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Article: Prevalence and genotype of hepatitis G virus in Chinese professional blood donors and hepatitis patients

TitlePrevalence and genotype of hepatitis G virus in Chinese professional blood donors and hepatitis patients
Authors
Issue Date1997
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
Journal Of Infectious Diseases, 1997, v. 175 n. 5, p. 1229-1233 How to Cite?
AbstractPrevalence of hepatitis G virus (HGV) was determined in a cohort of Chinese blood donors and hepatitis patients by the detection of viral RNA via reverse transcription-polymerase chain reaction. While HGV RNA was detected in only 1 of 150 healthy volunteers, the detection rate among professional blood donors was surprisingly high (21/265, 7.9%), and plasmapheresis was identified as a significant risk factor in this population. It was also shown that an elevated serum alanine aminotransferase level is not a reliable marker for HGV infection. Prevalences of HGV in patients with hepatitis C, with non-A-E hepatitis, and with hepatocellular carcinoma were relatively low (8.2%, 16.7%, and 6.1%, respectively). Striking sequence homology (>90%) shared by 5 HGV cDNA clones implicated that they belonged to the same genotype. Phylogenetic analysis of a 446-bp NS3 cDNA confirmed that this genotype was closely related to the prototype viruses.
Persistent Identifierhttp://hdl.handle.net/10722/147416
ISSN
2015 Impact Factor: 6.344
2015 SCImago Journal Rankings: 4.000
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, HLen_US
dc.contributor.authorJin, DYen_US
dc.date.accessioned2012-05-29T06:03:34Z-
dc.date.available2012-05-29T06:03:34Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of Infectious Diseases, 1997, v. 175 n. 5, p. 1229-1233en_US
dc.identifier.issn0022-1899en_US
dc.identifier.urihttp://hdl.handle.net/10722/147416-
dc.description.abstractPrevalence of hepatitis G virus (HGV) was determined in a cohort of Chinese blood donors and hepatitis patients by the detection of viral RNA via reverse transcription-polymerase chain reaction. While HGV RNA was detected in only 1 of 150 healthy volunteers, the detection rate among professional blood donors was surprisingly high (21/265, 7.9%), and plasmapheresis was identified as a significant risk factor in this population. It was also shown that an elevated serum alanine aminotransferase level is not a reliable marker for HGV infection. Prevalences of HGV in patients with hepatitis C, with non-A-E hepatitis, and with hepatocellular carcinoma were relatively low (8.2%, 16.7%, and 6.1%, respectively). Striking sequence homology (>90%) shared by 5 HGV cDNA clones implicated that they belonged to the same genotype. Phylogenetic analysis of a 446-bp NS3 cDNA confirmed that this genotype was closely related to the prototype viruses.en_US
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.orgen_US
dc.relation.ispartofJournal of Infectious Diseasesen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBlood Donorsen_US
dc.subject.meshCarcinoma, Hepatocellular - Virologyen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDna Primersen_US
dc.subject.meshFlaviviridae - Genetics - Isolation & Purificationen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHepatitis, Viral, Human - Classification - Epidemiology - Virologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Neoplasms - Virologyen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRna, Viral - Blooden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSequence Homology, Amino Aciden_US
dc.titlePrevalence and genotype of hepatitis G virus in Chinese professional blood donors and hepatitis patientsen_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid9129092-
dc.identifier.scopuseid_2-s2.0-0030898788en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030898788&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume175en_US
dc.identifier.issue5en_US
dc.identifier.spage1229en_US
dc.identifier.epage1233en_US
dc.identifier.isiWOS:A1997WW72600030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, HL=8081373900en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US

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