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Article: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

TitleA genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
Authors
Issue Date2007
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2007, v. 39 n. 7, p. 870-874 How to Cite?
AbstractWe conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies. Across the four studies, the association with all four SNPs was highly statistically significant (Ptrend for the most strongly associated SNP (rs1219648) = 1.1 × 10-10; population attributable risk = 16%). Four SNPs at other loci most strongly associated with breast cancer in the initial GWAS were not associated in the replication studies. Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci. © 2007 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/147562
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHunter, DJen_US
dc.contributor.authorKraft, Pen_US
dc.contributor.authorJacobs, KBen_US
dc.contributor.authorCox, DGen_US
dc.contributor.authorYeager, Men_US
dc.contributor.authorHankinson, SEen_US
dc.contributor.authorWacholder, Sen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorWelch, Ren_US
dc.contributor.authorHutchinson, Aen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorYu, Ken_US
dc.contributor.authorChatterjee, Nen_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorWillett, WCen_US
dc.contributor.authorColditz, GAen_US
dc.contributor.authorZiegler, RGen_US
dc.contributor.authorBerg, CDen_US
dc.contributor.authorBuys, SSen_US
dc.contributor.authorMccarty, CAen_US
dc.contributor.authorFeigelson, HSen_US
dc.contributor.authorCalle, EEen_US
dc.contributor.authorThun, MJen_US
dc.contributor.authorHayes, RBen_US
dc.contributor.authorTucker, Men_US
dc.contributor.authorGerhard, DSen_US
dc.contributor.authorFraumeni, JFen_US
dc.contributor.authorHoover, RNen_US
dc.contributor.authorThomas, Gen_US
dc.contributor.authorChanock, SJen_US
dc.date.accessioned2012-05-29T06:04:38Z-
dc.date.available2012-05-29T06:04:38Z-
dc.date.issued2007en_US
dc.identifier.citationNature Genetics, 2007, v. 39 n. 7, p. 870-874en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/147562-
dc.description.abstractWe conducted a genome-wide association study (GWAS) of breast cancer by genotyping 528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast cancer and 1,142 controls. We identified four SNPs in intron 2 of FGFR2 (which encodes a receptor tyrosine kinase and is amplified or overexpressed in some breast cancers) that were highly associated with breast cancer and confirmed this association in 1,776 affected individuals and 2,072 controls from three additional studies. Across the four studies, the association with all four SNPs was highly statistically significant (Ptrend for the most strongly associated SNP (rs1219648) = 1.1 × 10-10; population attributable risk = 16%). Four SNPs at other loci most strongly associated with breast cancer in the initial GWAS were not associated in the replication studies. Our summary results from the GWAS are available online in a form that should speed the identification of additional risk loci. © 2007 Nature Publishing Group.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshAgeden_US
dc.subject.meshAllelesen_US
dc.subject.meshBreast Neoplasms - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenome, Humanen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshPostmenopauseen_US
dc.subject.meshReceptor, Fibroblast Growth Factor, Type 2 - Geneticsen_US
dc.subject.meshRisk Factorsen_US
dc.titleA genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast canceren_US
dc.typeArticleen_US
dc.identifier.emailWang, J:junwen@hkucc.hku.hken_US
dc.identifier.authorityWang, J=rp00280en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng2075en_US
dc.identifier.pmid17529973-
dc.identifier.scopuseid_2-s2.0-34250001297en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250001297&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume39en_US
dc.identifier.issue7en_US
dc.identifier.spage870en_US
dc.identifier.epage874en_US
dc.identifier.eissn1546-1718-
dc.identifier.isiWOS:000247619800017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridHunter, DJ=36064393800en_US
dc.identifier.scopusauthoridKraft, P=8678864000en_US
dc.identifier.scopusauthoridJacobs, KB=7202908205en_US
dc.identifier.scopusauthoridCox, DG=7403241038en_US
dc.identifier.scopusauthoridYeager, M=35379327500en_US
dc.identifier.scopusauthoridHankinson, SE=7102950324en_US
dc.identifier.scopusauthoridWacholder, S=7005906464en_US
dc.identifier.scopusauthoridWang, Z=35346086300en_US
dc.identifier.scopusauthoridWelch, R=7201912644en_US
dc.identifier.scopusauthoridHutchinson, A=35381552100en_US
dc.identifier.scopusauthoridWang, J=8950599500en_US
dc.identifier.scopusauthoridYu, K=7403385290en_US
dc.identifier.scopusauthoridChatterjee, N=7102740943en_US
dc.identifier.scopusauthoridOrr, N=16245676700en_US
dc.identifier.scopusauthoridWillett, WC=36042830300en_US
dc.identifier.scopusauthoridColditz, GA=35380981000en_US
dc.identifier.scopusauthoridZiegler, RG=7201587134en_US
dc.identifier.scopusauthoridBerg, CD=7202716872en_US
dc.identifier.scopusauthoridBuys, SS=7004195562en_US
dc.identifier.scopusauthoridMcCarty, CA=34880447300en_US
dc.identifier.scopusauthoridFeigelson, HS=7004523268en_US
dc.identifier.scopusauthoridCalle, EE=7005657669en_US
dc.identifier.scopusauthoridThun, MJ=7006846858en_US
dc.identifier.scopusauthoridHayes, RB=7402082381en_US
dc.identifier.scopusauthoridTucker, M=7201659716en_US
dc.identifier.scopusauthoridGerhard, DS=7004060116en_US
dc.identifier.scopusauthoridFraumeni, JF=35374106200en_US
dc.identifier.scopusauthoridHoover, RN=7202691823en_US
dc.identifier.scopusauthoridThomas, G=7404576615en_US
dc.identifier.scopusauthoridChanock, SJ=7006047196en_US
dc.identifier.citeulike1420716-

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