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Article: Neural crest development is regulated by the transcription factor Sox9

TitleNeural crest development is regulated by the transcription factor Sox9
Authors
Issue Date2003
Citation
Development, 2003, v. 130 n. 23, p. 5681-5693 How to Cite?
AbstractThe neural crest is a transient migratory population of stem cells derived from the dorsal neural folds at the border between neural and non-neural ectoderm. Following induction, prospective neural crest cells are segregated within the neuroepithelium and then delaminate from the neural tube and migrate into the periphery, where they generate multiple differentiated cell types. The intrinsic determinants that direct this process are not well defined. Group E Sox genes (Sox8, Sox9 and Sox10) are expressed in the prospective neural crest and Sox9 expression precedes expression of premigratory neural crest markers. Here, we show that group E Sox genes act at two distinct steps in neural crest differentiation. Forced expression of Sox9 promotes neural-crest-like properties in neural tube progenitors at the expense of central nervous system neuronal differentiation. Subsequently, in migratory neural crest cells, SoxE gene expression biases cells towards glial cell and melanocyte fate, and away from neuronal lineages. Although SoxE genes are sufficient to initiate neural crest development they do not efficiently induce the delamination of ectopic neural crest cells from the neural tube consistent with the idea that this event is independently controlled. Together, these data identify a role for group E Sox genes in the initiation of neural crest development and later SoxE genes influence the differentiation pathway adopted by migrating neural crest cells.
Persistent Identifierhttp://hdl.handle.net/10722/147492
ISSN
2015 Impact Factor: 6.059
2015 SCImago Journal Rankings: 5.239
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Men_US
dc.contributor.authorBriscoe, Jen_US
dc.date.accessioned2012-05-29T06:04:06Z-
dc.date.available2012-05-29T06:04:06Z-
dc.date.issued2003en_US
dc.identifier.citationDevelopment, 2003, v. 130 n. 23, p. 5681-5693en_US
dc.identifier.issn0950-1991en_US
dc.identifier.urihttp://hdl.handle.net/10722/147492-
dc.description.abstractThe neural crest is a transient migratory population of stem cells derived from the dorsal neural folds at the border between neural and non-neural ectoderm. Following induction, prospective neural crest cells are segregated within the neuroepithelium and then delaminate from the neural tube and migrate into the periphery, where they generate multiple differentiated cell types. The intrinsic determinants that direct this process are not well defined. Group E Sox genes (Sox8, Sox9 and Sox10) are expressed in the prospective neural crest and Sox9 expression precedes expression of premigratory neural crest markers. Here, we show that group E Sox genes act at two distinct steps in neural crest differentiation. Forced expression of Sox9 promotes neural-crest-like properties in neural tube progenitors at the expense of central nervous system neuronal differentiation. Subsequently, in migratory neural crest cells, SoxE gene expression biases cells towards glial cell and melanocyte fate, and away from neuronal lineages. Although SoxE genes are sufficient to initiate neural crest development they do not efficiently induce the delamination of ectopic neural crest cells from the neural tube consistent with the idea that this event is independently controlled. Together, these data identify a role for group E Sox genes in the initiation of neural crest development and later SoxE genes influence the differentiation pathway adopted by migrating neural crest cells.en_US
dc.languageengen_US
dc.relation.ispartofDevelopmenten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Cd57 - Genetics - Metabolismen_US
dc.subject.meshBiological Markersen_US
dc.subject.meshBone Morphogenetic Proteins - Metabolismen_US
dc.subject.meshCell Differentiation - Physiologyen_US
dc.subject.meshCell Lineageen_US
dc.subject.meshCell Movementen_US
dc.subject.meshChick Embryo - Anatomy & Histology - Physiologyen_US
dc.subject.meshCulture Techniquesen_US
dc.subject.meshEmbryonic Inductionen_US
dc.subject.meshHigh Mobility Group Proteins - Genetics - Metabolismen_US
dc.subject.meshMelanocytes - Metabolismen_US
dc.subject.meshNeural Crest - Cytology - Growth & Development - Physiologyen_US
dc.subject.meshNeuroglia - Metabolismen_US
dc.subject.meshNeurons - Cytology - Metabolismen_US
dc.subject.meshProto-Oncogene Proteins - Metabolismen_US
dc.subject.meshRecombinant Fusion Proteins - Genetics - Metabolismen_US
dc.subject.meshSox9 Transcription Factoren_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshStem Cells - Cytology - Physiologyen_US
dc.subject.meshTranscription Factors - Genetics - Metabolismen_US
dc.subject.meshWnt Proteinsen_US
dc.subject.meshZebrafish Proteinsen_US
dc.titleNeural crest development is regulated by the transcription factor Sox9en_US
dc.typeArticleen_US
dc.identifier.emailCheung, M:mcheung9@hkucc.hku.hken_US
dc.identifier.authorityCheung, M=rp00245en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1242/dev.00808en_US
dc.identifier.pmid14522876-
dc.identifier.scopuseid_2-s2.0-0346121540en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346121540&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume130en_US
dc.identifier.issue23en_US
dc.identifier.spage5681en_US
dc.identifier.epage5693en_US
dc.identifier.isiWOS:000187399900010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, M=7201897461en_US
dc.identifier.scopusauthoridBriscoe, J=7005150612en_US

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