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Article: Divergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization

TitleDivergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalization
Authors
KeywordsHtlv
Int-6
Tax
Transformation
Issue Date1997
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1021-7770
Citation
Journal Of Biomedical Science, 1997, v. 4 n. 5, p. 229-234 How to Cite?
AbstractProtein-protein interactions define many important molecular and cellular processes in prokaryotic and eukaryotic biology. In trying to delineate the contact between two proteins, the yeast two-hybrid assay has emerged as a powerful technique. Complementing the yeast two-hybrid assay are in vitro techniques (e.g. GST-fusion-protein chromatography) that can also yield information on protein-protein associations. However, unambiguous functional significance to these interactions is best supported through a finding of colocalization of two proteins inside cells. In instances where two proteins interact in vitro but have divergent localizations within cells one needs to reconsider the biological importance of the former finding. Here, we present evidence for different subcellular locations of HTLV-I Tax and the Int-6 protein. We suggest a reexploration of the functional significance between Tax and Int-6 in cellular transformation.
Persistent Identifierhttp://hdl.handle.net/10722/147415
ISSN
2015 Impact Factor: 2.935
2015 SCImago Journal Rankings: 1.280
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNeuveut, Cen_US
dc.contributor.authorJin, DYen_US
dc.contributor.authorSemmes, OJen_US
dc.contributor.authorDiella, Fen_US
dc.contributor.authorCallahan, Ren_US
dc.contributor.authorJeang, KTen_US
dc.date.accessioned2012-05-29T06:03:33Z-
dc.date.available2012-05-29T06:03:33Z-
dc.date.issued1997en_US
dc.identifier.citationJournal Of Biomedical Science, 1997, v. 4 n. 5, p. 229-234en_US
dc.identifier.issn1021-7770en_US
dc.identifier.urihttp://hdl.handle.net/10722/147415-
dc.description.abstractProtein-protein interactions define many important molecular and cellular processes in prokaryotic and eukaryotic biology. In trying to delineate the contact between two proteins, the yeast two-hybrid assay has emerged as a powerful technique. Complementing the yeast two-hybrid assay are in vitro techniques (e.g. GST-fusion-protein chromatography) that can also yield information on protein-protein associations. However, unambiguous functional significance to these interactions is best supported through a finding of colocalization of two proteins inside cells. In instances where two proteins interact in vitro but have divergent localizations within cells one needs to reconsider the biological importance of the former finding. Here, we present evidence for different subcellular locations of HTLV-I Tax and the Int-6 protein. We suggest a reexploration of the functional significance between Tax and Int-6 in cellular transformation.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1021-7770en_US
dc.relation.ispartofJournal of Biomedical Scienceen_US
dc.subjectHtlven_US
dc.subjectInt-6en_US
dc.subjectTaxen_US
dc.subjectTransformationen_US
dc.titleDivergent subcellular locations of HTLV-I tax and Int-6: A contrast between in vitro protein-protein binding and intracellular protein colocalizationen_US
dc.typeArticleen_US
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_US
dc.identifier.authorityJin, DY=rp00452en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/BF02253422en_US
dc.identifier.scopuseid_2-s2.0-0030844154en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0030844154&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume4en_US
dc.identifier.issue5en_US
dc.identifier.spage229en_US
dc.identifier.epage234en_US
dc.identifier.isiWOS:A1997YE38200004-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridNeuveut, C=6602879302en_US
dc.identifier.scopusauthoridJin, DY=7201973614en_US
dc.identifier.scopusauthoridSemmes, OJ=7003428900en_US
dc.identifier.scopusauthoridDiella, F=6603579100en_US
dc.identifier.scopusauthoridCallahan, R=7102667344en_US
dc.identifier.scopusauthoridJeang, KT=7004824803en_US

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