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Article: Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

TitleHuman T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1
Authors
Issue Date1998
PublisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cell
Citation
Cell, 1998, v. 93 n. 1, p. 81-91 How to Cite?
AbstractIn searching for cellular targets of the HTLV-I oncoprotein Tax, we identified TXBP181, which we characterized as the human homolog of yeast mitotic checkpoint MAD1 protein. Evidence supporting TXBP181 as HsMAD1 includes sequence conservation with yeast MAD1, hyperphosphorylation during S/G2/M phases and upon treatment of cells with nocodazole, and binding to HsMAD2. HsMAD1 functions as a homodimer. It localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telophase. Expression of either Tax or a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consistent with a loss of HsMAD1 function. We propose a model of viral transformation in which Tax targets TXBP181, thereby abrogating a mitotic checkpoint.
Persistent Identifierhttp://hdl.handle.net/10722/147433
ISSN
2015 Impact Factor: 28.71
2015 SCImago Journal Rankings: 28.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, DYen_US
dc.contributor.authorSpencer, Fen_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-05-29T06:03:41Z-
dc.date.available2012-05-29T06:03:41Z-
dc.date.issued1998en_US
dc.identifier.citationCell, 1998, v. 93 n. 1, p. 81-91en_US
dc.identifier.issn0092-8674en_US
dc.identifier.urihttp://hdl.handle.net/10722/147433-
dc.description.abstractIn searching for cellular targets of the HTLV-I oncoprotein Tax, we identified TXBP181, which we characterized as the human homolog of yeast mitotic checkpoint MAD1 protein. Evidence supporting TXBP181 as HsMAD1 includes sequence conservation with yeast MAD1, hyperphosphorylation during S/G2/M phases and upon treatment of cells with nocodazole, and binding to HsMAD2. HsMAD1 functions as a homodimer. It localizes to the centrosome during metaphase and to the spindle midzone and the midbody during anaphase and telophase. Expression of either Tax or a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consistent with a loss of HsMAD1 function. We propose a model of viral transformation in which Tax targets TXBP181, thereby abrogating a mitotic checkpoint.en_US
dc.languageengen_US
dc.publisherCell Press. The Journal's web site is located at http://www.elsevier.com/locate/cellen_US
dc.relation.ispartofCellen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshCarrier Proteins - Chemistry - Metabolismen_US
dc.subject.meshCell Cycle - Physiologyen_US
dc.subject.meshCell Cycle Proteinsen_US
dc.subject.meshConserved Sequenceen_US
dc.subject.meshGene Products, Tax - Chemistry - Metabolismen_US
dc.subject.meshHela Cellsen_US
dc.subject.meshHuman T-Lymphotropic Virus 1 - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMammalsen_US
dc.subject.meshMitosisen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNocodazole - Pharmacologyen_US
dc.subject.meshNuclear Proteins - Chemistry - Metabolismen_US
dc.subject.meshPhosphoproteins - Chemistry - Metabolismen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshRecombinant Fusion Proteins - Chemistry - Metabolismen_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshSaccharomyces Cerevisiae - Metabolismen_US
dc.subject.meshSaccharomyces Cerevisiae Proteinsen_US
dc.subject.meshSequence Alignmenten_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.titleHuman T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1en_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0092-8674(00)81148-4en_US
dc.identifier.pmid9546394-
dc.identifier.scopuseid_2-s2.0-0032478547en_US
dc.identifier.hkuros46118-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032478547&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume93en_US
dc.identifier.issue1en_US
dc.identifier.spage81en_US
dc.identifier.epage91en_US
dc.identifier.isiWOS:000072910800012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridSpencer, F=7102173759en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

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