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Article: Inhibition of XJ-160 virus replication by RNAi

TitleInhibition of XJ-160 virus replication by RNAi
Authors
KeywordsAntiviral Effects
Rnai
Sirna
Virus Replication
Xj-160 Virus
Issue Date2005
Citation
Chinese Journal Of Microbiology And Immunology, 2005, v. 25 n. 6, p. 496-500 How to Cite?
AbstractObjective: By construct the model of RNAi-mediated inhibition of XJ-160 virus replication to study RNAi-mediated inhibition of XJ-160 virus replication on aspect of sequence, positional and dose dependent, to further research on effect and mechanism of RNAi on antiviral effects. Methods: Synthesized the XJ-160 virus special short interferencing RNA (siRNA) according to the requiring of siRNA design. siRNA was transfected into BHK-21 cells via liposomes, then infected the BHK-21 cells by XJ-160 virus. Through detecting the titer, protein expression and RNA synthesizing of XJ-160 virus, research on siRNA-mediated inhibition of XJ-160 virus replication. Results: Constructed the model of RNAi-mediated inhibition of XJ-160 virus replication successfully, and discussed the character of it. Conclusion: siRNA can inhibit the replication of XJ-160 virus. It has sequence, positional and dose dependent. And it is carried out by digested the virus RNA.
Persistent Identifierhttp://hdl.handle.net/10722/147522
ISSN
2015 SCImago Journal Rankings: 0.108
References

 

DC FieldValueLanguage
dc.contributor.authorDeng, Jen_US
dc.contributor.authorYang, YLen_US
dc.contributor.authorFu, SHen_US
dc.contributor.authorWang, LHen_US
dc.contributor.authorJin, DYen_US
dc.contributor.authorLiang, GDen_US
dc.date.accessioned2012-05-29T06:04:20Z-
dc.date.available2012-05-29T06:04:20Z-
dc.date.issued2005en_US
dc.identifier.citationChinese Journal Of Microbiology And Immunology, 2005, v. 25 n. 6, p. 496-500en_US
dc.identifier.issn0254-5101en_US
dc.identifier.urihttp://hdl.handle.net/10722/147522-
dc.description.abstractObjective: By construct the model of RNAi-mediated inhibition of XJ-160 virus replication to study RNAi-mediated inhibition of XJ-160 virus replication on aspect of sequence, positional and dose dependent, to further research on effect and mechanism of RNAi on antiviral effects. Methods: Synthesized the XJ-160 virus special short interferencing RNA (siRNA) according to the requiring of siRNA design. siRNA was transfected into BHK-21 cells via liposomes, then infected the BHK-21 cells by XJ-160 virus. Through detecting the titer, protein expression and RNA synthesizing of XJ-160 virus, research on siRNA-mediated inhibition of XJ-160 virus replication. Results: Constructed the model of RNAi-mediated inhibition of XJ-160 virus replication successfully, and discussed the character of it. Conclusion: siRNA can inhibit the replication of XJ-160 virus. It has sequence, positional and dose dependent. And it is carried out by digested the virus RNA.en_US
dc.languageengen_US
dc.relation.ispartofChinese Journal of Microbiology and Immunologyen_US
dc.subjectAntiviral Effectsen_US
dc.subjectRnaien_US
dc.subjectSirnaen_US
dc.subjectVirus Replicationen_US
dc.subjectXj-160 Virusen_US
dc.titleInhibition of XJ-160 virus replication by RNAien_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-24944513894en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24944513894&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume25en_US
dc.identifier.issue6en_US
dc.identifier.spage496en_US
dc.identifier.epage500en_US
dc.identifier.scopusauthoridDeng, J=7402613242en_US
dc.identifier.scopusauthoridYang, YL=8985908500en_US
dc.identifier.scopusauthoridFu, SH=14057935200en_US
dc.identifier.scopusauthoridWang, LH=8912385300en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridLiang, GD=7202631120en_US

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