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Article: Isolation of full-length cDNA and chromosomal localization of human NF- κB modulator NEMO to Xq28

TitleIsolation of full-length cDNA and chromosomal localization of human NF- κB modulator NEMO to Xq28
Authors
Issue Date1999
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1021-7770
Citation
Journal of Biomedical Science, 1999, v. 6 n. 2, p. 115-120 How to Cite?
AbstractNEMO is an essential component of the IκB kinase complex. Others have shown that expression of mouse NEMO can complement the lack of responsiveness to NF-κB stimuli in two NEMO-deficient cell lines. Here we report the isolation of a full-length human NEMO cDNA. Virtual translation of human NEMO cDNA predicts a 48-kD coiled-coil protein which shares 87.9% identity and 90.5% similarity with the mouse homolog. By sequence alignment, we mapped the human NEMO gene to chromosome Xq28. We note that the NEMO and the G6PD (glucose-6-phosphate dehydrogenase) loci are arranged in a head-to-head orientation separated by no more than 800 bp. This map location is further supported by the sequence of an alternatively spliced variant of human NEMO mRNA. Thus, human NEMO is an X-linked gene closely adjacent to the G6PD locus.
Persistent Identifierhttp://hdl.handle.net/10722/147438
ISSN
2015 Impact Factor: 2.935
2015 SCImago Journal Rankings: 1.280
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, DYen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-05-29T06:03:43Z-
dc.date.available2012-05-29T06:03:43Z-
dc.date.issued1999en_US
dc.identifier.citationJournal of Biomedical Science, 1999, v. 6 n. 2, p. 115-120en_US
dc.identifier.issn1021-7770en_US
dc.identifier.urihttp://hdl.handle.net/10722/147438-
dc.description.abstractNEMO is an essential component of the IκB kinase complex. Others have shown that expression of mouse NEMO can complement the lack of responsiveness to NF-κB stimuli in two NEMO-deficient cell lines. Here we report the isolation of a full-length human NEMO cDNA. Virtual translation of human NEMO cDNA predicts a 48-kD coiled-coil protein which shares 87.9% identity and 90.5% similarity with the mouse homolog. By sequence alignment, we mapped the human NEMO gene to chromosome Xq28. We note that the NEMO and the G6PD (glucose-6-phosphate dehydrogenase) loci are arranged in a head-to-head orientation separated by no more than 800 bp. This map location is further supported by the sequence of an alternatively spliced variant of human NEMO mRNA. Thus, human NEMO is an X-linked gene closely adjacent to the G6PD locus.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1021-7770en_US
dc.relation.ispartofJournal of Biomedical Scienceen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshDna, Complementaryen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.subject.meshSequence Homology, Nucleic Aciden_US
dc.subject.meshTranscription Factors - Geneticsen_US
dc.subject.meshX Chromosomeen_US
dc.titleIsolation of full-length cDNA and chromosomal localization of human NF- κB modulator NEMO to Xq28en_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02256442-
dc.identifier.doi10.1159/000025378-
dc.identifier.pmid10087442-
dc.identifier.scopuseid_2-s2.0-0033051635en_US
dc.identifier.hkuros46162-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033051635&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume6en_US
dc.identifier.issue2en_US
dc.identifier.spage115en_US
dc.identifier.epage120en_US
dc.identifier.isiWOS:000079320500006-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

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