File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: cSox3 expression and neurogenesis in the epibranchial placodes

TitlecSox3 expression and neurogenesis in the epibranchial placodes
Authors
Issue Date2001
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbio
Citation
Developmental Biology, 2001, v. 237 n. 2, p. 258-269 How to Cite?
AbstractEpibranchial placodes are local thickenings of the surface ectoderm, which give rise to sensory neurons of the distal cranial ganglia. The development of these placodes has remained unclear due to the lack of any definitive marker for these structures. We show here that the chick transcription factor, cSox3, is expressed in four lateral patches at the rostral edge of the epibranchial arches and that these mark the epibranchial placodes. These patches of cSox3 expression arise by gradual thinning from broader areas of cSox3 expression with concomitant loss of cSox3 in nonplacodal regions. Cells leaving the epithelial placodes as they initiate neurogenesis, lose cSox3 expression and sequentially express Ngn1, NeuroD, NeuroM, and Phox2a, but do not express Ngn2. This is in contrast to studies in the mouse where it is Ngn2, rather than Ngn1, that is predominantly expressed in epibranchial-derived neuroblasts. Overexpression of cSox3 interferes with normal neuroblast migration and results in changes in ectodermal morphology. Thus, cSox3 provides a useful tool for the study of placode formation, and loss of cSox3 expression appears to be a necessary event in normal neurogenesis from the epibranchial placodes. © 2001 Academic Press.
Persistent Identifierhttp://hdl.handle.net/10722/147467
ISSN
2015 Impact Factor: 3.155
2015 SCImago Journal Rankings: 2.554
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAbuElmagd, Men_US
dc.contributor.authorIshii, Yen_US
dc.contributor.authorCheung, Men_US
dc.contributor.authorRex, Men_US
dc.contributor.authorLe Rouëdec, Den_US
dc.contributor.authorScotting, PJen_US
dc.date.accessioned2012-05-29T06:03:55Z-
dc.date.available2012-05-29T06:03:55Z-
dc.date.issued2001en_US
dc.identifier.citationDevelopmental Biology, 2001, v. 237 n. 2, p. 258-269en_US
dc.identifier.issn0012-1606en_US
dc.identifier.urihttp://hdl.handle.net/10722/147467-
dc.description.abstractEpibranchial placodes are local thickenings of the surface ectoderm, which give rise to sensory neurons of the distal cranial ganglia. The development of these placodes has remained unclear due to the lack of any definitive marker for these structures. We show here that the chick transcription factor, cSox3, is expressed in four lateral patches at the rostral edge of the epibranchial arches and that these mark the epibranchial placodes. These patches of cSox3 expression arise by gradual thinning from broader areas of cSox3 expression with concomitant loss of cSox3 in nonplacodal regions. Cells leaving the epithelial placodes as they initiate neurogenesis, lose cSox3 expression and sequentially express Ngn1, NeuroD, NeuroM, and Phox2a, but do not express Ngn2. This is in contrast to studies in the mouse where it is Ngn2, rather than Ngn1, that is predominantly expressed in epibranchial-derived neuroblasts. Overexpression of cSox3 interferes with normal neuroblast migration and results in changes in ectodermal morphology. Thus, cSox3 provides a useful tool for the study of placode formation, and loss of cSox3 expression appears to be a necessary event in normal neurogenesis from the epibranchial placodes. © 2001 Academic Press.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ydbioen_US
dc.relation.ispartofDevelopmental Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAvian Proteinsen_US
dc.subject.meshBasic Helix-Loop-Helix Transcription Factorsen_US
dc.subject.meshCell Movementen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshDna-Binding Proteins - Biosynthesisen_US
dc.subject.meshEctoderm - Metabolismen_US
dc.subject.meshElectroporationen_US
dc.subject.meshGanglia - Embryologyen_US
dc.subject.meshHigh Mobility Group Proteins - Biosynthesisen_US
dc.subject.meshHomeodomain Proteins - Biosynthesisen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshNerve Tissue Proteins - Biosynthesisen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshNeuropeptides - Biosynthesisen_US
dc.subject.meshSoxb1 Transcription Factorsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTranscription Factors - Biosynthesis - Metabolismen_US
dc.titlecSox3 expression and neurogenesis in the epibranchial placodesen_US
dc.typeArticleen_US
dc.identifier.emailCheung, M:mcheung9@hkucc.hku.hken_US
dc.identifier.authorityCheung, M=rp00245en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/dbio.2001.0378en_US
dc.identifier.pmid11543612-
dc.identifier.scopuseid_2-s2.0-0035884324en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035884324&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume237en_US
dc.identifier.issue2en_US
dc.identifier.spage258en_US
dc.identifier.epage269en_US
dc.identifier.isiWOS:000171209000002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridAbuElmagd, M=6507443075en_US
dc.identifier.scopusauthoridIshii, Y=35401112100en_US
dc.identifier.scopusauthoridCheung, M=7201897461en_US
dc.identifier.scopusauthoridRex, M=7005595101en_US
dc.identifier.scopusauthoridLe Rouëdec, D=23035402400en_US
dc.identifier.scopusauthoridScotting, PJ=7003610298en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats