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Article: Chick Sox10, a transcription factor expressed in both early neural crest cells and central nervous system

TitleChick Sox10, a transcription factor expressed in both early neural crest cells and central nervous system
Authors
Issue Date2000
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/inca/publications/store/5/0/6/0/5/1/
Citation
Developmental Brain Research, 2000, v. 121 n. 2, p. 233-241 How to Cite?
AbstractHuman SOX10 and mouse Sox10 have been cloned and shown to be expressed in the neural crest derivatives that contribute to formation of the peripheral nervous system during embryogenesis. Mutations in Sox10 have been identified as a cause of the Dominant megacolon mouse and Waardenburg-Shah syndrome in human, both of which include defects in the enteric nervous system and pigmentation (and in the latter, sometimes hearing). We have cloned a chick Sox10 ortholog (cSox10) in order to study its role in neural crest cell development. This cDNA reveals a 1383 bp open reading frame encoding 461 amino acids which is highly conserved with human SOX10 and mouse Sox10. In situ hybridization showed cSox10 is expressed in migrating neural crest cells just after the zinc finger transcription factor Slug, but is lost as cells undergo neuronal differentiation in ganglia of the peripheral nervous system. In addition, cSox10 is expressed in the developing otic vesicle, the developing central nervous system and pineal gland. Theme: Development and regeneration. Topic: Developmental genetics. Copyright (C) 2000 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/147457
ISSN
2007 Impact Factor: 1.783
2008 SCImago Journal Rankings: 1.249
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheng, YCen_US
dc.contributor.authorCheung, Men_US
dc.contributor.authorAbuElmagd, MMen_US
dc.contributor.authorOrme, Aen_US
dc.contributor.authorScotting, PJen_US
dc.date.accessioned2012-05-29T06:03:51Z-
dc.date.available2012-05-29T06:03:51Z-
dc.date.issued2000en_US
dc.identifier.citationDevelopmental Brain Research, 2000, v. 121 n. 2, p. 233-241en_US
dc.identifier.issn0165-3806en_US
dc.identifier.urihttp://hdl.handle.net/10722/147457-
dc.description.abstractHuman SOX10 and mouse Sox10 have been cloned and shown to be expressed in the neural crest derivatives that contribute to formation of the peripheral nervous system during embryogenesis. Mutations in Sox10 have been identified as a cause of the Dominant megacolon mouse and Waardenburg-Shah syndrome in human, both of which include defects in the enteric nervous system and pigmentation (and in the latter, sometimes hearing). We have cloned a chick Sox10 ortholog (cSox10) in order to study its role in neural crest cell development. This cDNA reveals a 1383 bp open reading frame encoding 461 amino acids which is highly conserved with human SOX10 and mouse Sox10. In situ hybridization showed cSox10 is expressed in migrating neural crest cells just after the zinc finger transcription factor Slug, but is lost as cells undergo neuronal differentiation in ganglia of the peripheral nervous system. In addition, cSox10 is expressed in the developing otic vesicle, the developing central nervous system and pineal gland. Theme: Development and regeneration. Topic: Developmental genetics. Copyright (C) 2000 Elsevier Science B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/inca/publications/store/5/0/6/0/5/1/en_US
dc.relation.ispartofDevelopmental Brain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAuditory Pathways - Chemistry - Embryology - Physiologyen_US
dc.subject.meshCentral Nervous System - Chemistry - Embryology - Physiologyen_US
dc.subject.meshChick Embryoen_US
dc.subject.meshChickensen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshGene Expression Regulation, Developmental - Physiologyen_US
dc.subject.meshHigh Mobility Group Proteins - Geneticsen_US
dc.subject.meshHirschsprung Disease - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridizationen_US
dc.subject.meshMiceen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeural Crest - Chemistry - Embryology - Physiologyen_US
dc.subject.meshNeuroglia - Chemistry - Physiologyen_US
dc.subject.meshNeurons - Chemistry - Physiologyen_US
dc.subject.meshPineal Gland - Chemistry - Embryology - Physiologyen_US
dc.subject.meshRna, Messenger - Analysisen_US
dc.subject.meshSoxe Transcription Factorsen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.subject.meshWaardenburg's Syndrome - Geneticsen_US
dc.titleChick Sox10, a transcription factor expressed in both early neural crest cells and central nervous systemen_US
dc.typeArticleen_US
dc.identifier.emailCheung, M:mcheung9@hkucc.hku.hken_US
dc.identifier.authorityCheung, M=rp00245en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0165-3806(00)00049-3en_US
dc.identifier.pmid10876038en_US
dc.identifier.scopuseid_2-s2.0-0034733795en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034733795&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume121en_US
dc.identifier.issue2en_US
dc.identifier.spage233en_US
dc.identifier.epage241en_US
dc.identifier.isiWOS:000088055800013-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridCheng, YC=7404913989en_US
dc.identifier.scopusauthoridCheung, M=7201897461en_US
dc.identifier.scopusauthoridAbuElmagd, MM=6507443075en_US
dc.identifier.scopusauthoridOrme, A=7003463196en_US
dc.identifier.scopusauthoridScotting, PJ=7003610298en_US

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