission, than at the time when the ulcer had healed initially (P < 0.05). These results suggest that the bacterium may not play an important pathogenetic role in ulcer healing and relapse, when patients are managed using an H 2-blocker.
Persistent Identifierhttp://hdl.handle.net/10722/147848
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHo, Jen_US
dc.contributor.authorHui, WMen_US
dc.contributor.authorNg, Ien_US
dc.contributor.authorLam, SKen_US
dc.date.accessioned2012-05-29T06:09:32Z-
dc.date.available2012-05-29T06:09:32Z-
dc.date.issued1989en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 1989, v. 3 n. 3, p. 315-320en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/147848-
dc.description.abstractCampylobacter pylori has been associated closely with active antral gastritis and duodenal ulcer but its pathogenetic role remains uncertain. The present longitudinal study examined, prospectively, the endoscopic antral biopsies of 45 patients with duodenal ulceration, taken before and after healing of the duodenal ulcer, during remission and at relapse. The biopsies were examined for the activity and degree of chronic inflammation of the gastritis and for the occurrence and density of C.pylori by Warthin-Starry stain. Before treatment the frequency of chronic active antral gastritis was 100% and the occurrence of C.pylori was 97%. Compared with the pre-treatment state, there was no significant change in either the frequency and severity of antral gastritis, or in the occurrence and density of the bacteria in the antral mucosa at the time the duodenal ulcer healed, during remission, or at relapse. The occurrence of the bacteria was significantly more frequent during remission, than at the time when the ulcer had healed initially (P < 0.05). These results suggest that the bacterium may not play an important pathogenetic role in ulcer healing and relapse, when patients are managed using an H 2-blocker.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.subject.meshAdulten_US
dc.subject.meshCampylobacter - Drug Effectsen_US
dc.subject.meshCampylobacter Infections - Drug Therapy - Pathologyen_US
dc.subject.meshCimetidine - Therapeutic Useen_US
dc.subject.meshDuodenal Ulcer - Drug Therapy - Microbiology - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastric Mucosa - Microbiology - Pathologyen_US
dc.subject.meshHistamine H2 Antagonists - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshRanitidine - Therapeutic Useen_US
dc.subject.meshRecurrenceen_US
dc.titleNatural history of campylobacter pylori in duodenal ulceration treated with an H 2-antagonisten_US
dc.typeArticleen_US
dc.identifier.emailNg, I:iolng@hkucc.hku.hken_US
dc.identifier.authorityNg, I=rp00335en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2577695en_US
dc.identifier.scopuseid_2-s2.0-0024956043en_US
dc.identifier.volume3en_US
dc.identifier.issue3en_US
dc.identifier.spage315en_US
dc.identifier.epage320en_US
dc.identifier.isiWOS:A1989AJ67700012-
dc.publisher.placeUnited Kingdomen_US

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