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Article: The transcriptional control of trunk neural crest induction, survival, and delamination

TitleThe transcriptional control of trunk neural crest induction, survival, and delamination
Authors
Issue Date2005
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/devcel
Citation
Developmental Cell, 2005, v. 8 n. 2, p. 179-192 How to Cite?
AbstractTrunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of transcription induce these properties in premigratory neural crest cells. Sox9 acts to provide the competence for neural crest cells to undergo an EMT and is required for trunk neural crest survival. In the absence of Sox9, cells apoptose prior to or shortly after delamination. Slug/Snail, in the presence of Sox9, is sufficient to induce an EMT in neural epithelial cells, while FoxD3 regulates the expression of cell-cell adhesion molecules required for neural crest migration. Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells. Copyright © 2005 by Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/147501
ISSN
2015 Impact Factor: 9.338
2015 SCImago Journal Rankings: 7.338
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Men_US
dc.contributor.authorChaboissier, MCen_US
dc.contributor.authorMynett, Aen_US
dc.contributor.authorHirst, Een_US
dc.contributor.authorSchedl, Aen_US
dc.contributor.authorBriscoe, Jen_US
dc.date.accessioned2012-05-29T06:04:10Z-
dc.date.available2012-05-29T06:04:10Z-
dc.date.issued2005en_US
dc.identifier.citationDevelopmental Cell, 2005, v. 8 n. 2, p. 179-192en_US
dc.identifier.issn1534-5807en_US
dc.identifier.urihttp://hdl.handle.net/10722/147501-
dc.description.abstractTrunk neural crest cells are generated at the border between the neural plate and nonneural ectoderm, where they initiate a distinct program of gene expression, undergo an epithelial-mesenchymal transition (EMT), and delaminate from the neuroepithelium. Here, we provide evidence that members of three families of transcription induce these properties in premigratory neural crest cells. Sox9 acts to provide the competence for neural crest cells to undergo an EMT and is required for trunk neural crest survival. In the absence of Sox9, cells apoptose prior to or shortly after delamination. Slug/Snail, in the presence of Sox9, is sufficient to induce an EMT in neural epithelial cells, while FoxD3 regulates the expression of cell-cell adhesion molecules required for neural crest migration. Together, the data suggest a model in which a combination of transcription factors regulates the acquisition of the diverse properties of neural crest cells. Copyright © 2005 by Elsevier Inc.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/devcelen_US
dc.relation.ispartofDevelopmental Cellen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosisen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshDna-Binding Proteins - Genetics - Physiologyen_US
dc.subject.meshEmbryonic Induction - Geneticsen_US
dc.subject.meshEpithelium - Embryologyen_US
dc.subject.meshForkhead Transcription Factorsen_US
dc.subject.meshGene Expression Regulation, Developmentalen_US
dc.subject.meshHigh Mobility Group Proteins - Deficiency - Genetics - Physiologyen_US
dc.subject.meshMesoderm - Cytologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshNeural Crest - Embryologyen_US
dc.subject.meshRepressor Proteins - Genetics - Physiologyen_US
dc.subject.meshSox9 Transcription Factoren_US
dc.subject.meshTranscription Factors - Deficiency - Genetics - Physiologyen_US
dc.subject.meshTranscription, Geneticen_US
dc.subject.meshTransfectionen_US
dc.subject.meshRhob Gtp-Binding Protein - Genetics - Physiologyen_US
dc.titleThe transcriptional control of trunk neural crest induction, survival, and delaminationen_US
dc.typeArticleen_US
dc.identifier.emailCheung, M:mcheung9@hkucc.hku.hken_US
dc.identifier.authorityCheung, M=rp00245en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.devcel.2004.12.010en_US
dc.identifier.pmid15691760-
dc.identifier.scopuseid_2-s2.0-13344259902en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13344259902&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.issue2en_US
dc.identifier.spage179en_US
dc.identifier.epage192en_US
dc.identifier.isiWOS:000226875500009-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001025022-
dc.identifier.scopusauthoridCheung, M=7201897461en_US
dc.identifier.scopusauthoridChaboissier, MC=6701908832en_US
dc.identifier.scopusauthoridMynett, A=6701334904en_US
dc.identifier.scopusauthoridHirst, E=16211755800en_US
dc.identifier.scopusauthoridSchedl, A=7003414338en_US
dc.identifier.scopusauthoridBriscoe, J=7005150612en_US

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