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Article: Role of adapter function in oncoprotein-mediated activation of NF-κB: Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ

TitleRole of adapter function in oncoprotein-mediated activation of NF-κB: Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γ
Authors
Issue Date1999
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal of Biological Chemistry, 1999, v. 274 n. 25, p. 17402-17405 How to Cite?
AbstractMechanisms by which the human T-cell leukemia virus type I Tax oncoprotein activates NF-κB remain incompletely understood. Although others have described an interaction between Tax and a holo-IκB kinase (IKK) complex, the exact details of protein-protein contact are not fully defined. Here we show that Tax binds to neither IKK-α nor IKK-β but instead complexes directly with IKK-γ, a newly characterized component of the IKK complex. This direct interaction with IKK-γ correlates with Tax-induced IκB-α phosphorylation and NF-κB activation. Thus, our findings establish IKKγ as a key molecule for adapting an oncoprotein-specific signaling to IKK-α and IKK-β.
Persistent Identifierhttp://hdl.handle.net/10722/147443
ISSN
2015 Impact Factor: 4.258
2015 SCImago Journal Rankings: 3.151
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, DYen_US
dc.contributor.authorGiordano, Ven_US
dc.contributor.authorKibler, KVen_US
dc.contributor.authorNakano, Hen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-05-29T06:03:45Z-
dc.date.available2012-05-29T06:03:45Z-
dc.date.issued1999en_US
dc.identifier.citationJournal of Biological Chemistry, 1999, v. 274 n. 25, p. 17402-17405en_US
dc.identifier.issn0021-9258en_US
dc.identifier.urihttp://hdl.handle.net/10722/147443-
dc.description.abstractMechanisms by which the human T-cell leukemia virus type I Tax oncoprotein activates NF-κB remain incompletely understood. Although others have described an interaction between Tax and a holo-IκB kinase (IKK) complex, the exact details of protein-protein contact are not fully defined. Here we show that Tax binds to neither IKK-α nor IKK-β but instead complexes directly with IKK-γ, a newly characterized component of the IKK complex. This direct interaction with IKK-γ correlates with Tax-induced IκB-α phosphorylation and NF-κB activation. Thus, our findings establish IKKγ as a key molecule for adapting an oncoprotein-specific signaling to IKK-α and IKK-β.en_US
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_US
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.subject.meshDna-Binding Proteins - Metabolismen_US
dc.subject.meshGene Products, Tax - Metabolismen_US
dc.subject.meshHela Cellsen_US
dc.subject.meshHumansen_US
dc.subject.meshI-Kappa B Kinaseen_US
dc.subject.meshI-Kappa B Proteinsen_US
dc.subject.meshNf-Kappa B - Metabolismen_US
dc.subject.meshOncogene Proteins - Metabolismen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshProtein-Serine-Threonine Kinases - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshTranscriptional Activationen_US
dc.subject.meshTransfectionen_US
dc.titleRole of adapter function in oncoprotein-mediated activation of NF-κB: Human T-cell leukemia virus type I Tax interacts directly with IκB kinase γen_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1074/jbc.274.25.17402en_US
dc.identifier.pmid10364167-
dc.identifier.scopuseid_2-s2.0-0033580931en_US
dc.identifier.hkuros46170-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033580931&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume274en_US
dc.identifier.issue25en_US
dc.identifier.spage17402en_US
dc.identifier.epage17405en_US
dc.identifier.isiWOS:000080974300003-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridGiordano, V=36795391000en_US
dc.identifier.scopusauthoridKibler, KV=6701686388en_US
dc.identifier.scopusauthoridNakano, H=7404450326en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

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