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Article: Search for basonuclin target genes

TitleSearch for basonuclin target genes
Authors
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description
Citation
Biochemical And Biophysical Research Communications, 2006, v. 348 n. 4, p. 1261-1271 How to Cite?
AbstractBasonuclin (Bnc 1) is a transcription factor that has an unusual ability to interact with promoters of both RNA polymerases I and II. The action of basonuclin is mediated through three pairs of evolutionarily conserved zinc fingers, which produce three DNase I footprints on the promoters of rDNA and the basonuclin gene. Using these DNase footprints, we built a computational model for the basonuclin DNA-binding module, which was used to identify in silico potential RNA polymerase II target genes in the human and mouse promoter databases. The target genes of basonuclin show that it regulates the expression of proteins involved in chromatin structure, transcription/DNA-binding, ion-channels, adhesion/cell-cell junction, signal transduction, and intracellular transport. Our results suggest that basonuclin, like MYC, may coordinate transcriptional activities among the three RNA polymerases. But basonuclin regulates a distinctive set of pathways, which differ from that regulated by MYC. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147543
ISSN
2015 Impact Factor: 2.371
2015 SCImago Journal Rankings: 1.152
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Jen_US
dc.contributor.authorZhang, Sen_US
dc.contributor.authorSchultz, RMen_US
dc.contributor.authorTseng, Hen_US
dc.date.accessioned2012-05-29T06:04:28Z-
dc.date.available2012-05-29T06:04:28Z-
dc.date.issued2006en_US
dc.identifier.citationBiochemical And Biophysical Research Communications, 2006, v. 348 n. 4, p. 1261-1271en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/147543-
dc.description.abstractBasonuclin (Bnc 1) is a transcription factor that has an unusual ability to interact with promoters of both RNA polymerases I and II. The action of basonuclin is mediated through three pairs of evolutionarily conserved zinc fingers, which produce three DNase I footprints on the promoters of rDNA and the basonuclin gene. Using these DNase footprints, we built a computational model for the basonuclin DNA-binding module, which was used to identify in silico potential RNA polymerase II target genes in the human and mouse promoter databases. The target genes of basonuclin show that it regulates the expression of proteins involved in chromatin structure, transcription/DNA-binding, ion-channels, adhesion/cell-cell junction, signal transduction, and intracellular transport. Our results suggest that basonuclin, like MYC, may coordinate transcriptional activities among the three RNA polymerases. But basonuclin regulates a distinctive set of pathways, which differ from that regulated by MYC. © 2006 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/descriptionen_US
dc.relation.ispartofBiochemical and Biophysical Research Communicationsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCell Lineen_US
dc.subject.meshChromatin Immunoprecipitationen_US
dc.subject.meshComputational Biologyen_US
dc.subject.meshConserved Sequenceen_US
dc.subject.meshDna-Binding Proteins - Metabolismen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPhosphoproteins - Metabolismen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshTranscription Factors - Metabolismen_US
dc.subject.meshZinc Fingersen_US
dc.titleSearch for basonuclin target genesen_US
dc.typeArticleen_US
dc.identifier.emailWang, J:junwen@hkucc.hku.hken_US
dc.identifier.authorityWang, J=rp00280en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.bbrc.2006.07.198en_US
dc.identifier.pmid16919236-
dc.identifier.scopuseid_2-s2.0-33747882082en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747882082&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume348en_US
dc.identifier.issue4en_US
dc.identifier.spage1261en_US
dc.identifier.epage1271en_US
dc.identifier.isiWOS:000240425600008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, J=8950599500en_US
dc.identifier.scopusauthoridZhang, S=14319464100en_US
dc.identifier.scopusauthoridSchultz, RM=7401556658en_US
dc.identifier.scopusauthoridTseng, H=19637691100en_US

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