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Article: Stimulation of IKK-γ oligomerization by the human T-cell leukemia virus oncoprotein Tax

TitleStimulation of IKK-γ oligomerization by the human T-cell leukemia virus oncoprotein Tax
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
FEBS Letters, 2002, v. 531 n. 3, p. 494-498 How to Cite?
AbstractHuman T-cell leukemia virus type 1 oncoprotein Tax activates NF-κB through direct binding to IKK-γ, the regulatory component of the IκB kinase complex. Mechanisms by which IKK-γ adapts the Tax signal to the IκB kinase are poorly understood. Here we demonstrate that IKK-γ forms homodimer and homotrimer both in vitro and in yeast or mammalian cells through a C-terminal domain comprising amino acids 251-419. In contrast, Tax protein targets a central region of IKK-γ, which consists of amino acids 201-250. Interestingly, Tax stimulates the oligomerization of IKK-γ, likely through direct binding. Taken together, our findings suggest a new model of Tax activation of NF-κB, in which Tax interacts with IKK-γ to stimulate its oligomerization. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147477
ISSN
2015 Impact Factor: 3.519
2015 SCImago Journal Rankings: 2.026
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHuang, GJen_US
dc.contributor.authorZhang, ZQen_US
dc.contributor.authorJin, DYen_US
dc.date.accessioned2012-05-29T06:04:00Z-
dc.date.available2012-05-29T06:04:00Z-
dc.date.issued2002en_US
dc.identifier.citationFEBS Letters, 2002, v. 531 n. 3, p. 494-498en_US
dc.identifier.issn0014-5793en_US
dc.identifier.urihttp://hdl.handle.net/10722/147477-
dc.description.abstractHuman T-cell leukemia virus type 1 oncoprotein Tax activates NF-κB through direct binding to IKK-γ, the regulatory component of the IκB kinase complex. Mechanisms by which IKK-γ adapts the Tax signal to the IκB kinase are poorly understood. Here we demonstrate that IKK-γ forms homodimer and homotrimer both in vitro and in yeast or mammalian cells through a C-terminal domain comprising amino acids 251-419. In contrast, Tax protein targets a central region of IKK-γ, which consists of amino acids 201-250. Interestingly, Tax stimulates the oligomerization of IKK-γ, likely through direct binding. Taken together, our findings suggest a new model of Tax activation of NF-κB, in which Tax interacts with IKK-γ to stimulate its oligomerization. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_US
dc.relation.ispartofFEBS Lettersen_US
dc.subject.meshBiopolymers - Chemistry - Metabolismen_US
dc.subject.meshGene Products, Tax - Physiologyen_US
dc.subject.meshHela Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshI-Kappa B Kinaseen_US
dc.subject.meshProtein-Serine-Threonine Kinases - Chemistry - Metabolismen_US
dc.subject.meshTwo-Hybrid System Techniquesen_US
dc.titleStimulation of IKK-γ oligomerization by the human T-cell leukemia virus oncoprotein Taxen_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0014-5793(02)03590-1en_US
dc.identifier.pmid12435599-
dc.identifier.scopuseid_2-s2.0-0037145860en_US
dc.identifier.hkuros80454-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037145860&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume531en_US
dc.identifier.issue3en_US
dc.identifier.spage494en_US
dc.identifier.epage498en_US
dc.identifier.isiWOS:000179486300021-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHuang, GJ=7403424881en_US
dc.identifier.scopusauthoridZhang, ZQ=8606786700en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US

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