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Article: Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia

TitleSubcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia
Authors
Issue Date2004
PublisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.org
Citation
Biochemical Journal, 2004, v. 383 n. 1, p. 27-35 How to Cite?
AbstractEEN (extra eleven nineteen), also known as EA2 (endophilin A2), a fusion partner of the MLL (mixed-lineage leukaemia) gene in human acute leukaemia, is a member of the endophilin A family, involved in the formation of endocytic vesicles. We present evidence to show that EEN/EA2 is localized predominantly in nuclei of various cell lines of haemopoietic, fibroblast and epithelial origin, in contrast with its reported cytoplasmic localization in neurons and osteoclasts, and that EEN/EA2 exhibits nucleocytoplasmic shuttling. During the cell cycle, EEN/EA2 shows dynamic localization: it is perichromosomal in prometaphase, co-localizes with the bipolar spindle in metaphase and anaphase and redistributes to the midzone and midbody in telophase. This pattern of distribution coincides with changes in protein levels of EEN/EA2, with the highest levels being observed in G 2/M-phase. Our results suggest that distinct subcellular localization of the endophilin A family members probably underpins their diverse cellular functions and indicates a role for EEN/EA2 in the cell cycle.
Persistent Identifierhttp://hdl.handle.net/10722/147599
ISSN
2015 Impact Factor: 3.562
2015 SCImago Journal Rankings: 2.582
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorSo, CWen_US
dc.contributor.authorYam, JWPen_US
dc.contributor.authorSo, CKCen_US
dc.contributor.authorPoon, RYCen_US
dc.contributor.authorJin, DYen_US
dc.contributor.authorChan, LCen_US
dc.date.accessioned2012-05-29T06:04:52Z-
dc.date.available2012-05-29T06:04:52Z-
dc.date.issued2004en_US
dc.identifier.citationBiochemical Journal, 2004, v. 383 n. 1, p. 27-35en_US
dc.identifier.issn0264-6021en_US
dc.identifier.urihttp://hdl.handle.net/10722/147599-
dc.description.abstractEEN (extra eleven nineteen), also known as EA2 (endophilin A2), a fusion partner of the MLL (mixed-lineage leukaemia) gene in human acute leukaemia, is a member of the endophilin A family, involved in the formation of endocytic vesicles. We present evidence to show that EEN/EA2 is localized predominantly in nuclei of various cell lines of haemopoietic, fibroblast and epithelial origin, in contrast with its reported cytoplasmic localization in neurons and osteoclasts, and that EEN/EA2 exhibits nucleocytoplasmic shuttling. During the cell cycle, EEN/EA2 shows dynamic localization: it is perichromosomal in prometaphase, co-localizes with the bipolar spindle in metaphase and anaphase and redistributes to the midzone and midbody in telophase. This pattern of distribution coincides with changes in protein levels of EEN/EA2, with the highest levels being observed in G 2/M-phase. Our results suggest that distinct subcellular localization of the endophilin A family members probably underpins their diverse cellular functions and indicates a role for EEN/EA2 in the cell cycle.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.biochemj.orgen_US
dc.relation.ispartofBiochemical Journalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Specificityen_US
dc.subject.meshCell Cycle - Physiologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Nucleus - Metabolismen_US
dc.subject.meshCytoplasm - Metabolismen_US
dc.subject.meshEndocytosis - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIntracellular Signaling Peptides And Proteinsen_US
dc.subject.meshLeukemia - Metabolismen_US
dc.subject.meshMitosis - Physiologyen_US
dc.subject.meshProtein Transporten_US
dc.subject.meshProteins - Immunology - Metabolism - Physiologyen_US
dc.subject.meshSequence Deletionen_US
dc.subject.meshSubcellular Fractions - Metabolismen_US
dc.subject.meshSrc Homology Domainsen_US
dc.titleSubcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailYam, JWP:judyyam@pathology.hku.hken_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_US
dc.identifier.authorityYam, JWP=rp00468en_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.identifier.authorityChan, LC=rp00373en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1042/BJ20040041en_US
dc.identifier.pmid15214844-
dc.identifier.pmcidPMC1134040-
dc.identifier.scopuseid_2-s2.0-6344248913en_US
dc.identifier.hkuros90268-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-6344248913&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume383en_US
dc.identifier.issue1en_US
dc.identifier.spage27en_US
dc.identifier.epage35en_US
dc.identifier.isiWOS:000224537800004-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, N=36803314200en_US
dc.identifier.scopusauthoridSo, CW=7102919928en_US
dc.identifier.scopusauthoridYam, JWP=6603711123en_US
dc.identifier.scopusauthoridSo, CKC=7102919975en_US
dc.identifier.scopusauthoridPoon, RYC=7103097213en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridChan, LC=7403540707en_US

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