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Article: Roles of spike protein in the pathogenesis of SARS coronavirus.

TitleRoles of spike protein in the pathogenesis of SARS coronavirus.
Authors
Issue Date2009
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 2, p. 37-40 How to Cite?
Abstract1. Infection with SARS coronavirus (SARS-CoV) induces a cellular stress condition known as the unfolded protein response (UPR). UPR induction is mediated primarily by viral spike (S) protein. The modulation of UPR by S protein involves activation of PERK protein kinase. Other branches of the UPR pathways controlled by IRE1 and ATF6 proteins, respectively, are not involved. 2. The protease inhibitor Ben-HCl effectively suppresses SARS-CoV infection by blocking virus entry. Viral infectivity is associated with the cleavage of S protein by the cellular protease factor Xa. 3. Two new aspects of the interaction between SARS-CoV S protein and the cell have been defined. These have important implications in the pathogenesis of SARS, providing opportunities for developing vaccines and antivirals against SARS-CoV. 4. Counteracting the UPR and targeting the cleavage of S protein with small molecule pharmaceutical agents represent two new anti-SARS-CoV strategies. 5. The receptor-binding domain of S protein delivered via adeno-associated virus can efficiently induce mucosal immunity and provide long-term protection against SARS-CoV infection.
Persistent Identifierhttp://hdl.handle.net/10722/147614
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorJin, DYen_HK
dc.contributor.authorZheng, BJen_HK
dc.date.accessioned2012-05-29T06:04:59Z-
dc.date.available2012-05-29T06:04:59Z-
dc.date.issued2009en_HK
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2009, v. 15 Suppl 2, p. 37-40en_HK
dc.identifier.issn1024-2708en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147614-
dc.description.abstract1. Infection with SARS coronavirus (SARS-CoV) induces a cellular stress condition known as the unfolded protein response (UPR). UPR induction is mediated primarily by viral spike (S) protein. The modulation of UPR by S protein involves activation of PERK protein kinase. Other branches of the UPR pathways controlled by IRE1 and ATF6 proteins, respectively, are not involved. 2. The protease inhibitor Ben-HCl effectively suppresses SARS-CoV infection by blocking virus entry. Viral infectivity is associated with the cleavage of S protein by the cellular protease factor Xa. 3. Two new aspects of the interaction between SARS-CoV S protein and the cell have been defined. These have important implications in the pathogenesis of SARS, providing opportunities for developing vaccines and antivirals against SARS-CoV. 4. Counteracting the UPR and targeting the cleavage of S protein with small molecule pharmaceutical agents represent two new anti-SARS-CoV strategies. 5. The receptor-binding domain of S protein delivered via adeno-associated virus can efficiently induce mucosal immunity and provide long-term protection against SARS-CoV infection.en_HK
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_HK
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCercopithecus Aethiopsen_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshFactor Xa - Metabolismen_US
dc.subject.meshMembrane Glycoproteins - Metabolismen_US
dc.subject.meshProtease Inhibitors - Pharmacologyen_US
dc.subject.meshProtein Folding - Drug Effectsen_US
dc.subject.meshSars Virus - Drug Effects - Metabolismen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Prevention & Controlen_US
dc.subject.meshVero Cellsen_US
dc.subject.meshViral Envelope Proteins - Metabolismen_US
dc.subject.meshVirus Internalization - Drug Effectsen_US
dc.subject.meshEif-2 Kinase - Metabolismen_US
dc.titleRoles of spike protein in the pathogenesis of SARS coronavirus.en_HK
dc.typeArticleen_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.emailZheng, BJ:bzheng@hkucc.hku.hken_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.identifier.authorityZheng, BJ=rp00353en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid19258633-
dc.identifier.scopuseid_2-s2.0-70649102469en_HK
dc.identifier.volume15 Suppl 2en_HK
dc.identifier.spage37en_HK
dc.identifier.epage40en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.scopusauthoridZheng, BJ=7201780588en_HK

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